Protocol Number: 08-M-0006

Title:

PET Imaging of Peripheral Benzodiazepine Receptors in Patients with Carotid Atherosclerosis

Number:

08-M-0006

Summary:

Inflammation in the vascular wall is important in atherosclerosis and the blockage of the artery. The peripheral benzodiazepine receptor is involved in inflammation and in this protocol we will attempt to take pictures, using PET camera, of inflammation in patients with atherosclerosis and compare those of healthy people.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA

Age 18 - 89

Ability to provide written informed consent

EXCLUSION CRITERIA

Severe systemic disease based on history, physical examination or laboratory tests that would prevent participation in the study

Prior participation in other research protocols in the last year such that radiation exposure would exceed the annual guideline of RSC

Pregnancy and breast feeding

Claustrophobia

Positive HIV test

Inability to lie flat for a few hours for the PET scans

Medically unstable

Any other condition which in the opinion of the PI would prevent satisfactory participation in and completion of the study.

Special Instructions:

Currently Not Provided

Keywords:

Inflammation

Unstable Plaque

Macrophage

Thrombosis

Autoradiography

Recruitment Keyword(s):

Parkinson Disease

PD

Condition(s):

Atherosclerosis

Healthy

Investigational Drug(s):

[C-11]PBR28

Investigational Device(s):

None

Intervention(s):

Drug: [C-11]PBR28

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Anholt RR, De Souza EB, Oster-Granite ML, Snyder SH. Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J Pharmacol Exp Ther. 1985 May;233(2):517-26.

Anholt RR, Murphy KM, Mack GE, Snyder SH. Peripheral-type benzodiazepine receptors in the central nervous system: localization to olfactory nerves. J Neurosci. 1984 Feb;4(2):593 603.

Banati RB. Visualising microglial activation in vivo. Glia. 2002 Nov;40(2):206-17. Review.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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