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Protocol Number:
94-D-0188
- Title:
Bone Regeneration Using Bone Marrow Stromal Cells
- Number:
94-D-0188
- Summary:
This study will evaluate the possible use of bone marrow stromal cells-a type of cell related to bone and fibrous tissue-for jaw bone grafting. When a tooth is lost or removed, there is usually a gradual loss of bony tissue from the jawbone at the site of the missing tooth. This bone loss causes fragility that can extend and contribute to further tooth loss, and can make the use of dental implants less feasible. Stromal cells may become a source of cells for jawbone grafting to strengthen these areas.
Normal volunteers between the ages of 18 and 70 years may be eligible for this study. Participants will fill out a medical history questionnaire, donate a small sample of bone marrow, and undergo a marrow biopsy, if needed. Bone marrow is aspirated from the ridge of the pelvic (hip) bone. For this procedure, the area is anesthetized with an injection of lidocaine, a needle is inserted into the bone and some marrow is sucked out into a syringe attached to the needle. If a biopsy specimen is needed, a special instrument is passed through the same spot as the aspiration and a small piece of bone marrow is taken out. The procedure takes about half an hour.
- Sponsoring Institute:
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National Institute of Dental And Craniofacial Research (NIDCR)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Males and females 18 years and older.
EXCLUSION CRITERIA:
Subjects may not have metabolic bone diseases, pregnancy or taking drugs affecting skeletal metabolism.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Augmentation
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Osteogenesis
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Stem Cells
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Bone Formation
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Bone Induction
- Recruitment Keyword(s):
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None
- Condition(s):
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Bone Disease
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Craniofacial Abnormality
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Healthy
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Dental and Craniofacial Research
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Stromal stem cells: marrow-derived osteogenic precursors
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Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts
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Healing of bone defects by guided tissue regeneration
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/20/2008
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