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Protocol Number:
99-H-0037
- Title:
Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. A Pre-Clinical Study of Selective Depletion of Donor Lymphocytes to Prevent Acute Graft-Versus-Host Disease
- Number:
99-H-0037
- Summary:
Blood contains different kinds of cells, white blood cells, red blood cells, and platelets. In order to treat certain diseases, specific cell types can be removed from blood and transplanted into patients. The process of removing white blood cells for the treatment of leukemia is called apheresis.
This study will make available blood cell collections from volunteers genetically matched to various degrees with recipients in order to test and, if necessary, refine the process of removing white blood cell T-lymphocytes.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Family members of patients admitted to NHLBI allogeneic BMT protocols.
Age 18-65 .
Parent of patient (obligate haplotype match) OR HLA 3/6, 4/6/, 5/6/, or 6/6 match with patient.
Research apheresis available from patient.
EXCLUSION CRITERIA:
Pregnancy or lactation.
HLA type unknown.
More than one haplotype mismatch with patient .
History of any immunosuppressive disease
History of chronic viral antigenic stimulus
Venous access inadequate.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Volunteer
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Leukocyte Donors
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Family Members
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Leukocyte Collection
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No Reimbursement
- Recruitment Keyword(s):
-
None
- Condition(s):
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Graft vs Host Disease
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Hematologic Neoplasm
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Heart, Lung and Blood Institute
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Datta AR, Barrett AJ, Jiang YZ, Guimaraes A, Mavroudis DA, van Rhee F, Gordon AA, Madrigal A. Distinct T cell populations distinguish chronic myeloid leukaemia cells from lymphocytes in the same individual: a model for separating GVHD from GVL reactions.Bone Marrow Transplant. 1994 Oct;14(4):517-24.
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Mavroudis DA, Jiang YZ, Hensel N, Lewalle P, Couriel D, Kreitman RJ, Pastan I, Barrett AJ. Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.Bone Marrow Transplant. 1996 May;17(5):793-9.
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Mavroudis DA, Dermime S, Molldrem J, Jiang YZ, Raptis A, van Rhee F, Hensel N, Fellowes V, Eliopoulos G, Barrett AJ. Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions.Br J Haematol. 1998 Jun;101(3):565-70.
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