Protocol Number: 94-D-0188

Title:

Bone Regeneration Using Bone Marrow Stromal Cells

Number:

94-D-0188

Summary:

This study will evaluate the possible use of bone marrow stromal cells-a type of cell related to bone and fibrous tissue-for jaw bone grafting. When a tooth is lost or removed, there is usually a gradual loss of bony tissue from the jawbone at the site of the missing tooth. This bone loss causes fragility that can extend and contribute to further tooth loss, and can make the use of dental implants less feasible. Stromal cells may become a source of cells for jawbone grafting to strengthen these areas.

Normal volunteers between the ages of 18 and 70 years may be eligible for this study. Participants will fill out a medical history questionnaire, donate a small sample of bone marrow, and undergo a marrow biopsy, if needed. Bone marrow is aspirated from the ridge of the pelvic (hip) bone. For this procedure, the area is anesthetized with an injection of lidocaine, a needle is inserted into the bone and some marrow is sucked out into a syringe attached to the needle. If a biopsy specimen is needed, a special instrument is passed through the same spot as the aspiration and a small piece of bone marrow is taken out. The procedure takes about half an hour.

Sponsoring Institute:

National Institute of Dental And Craniofacial Research (NIDCR)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Males and females 18 years and older.

EXCLUSION CRITERIA:

Subjects may not have metabolic bone diseases, pregnancy or taking drugs affecting skeletal metabolism.

Special Instructions:

Currently Not Provided

Keywords:

Augmentation

Osteogenesis

Stem Cells

Bone Formation

Bone Induction

Recruitment Keyword(s):

None

Condition(s):

Bone Disease

Craniofacial Abnormality

Healthy

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Dental and Craniofacial Research

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Stromal stem cells: marrow-derived osteogenic precursors

Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts

Healing of bone defects by guided tissue regeneration

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 09/20/2008