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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Maria Kowalczuk
Welcome to BMC Bioinformatics published by BioMed Central
BMC Bioinformatics is an open access journal publishing original peer-reviewed research articles in all aspects of computational methods used in the analysis and annotation of sequences and structures, as well as all other areas of computational biology.
BMC Bioinformatics (ISSN 1471-2105) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus, EMBASE, Thomson Reuters (ISI) and Google Scholar.
BMC Bioinformatics 2008, 9 :353
The MisPred tool improves gene predictions within public databases by using five distinct approaches to detect incomplete or incorrect sequences, such as missing signal peptides or problems with domain integrity.
BMC Bioinformatics 2008, 9 :292
The effect of genetic pathways on disease outcome can be estimated by combining both parametric and non-parametric modeling using kernel machines, a framework that includes nonlinear effects and interactions between genes within a single pathway.
BMC Bioinformatics 2008, 9 :286
By comparing an organism's chromosomes to those of closely related species using a segmentation algorithm, breakpoints can be precisely delimited and their internal structure described, providing insights into the mechanisms and evolutionary properties of chromosomal rearrangements.
BMC Bioinformatics 2008, 9 :284
Comparison of the most commonly used statistical methods for assessing differential gene expression from Affymetrix microarrays on a high-quality dataset shows that PDNN is the best performer, clearly superior to the standard Affymetrix MAS5.0 method.
BMC Bioinformatics 2008, 9 :266
Metabolic flux ratios can be quickly derived using a new framework that automatically analyses 13C tracer measurements by using metabolic network models, removing the need for tedious manual analysis.
Volume 9 Suppl 9
Proceedings
Oklahoma City, OK, USA. 23 Volume 9 Suppl 8
Proceedings
Evry, France. 25 Volume 9 Suppl 7
Meeting abstracts
Cadiz, KY, USA. 28
more info ]
Software
GenomeMatcher: A graphical user interface for DNA sequence comparison Yoshiyuki Ohtsubo, Wakako Ikeda-Ohtsubo, Yuji Nagata, Masataka Tsuda BMC Bioinformatics 2008, 9 :376 (16 [Abstract ] [Provisional PDF ]
Research article
Critical assessment of alignment procedures for LC-MS proteomics and metabolomics measurements Eva Lange, Ralf Tautenhahn, Steffen Neumann, Clemens Groepl BMC Bioinformatics 2008, 9 :375 (15 [Abstract ] [Provisional PDF ]
Methodology article
Large-scale identification of polymorphic microsatellites
using an in silico approach
Jifeng Tang, Samantha J Baldwin, Jeanne ME Jacobs, C GERARD van der Linden, Roeland E Voorrips, Jack AM Leunissen, Herman van Eck, Ben Vosman BMC Bioinformatics 2008, 9 :374 (15 [Abstract ] [Provisional PDF ]
Research article
Increasing the efficiency of bacterial transcription simulations: when to exclude the genome without loss of accuracy Marco A. J. Iafolla, Guang Qiang Dong, David R McMillen BMC Bioinformatics 2008, 9 :373 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast Uri Keich, Hong Gao, Jeffrey S Garretson, Anand Bhaskar, Ivan Liachko, Justin Donato, Bik K Tye BMC Bioinformatics 2008, 9 :372 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
Kismeth: Analyzer of plant methylation states through bisulfite sequencing Eyal Gruntman, Yijun Qi, Richard KEITH Slotkin, Ted Roeder, Robert A Martienssen, Ravi Sachidanandam BMC Bioinformatics 2008, 9 :371 (11 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Methodology article
Mixture models for analysis of melting temperature data. Christoffer Nellaker, Fredrik Uhrzander, Joanna Tyrcha, Hakan Karlsson BMC Bioinformatics 2008, 9 :370 (11 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Automatic detection of exonic splicing enhancers (ESEs) using SVMs Britta Mersch, Alexander Gepperth, Sandor Suhai, Agnes Hotz-Wagenblatt BMC Bioinformatics 2008, 9 :369 (10 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
LOMA: A fast method to generate efficient tagged-random primers despite amplification bias of random PCR on pathogens Wah Heng Lee, Christopher W Wong, Wan Yee Leong, Lance D Miller, Wing Kin Sung BMC Bioinformatics 2008, 9 :368 (10 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
IgTM: an algorithm to predict transmembrane domains and topology in proteins Piedachu Peris, Damian Lopez, Marcelino Campos BMC Bioinformatics 2008, 9 :367 (10 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
The use of Gene Ontology terms for predicting highly-connected 'hub' nodes in protein-protein interaction networks. Michael Hsing, Kendall Grant Byler, Artem Cherkasov BMC Systems Biology 2008, 2 :80 (16 [Abstract ] [Provisional PDF ]
Methodology article
A combination of LongSAGE with Solexa sequencing is well suited to explore the depth and the complexity of transcriptome Lucie Hanriot, Celine Keime, Nadine Gay, Claudine Faure, Carole Dossat, Patrick Wincker, Celine Scote-Blachon, Christelle Peyron, Olivier Gandrillon BMC Genomics 2008, 9 :418 (16 [Abstract ] [Provisional PDF ]
Research
CAIcal: a combined set of tools to assess codon usage adaptation Pere Puigbo, Ignacio G Bravo, Santiago Garcia-Vallve Biology Direct 2008, 3 :38 (16 [Abstract ] [Provisional PDF ]
Method
Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays Johan Staaf, David Lindgren, Johan Vallon-Christersson, Anders Isaksson, Hanna Goransson, Gunnar Juliusson, Richard Rosenquist, Mattias Hoglund, Ake Borg, Markus Ringner Genome Biology 2008, 9 :R136 (16 [Abstract ] [Provisional PDF ]
Research article
In silico analysis and verification of S100 gene expression in gastric cancer Ji Liu, Xue Li, Guang-long Dong, Hong-wei Zhang, Dong-li Chen, Jian-jun Du, Jian-yong Zheng, Ji-peng Li, Wei-zhong Wang BMC Cancer 2008, 8 :261 (16 [Abstract ] [Provisional PDF ]
Research article
A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory. Juan Nogales, Bernhard O. Palsson, Ines Thiele BMC Systems Biology 2008, 2 :79 (16 [Abstract ] [Provisional PDF ]
Research article
A high confidence, manually validated human blood plasma protein reference set Susann Schenk, Gary J Schoenhals, Gustavo DE Souza, Matthias Mann BMC Medical Genomics 2008, 1 :41 (15 [Abstract ] [Provisional PDF ]
Software
BOV - a web-based BLAST output visualization tool Rajesh Gollapudi, Kashi Revanna, Chris Hemmerich, Sarah Schaack, Qunfeng Dong BMC Genomics 2008, 9 :414 (15 [Abstract ] [Provisional PDF ]
Research article
The protein-phosphatome of the human malaria parasite Plasmodium falciparum Jonathan M Wilkes, Christian Doerig BMC Genomics 2008, 9 :412 (15 [Abstract ] [Provisional PDF ]
Research
Modeling synthetic lethality Nolwenn Le Meur, Robert Gentleman Genome Biology 2008, 9 :R135 (12 [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Featured articles
24 February 2008
