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Protocol Number:
08-N-0027
- Title:
HHV6B in Epilepsy Imaging and CSF Studies
- Number:
08-N-0027
- Summary:
This study will look for evidence that a virus called HHV-6B may be related to seizures and to a form of brain injury called mesial temporal sclerosis that is associated with seizures. The study will use new, more sensitive brain scans to try to detect brain regions that might be affected by the virus and will examine cerebrospinal fluid (CSF, the fluid that bathes the brain and spinal cord) for evidence of the virus as well.
Healthy volunteers and people with seizures uncontrolled by anti-epileptic drugs who are between 18 and 45 years of age may be eligible for this study. Candidates are screened with a physical examination and laboratory tests.
Participants undergo the following procedures:
-PET scan. This test uses a radioactive chemical called 18FDG, which is detected by the PET scanner to obtain images of the brain. The subject lies on a table with his or her head positioned in the scanner. A swimming cap with a small light reflector is placed on the head to monitor the position of the head during the scan. A catheter (plastic tube) is inserted into an artery at the wrist or elbow crease of the arm for obtaining blood samples during the scan, and a second catheter is placed in a vein in the other arm for injecting the 18FDG. The scan takes up to 2 hours. A second scan may be done over an additional 15 minutes.
-MRI. This test uses a strong magnetic field and radio waves to obtain images of the brain. The subject lies on a table that can slide in and out of a metal cylinder surrounded by a magnetic field. Most scans last between 45 and 90 minutes.
-Lumbar puncture. The subject sits upright or lies on a table with the knees curled to the chest for this procedure. A local anesthetic is injected to numb the skin and a needle is inserted in the space between the bones in the lower back where the CSF circulates below the spinal cord. A small amount of fluid is collected through the needle.
-Blood tests. About 4 tablespoons of blood are drawn for viral tests.
- Sponsoring Institute:
-
National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
45 patients with localization-related epilepsy age 18-45
Patients referred to the NIH by community physicians or by self-referral will be evaluated for participation under screening protocol 01N-0139, including a 3T MRI at NIH if this has not already been performed.
45 Healthy volunteers will be recruited from the community.
EXCLUSION CRITERIA:
A positive urine pregnancy test
Evidence for progressive neurological disease
Presence of a lesion on 3T MRI that high resolution imaging is unlikely to elucidate in greater detail (for patients)
Inability or unwillingness to undergo LP, MRI and/or PET
Systemic disease or chronic ingestion of substances that might affect cerebral glucose metabolism
Chronic administration of drugs affecting blood clotting.
Subjects over 45
- Special Instructions:
Currently Not Provided
- Keywords:
-
18-F-Fluoro-2-Deoxy-D-Glucose (FDG)
-
Magnetic Resonance
-
Epilepsy
-
HHV-6B
- Recruitment Keyword(s):
-
Epilepsy
-
Healthy Volunteer
-
HV
- Condition(s):
-
Epilepsy
-
HHV6B Infection
- Investigational Drug(s):
-
Fluorodeoxyglucose
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Neurological Disorders and Stroke
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Baker GA, Nashef L, van Hout BA. Current issues in the management of epilepsy: the impact of frequent seizures on cost of illness, quality of life, and mortality. Epilepsia. 1997;38 Suppl 1:S1-8. Review.
-
Begley CE, Famulari M, Annegers JF, Lairson DR, Reynolds TF, Coan S, Dubinsky S, Newmark ME, Leibson C, So EL, Rocca WA. The cost of epilepsy in the United States: an estimate from population-based clinical and survey data. Epilepsia. 2000 Mar;41(3):342-51.
-
Berg AT, Vickrey BG, Testa FM, Levy SR, Shinnar S, DiMario F, Smith S. How long does it take for epilepsy to become intractable? A prospective investigation. Ann Neurol. 2006 Jul;60(1):73-9.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/20/2008
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