Protocol Number: 08-M-0049

Title:

Imaging of Cannabinoid CB1 Receptors Using [18F]MePPEP-d2

Number:

08-M-0049

Summary:

The purpose of this protocol is to measure brain CB1 receptors in the hope to better understand how they work, so that one day we can understand how the CB1 receptors are involved in psychiatric, neurological, and behavioral disorders.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

-All subjects must be healthy and aged 18-65 years, with history/physical exam, ECG, and laboratory tests within one year of the PET scan.

-The volunteer must sign an informed consent form.

EXCLUSION CRITERIA:

-Current psychiatric illness, substance abuse including marijuana use, or severe systemic disease based on history and physical exam.

-Laboratory tests with clinically significant abnormalities or positive urine toxicology screen.

-Prior participation in other research protocols in the last year such that radiation exposure would exceed the annual limits.

-Pregnancy and breast feeding.

-Claustrophobia.

-Presence of ferromagnetic metal in the body or heart pacemaker.

-Positive HIV test.

-Employee of the investigative site or an immediate family member of an employee of the investigative site. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.

-Employee of Eli Lilly and Company.

Special Instructions:

Currently Not Provided

Keywords:

CB1 Receptor

PET

Cannabinoid

[18F]FMPEP-d2

Brain Imaging

Recruitment Keyword(s):

Healthy Volunteer

HV

Condition(s):

CB1

Cannabinoid

PET

[18F]FMPEP-d2

Brain Imaging

Investigational Drug(s):

[18F]FMPEP-d2

Investigational Device(s):

None

Intervention(s):

Drug: [18F]FMPEP-d2

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Abi-Dargham A, Gandelman M, Zoghbi SS, Laruelle M, Baldwin RM, Randall P, Zea-Ponce Y, Charney DS, Hoffer PB, Innis RB. Reproducibility of SPECT measurement of benzodiazepine receptors in human brain with iodine-123-iomazenil. J Nucl Med. 1995 Feb;36(2):167-75.

Burger C, Buck A. Requirements and implementation of a flexible kinetic modeling tool. J Nucl Med. 1997 Nov;3 (11):1818-23.

Burns HD, Van Laere K, Sanabria-Boh—rquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, Van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, Jewell JP, Lin LS, Liu P, Goulet MT, Gottesdiener K, Wagner JA, de Hoon J, Mortelmans L, Fong TM, Hargreaves RJ. [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9800-5. Epub 2007 May 29.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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