Protocol Number: 05-D-0051

Title:

Collection of Dental Plaque and Saliva for Studies of Oral Microbial Colonization

Number:

05-D-0051

Summary:

This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and from adults to infants.

Selected NIH scientists and members of their immediate families, including infants, are eligible for this study. Participants provide a small sample of saliva and a sample of bacteria collected by rubbing a cotton swab over the surfaces of the lower four incisors. Adults collect and submit their own specimens; a dentist collects specimens from children.

Sponsoring Institute:

National Institute of Dental And Craniofacial Research (NIDCR)

Recruitment Detail

Type: No longer recruiting/follow-up only

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Bacteria

Biofilm Formation

Secretory Antibodies

Teeth

Health and Disease

Recruitment Keyword(s):

Teeth

Bacteria

Condition(s):

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Institute of Dental and Craniofacial Research

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Cisar JO, Sandberg AL, Abeygunawardana C, Reddy GP, Bush CA. Lectin recognition of host-like saccharide motifs in streptococcal cell wall polysaccharides. Glycobiology. 1995 Oct;5(7):655-62.

Takahashi Y, Sandberg AL, Ruhl S, Muller J, Cisar JO. A specific cell surface antigen of Streptococcus gordonii is associated with bacterial hemagglutination and adhesion to alpha2-3-linked sialic acid-containing receptors. Infect Immun. 1997 Dec;65(12):5042-51.

Takahashi Y, Ruhl S, Yoon JW, Sandberg AL, Cisar JO. Adhesion of viridans group streptococci to sialic acid-, galactose- and N-acetylgalactosamine-containing receptors. Oral Microbiol Immunol. 2002 Aug;17(4):257-62.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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