Protocol Number: 08-DK-0098
Members of families in which two or more immediate blood relatives have had gastrointestinal carcinoid tumors may be eligible for this study. Unaffected spouses of family members diagnosed with carcinoid cancer are also requested to participate. Participants undergo a medical evaluation every 2 years during a 3- to 5-day hospital stay at the NIH Clinical Center. (Unaffected spouses undergo only the initial evaluation.) All participants have a personal and family medical history obtained and undergo a physical examination, blood and urine tests and genetic counseling. People who already have a carcinoid tumor or are at risk of developing a carcinoid tumor have the following additional procedures to determine the presence of carcinoid tumor and its location or spread to other areas of the body: Children between 5 and 10 years of age: Medical history, physical examination and blood tests. Children between 10 and 18 years of age: Medical history and physical examination. Additional tests for children in this group with symptoms or signs of carcinoid tumor may include video capsule endoscopy, computed tomography (CT) scans, magnetic resonance imaging (MRI) and somatostatin receptor scintigraphy (Octreoscan). Adults: -Upper endoscopy: Examination of the esophagus, stomach and upper small intestine using a flexible tube (endoscope) passed from the throat through the upper gastrointestinal tract. -Colonoscopy: Examination of the colon using an endoscope inserted through the anus. -Capsule endoscopy: Visualization of the small intestine by ingesting a disposable, vitamin-pill sized video capsule that has its own camera and light source. -CT of the chest and abdomen: X-ray examination of the chest and abdominal organs. -MRI of the abdomen: Examination of the abdominal organs using a magnetic field and radio waves. -Octreoscan: Nuclear imaging scan performed over 1 to 3 days to detect the primary site of the tumor and any places it has spread. -Positron emission tomography (PET): Nuclear imaging scan to look at tumor activity.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/20/2008
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