NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Mental Health (NIMH)

115 Protocols (103 Active Accrual of new subjects, 12 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 08-M-0196:
Investigation of the Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder

* 08-M-0190:
Effects of Chronic Musculoskeletal Pain and Opioidergic versus Placebo Interventions on Neuroendocrine Function in Men

* 08-M-0158:
PET Imaging of Peripheral Benzodiazepine Receptors Using [11C](R)-PK 11195 and [11C]PBR28

* 08-M-0154:
An Investigation of the Relationship Between Donepezil Enhanced REM Sleep, Sleep Architecture and Behavior in the Prepubertal Child with Autism

* 08-M-0150:
An Investigation to Determine Whether Levels of P11 Protein in Peripheral Blood Cells Correlate with Treatment Response to Citalopram in Patients with Major Depressive Disorder

* 08-M-0124:
Measurement of P-glycoprotein Function in Alzheimer Disease, Parkinson Disease, and Frontotemporal Dementia Using Positron Emission Tomography

* 08-M-0066:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in Dementia

* 08-M-0062:
Brain and Whole Body Imaging of P-Glycoprotein Function using [11C]dLop

* 08-M-0052:
fMRI Investigation of Cortical Reorganization and Phantom Limb Pain Following Amputation

* 08-M-0049:
Imaging of Cannabinoid CB1 Receptors Using [18F]MePPEP-d2

* 08-M-0048:
PET Test/Retest Brain Imaging of Cannabinoid CB1 Receptors Using [11C]MePPEP

* 08-M-0006:
PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Carotid Atherosclerosis

* 08-M-0002:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Atomoxetine on Cognitive Function in Patients with Schizophrenia and Normal Controls Based on COMT Genotype

* 07-M-0209:
PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Neurocysticercosis Using [F-18]FBR

* 07-M-0208:
PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Neurocysticercosis Using [C-11]PBR28

* 07-M-0201:
An Investigation of the Efficacy of the Glutamate Transporter GLT 1 in the Treatment of Bipolar Depression

* 07-M-0152:
An Investigation of the Antidepressant Effects of the Selective NR2B Antagonist MK-0657 in Major Depression

* 07-M-0127:
Functional Neuroanatomy of Emotion Perception, Recognition, Learning, and Memory

* 07-M-0082:
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203

* 07-M-0036:
PET Imaging of Brain Amyloid Using [11C]MeS-IMPY

* 07-M-0024:
Treatment of Childhood Regressive Autism with Minocycline: an Anti-Inflammatory Agent Active within the CNS

* 07-M-0021:
Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

* 06-M-0253:
Evaluation of the Efficacy of the NK1 Antagonist GR205171 in Posttraumatic Stress Disorder

* 06-M-0246:
PET Scanning of Brain Dopaminergic Signal Transduction Involving Arachidonic Acid in Adults with Attention Deficit Hyperactivity Disorder (ADHD)

* 06-M-0234:
The Antidepressant Efficacy of the Anticholinergic Scopolamine

* 06-M-0215:
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE 4) in Depressed Patients

* 06-M-0214:
PET Measurement of Regional Rates of Cerebral Protein Synthesis in Subjects with Fragile X Syndrome

* 06-M-0162:
An Investigation Examining the Evidence for Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder

* 06-M-0155:
Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood Disorders

* 06-M-0102:
Clinical and Immunological Investigations of Subtypes of Autism

* 06-M-0065:
The Evaluation of Patients with Autism Spectrum Disorders and Healthy Volunteers

* 06-M-0002:
PET Whole Body Biodistribution and Test Retest Brain Imaging Studies Using a Phosphodiesterase 4 Inhibitor (R)-[11C]rolipram

* 05-M-0225:
An Investigation of the Efficacy in Childhood Obsessive-Compulsive Disorder of Riluzole: An Antiglutamatergic Agent

* 05-M-0198:
Effect of D-cycloserine on Treatment of Social Phobia

* 05-M-0169:
Dopamine Receptor Imaging in Mood Disorders

* 05-M-0157:
Top-Down Attentional Control of Visual Processing

* 05-M-0147:
Investigating the Role of Norepinephrine in Emotional Processing through Alpha-2 Adrenergic Receptor Modulation

* 05-M-0144:
MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

* 05-M-0110:
Intermediate Phenotype and Genetic Mechanisms for Psychosis and Cognitive Disturbance in 22q11.2-Hemideletion Syndrome

* 05-M-0105:
Investigating the Neuro-Cognitive Underpinnings of the Emotional Dysfunction Linked to Childhood Behavioral Disturbance

* 05-M-0102:
Neurobiological Mechanisms in Panic Disorder: Behavioral, Genetic, & Neural Correlates of Noradrenergic Function

* 05-M-0059:
5HT1A and SERT Imaging During Pharmacologically Induced Hypogonadotropic Hypogonadism With and Without Estrogen and Progesterone Replacement

* 05-M-0035:
The Effects of Mood and Tryptophan Depletion on the Neural Correlates of Affective Shifting in Mood Disorders

* 05-M-0006:
The Effect of Gabapentin on Prefrontal GABA Concentration and Emotional Processing in Healthy Humans

* 04-M-0270:
Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion

* 04-M-0227:
Combining a Dopamine Agonist and Selective Serotonin Reuptake Inhibitor for Treatment of Depression: A Double-Blind, Randomized Study

* 04-M-0222:
Investigation of the Rapid (Next Day) Antidepressant Effects of an NMDA Antagonist

* 04-M-0221:
The Treatment of Menstrually-Related Mood Disorders with Extended Versus Interrupted Oral Contraceptives

* 04-M-0183:
Association Between Adenosine Receptor Gene Polymorphisms and Physiological Responses to Caffeine in Subjects with Panic Disorder and Healthy Controls

