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Protocol Number:
07-CC-0125
- Title:
Pilot Study of the Incidence of HLA Class I and Class II Antibodies in Platelet Donors and their Effects on the Transfusion Recipient
- Number:
07-CC-0125
- Summary:
This study will determine if transfusion of platelets containing HLA antibodies (certain antibodies to white blood cells) are more likely to cause transfusion reactions than transfusion of platelets that do not contain HLA antibodies.
People 18 years of age or older who donate platelets at the NIH Clinical Center may be eligible for this study.
An extra tube of blood (about one teaspoon) is obtained from participating donors at the time of their donation at the NIH Platelet Center. The blood plasma in the extra tube is tested for HLA antibodies and antibodies to certain white blood cells called granulocytes. The research sample is assigned a code number for identification and sent to the HLA Laboratory in the Department of Transfusion Medicine.
- Sponsoring Institute:
-
National Institutes of Health Clinical Center (CC)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
1. Both male and female donors
2. Any ethnic group
3. 18 years of age or older
4. Must meet the criteria for donating platelets in the DTM
EXCLUSION CRITERIA:
1. Donors are not eligible to donate platelets in the DTM
- Special Instructions:
Currently Not Provided
- Keywords:
-
Human Leukocyte Antigens (HLA)
-
Transfusion Reactions
-
Platelet Donors
- Recruitment Keyword(s):
-
Platelet Donors
- Condition(s):
-
Healthy
-
Transfusion Reactions
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- Warren G. Magnuson Clinical Center
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D; National Heart, Lung and Blood Institute Working Group on TRALI. Transfusion-related acute lung injury: definition and review. Crit Care Med. 2005 Apr;33(4):721-6.
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Goldman M, Webert KE, Arnold DM, Freedman J, Hannon J, Blajchman MA; TRALI Consensus Panel. Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev. 2005 Jan;19(1):2-31.
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BRITTINGHAM TE. Immunologic studies on leukocytes. Vox Sang. 1957 Sep;2(4):242-8.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/17/2008
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