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The Center for Proteomics develops methods to help clarify the biological mechanisms
associated with toxicity using mass spectrometry-based proteomics. The
development of mechanisms to integrate proteomic data with that of other omics
data is underway. This work complements the development of software for
large-scale protein identification studies and is being extended to assist in
quantitative comparisons. This work is necessary to permit a higher sample
number to be examined to permit both dose and time studies in support of
toxicology studies. Initial work focused on improvements in throughput and
sensitivity of mass spectrometry-based proteomic experiments, as well as the
development of bioinformatics to handle the large volume of data that are
generated.
Contact Information
For more information, please contact Dr.
James Fuscoe, at 870-543-7126 or
james.fuscoe@fda.hhs.gov
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2007-OCT-04.