* 04-M-0160:
Neural Correlates of Depressive Symptoms and Reward Related Mechanisms Following AMPT Depletion in Remitted Depressed Patients Off Treatment and Healthy Controls

* 04-M-0139:
The Effects of Dutasteride on Mood, HPA Axis, and Serum Allopregnanolone Levels in Women with Menstrual-Related Mood Disorders and Controls

* 04-M-0091:
An Investigation of a Pharmacologic Strategy to Bring About Rapid (Next Day) Antidepressant Effects

* 04-M-0002:
The Functional Neuroanatomy of Emotion Regulation in Major Depressive Disorder (MDD)

* 03-M-0292:
Psychobiological Mechanisms of Resilience to Trauma

* 03-M-0211:
Family Study of Affective and Anxiety Spectrum Disorders

* 03-M-0186:
The Psychobiology of Temperament: An fMRI Study

* 03-M-0185:
Generalized Anxiety Disorder and Social Anxiety Disorder: Their Impact on the Processing of Social Emotional Information and Instrumental Learning

* 03-M-0175:
The Effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women with Perimenopausal Depression

* 03-M-0161:
The Efficacy of 17Beta-Estradiol in Postpartum-Related Depressive Illness

* 03-M-0149:
Functional MRI Study of Brain Mechanism Mediating Anhedonia in Major Depression

* 03-M-0143:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Modafinil on Cognitive Function in Patients with Schizophrenia and Normal Controls Based on COMT Genotype

* 03-M-0138:
A Screening Protocol to Evaluate Women with Postpartum-Related Mood and Behavioral Disorders

* 03-M-0108:
Cholinergic Modulation of Cognition and Emotion in Mood Disorders: Functional Neuroimaging Studies

* 03-M-0102:
Effects of Hydrocortisone Infusion on Processing of Facially Expressed Emotion During Functional Magnetic Resonance Imaging

* 03-M-0093:
Predictability and Aversive Expectancies in Anxiety Disorders

* 03-M-0092:
An Investigation of the Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression

* 03-M-0035:
Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-up for Childhood Onset Psychotic Disorders

* 03-M-0014:
Neural Circuitry and Risk for Depression in Adolescents: A Study Using Functional Magnetic Resonance Imaging

* 03-M-0001:
Muscarinic Cholinergic Receptor Imaging in Depression

* 02-M-0321:
fMRI Investigation of Explicit Cue and Contextual Fear

* 02-M-0263:
Psychopharmacology of Fear-Potentiated Startle in Humans

* 02-M-0239:
Randomized, Double-Blinded, Placebo Controlled Study of the Effects of Tolcapone and Entacapone on Cognitive Function in Patients With Schizophrenia and Normal Controls Based on COMT Genotype

* 02-M-0120:
The Efficacy of Phytoestrogens and Selective Estrogen Receptor Modulators in Perimenopause-Related Depression

* 02-M-0047:
Serotonin1A Receptor and Serotonin Transporter Imaging In Mood Disorders

* 02-M-0021:
Severe Mood and Behavioral Dysregulation in Children: Pathophysiology and Treatment with Lithium

* 02-M-0007:
Adolescent Medial Temporal Lobe Function in Health and Illness

* 02-M-0003:
Fear Conditioning Using Computer-Generated Virtual Reality

* 01-M-0254:
The Evaluation of Patients with Mood and Anxiety Disorders and Healthy Volunteers

* 01-M-0232:
Positron Emission Tomography (PET) Scanning in Dopamine Disorders: Parkinson's Disease and Schizophrenia

* 01-M-0192:
Fluoxetine's Effects on Attention and Emotional Memory in Anxious and Depressed Youth and Adults

* 01-M-0185:
Effects of Arousal and Stress on Classical Conditioning

* 01-M-0152:
Adolescence, Puberty, Hormones, and Emotion Regulation: An fMRI Study

* 00-M-0198:
The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder

* 00-M-0177:
Transcranial Magnetic Stimulation Studies of Visual Attention

* 00-M-0103:
The Treatment of Menstrually-Related Mood Disorders with Continuous Gonadal Steroid Replacement

* 00-M-0085:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 3.0 Tesla MRI and Magnetoencephalography

* 99-M-0172:
Integrating EEG/MEG and fMRI: Activity Correlation Between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers

* 96-M-0124:
Genetics of Obsessive-Compulsive Disorder: A Collaborative Study

* 95-M-0150:
A Neurobiological Investigation of Patients with Schizophrenia Spectrum Disorders and Their Siblings

* 95-M-0097:
An Endocrine Model For Postpartum Mood Disorders

* 93-M-0170:
Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

* 92-M-0174:
The Central Nervous System Effects of Pharmacologically Induced Hypogonadotropic Hypogonadism with and without Estrogen and Progesterone Replacement

* 91-M-0230:
Mechanisms of Individual Variation of Dextroamphetamine Effects in Normal Human Subjects

* 91-M-0124:
Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers with 1.5 Tesla MRI

* 90-M-0142:
Brain Procurement for the Neuropathology Section, CBDB

* 90-M-0088:
The Treatment of Menstrually-Related Mood Disorders with the Gonadotropin Releasing Hormone (GnRH) Agonist, Depot Leuprolide Acetate (Lupron)

* 90-M-0014:
Studies of Frontal Lobe Function During Cognitive Stimulation as Measured with Oxygen-15 Water Positron Emission Tomography in Normal Subjects and Patients with Neuropsychiatric Disorders

* 89-M-0160:
Inpatient Evaluation of Neuropsychiatric Patients

* 89-M-0006:
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Controls

* 88-M-0131:
The Evaluation of Women with Perimenopause-Related Mood and Behavioral Disorders

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