Human Health Effects Research Program
Sensitive Human Health Endpoints
Exposure to contaminants via consumption of Great Lakes fish over an extended period may increase the potential for adverse human health effects. The persistence and latency of some of these GL contaminants have been demonstrated to be important in their ability to cause adverse health effects (Humphrey, 1988; Johnson et al., 1998; Hicks, Cibulas, and De Rosa, 2000). Thus, the program has identified sensitive human health end points to be assessed. These include behavioral, reproductive, developmental, neurologic, endocrinologic, and immunologic measures. Future assessment may examine genetic end points and other sensitive biomarkers of exposure and or effect if warranted by the research findings.