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Research
- Branch Overview
- Chemical Immunology Section
- Genomic Integrity and Immunity Group
- Lymphocyte Cell Biology Section
- Molecular Inflammation Section
Molecular Immunology and Inflammation Branch
Investigator
Phone: 301-402-7858
Building: 10, Room: 13C103D
E-mail: casellar@mail.nih.gov
Dr. Rafael Casellas was born in Buenos Aires and lived in Geneva, Paris, and Helsinki before coming to the United States where he received his Bachelor of Science in Chemistry from Brigham Young University in 1996. He received a Ph.D. in Molecular Immunology from the Rockefeller University in 2002. There, he worked under Dr. Michel Nussenzweig studying the role of immunoglobulin gene expression and recombination in the establishment of B cell tolerance and peripheral activation. From 2002 to 2003 he did postdoctoral training with Nobel Laureaute David Baltimore at the California Institute of Technology. There Dr. Casellas continued his molecular studies of B cell activation and developed new mouse gene targeting techniques. In January 2004, Dr. Casellas moved to the Molecular Immunology Branch of the NIAMS as a tenure-track investigator to form the Genomic Integrity and Immunity Group. Dr. Casellas is also serving as an adjunct investigator at the Center for Cancer Research, NCI.
Other NIAMS Affiliations
Genomic Integrity and Immunity Group
Selected Publications
Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R,
Papavasiliou FN. MicroRNA-155 is a negative regulator of activation-induced
cytidine deaminase. Immunity. 2008 May;28(5):621-9. Epub 2008 May 1.
Jankovic M, Casellas R, Yannoutsos N, Wardemann H, Nussenzweig MC. RAGs and Regulation of Autoantibodies. Annu Rev Immunol. 2004; 22: 485-501.
Casellas R, Jankovic M, Meyer G, Gazumyan A, Luo Y, Roeder R, Nussenzweig M. OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes. Cell. 2002; 110(5): 575-85.
Petersen S*, Casellas R*, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A. AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001; 414(6864): 660-5. *First author equal contribution.
Casellas R, Shih TA, Kleinewietfeld M, Rakonjac J, Nemazee D, Rajewsky K, Nussenzweig MC. Contribution of receptor editing to the antibody repertoire. Science. 2001; 291(5508):1541-4.
