Cancer Genetics
Network
A Resource For Investigators Studying Inherited Predisposition to Cancer
The Cancer Genetics Network (CGN) is a national network of centers
specializing in the study of inherited predisposition to cancer. The
resource is available to the research community at large to support studies
on the:
- genetic basis of human cancer susceptibility,
- integration of this information into medical practice, and
- behavioral, ethical, and public health issues associated with human
genetics.
[ D] December 2007
The database has information on 24,000 individuals (16,000 families) with
cancer and/or a family history of cancer. Data are available on cancer
type, a 4-generation cancer family history, genetic testing (if performed),
genetic mutation if collected in a CGN special study, any known genetic
syndromes in the family, biospecimens on many enrollees, annual follow-up
on all enrollees, history of tobacco use, and sociodemographic information.
In addition, more data are available on subsets of enrollees who have participated
in CGN special studies. The population enrolled makes possible research
on both common and uncommon tumors.
This unique infrastructure enables studies on genes of moderate and
low penetrance, as well as more easily identified high penetrance genes.
The CGN welcomes opportunities to collaborate with research groups on
important studies, and/or it can provide data and biospecimens, and a range
of services and expertise to support independent studies. Research
funding is not provided.
The CGN is supported through a 5-year contract awarded to Massachusetts
General Hospital (MGH) in the Spring of 2007 by NCI’s Epidemiology
and Genetics Research Program (EGRP). MGH is the Data Coordinating
Center and subcontracts with 14 centers that provide the infrastructure
to support studies. Diane M. Finkelstein, Ph.D., is MGH Program Manager/Principal
Investigator, and Nora Horick, M.S., is MGH Project Manager. Visit
MGH’s CGN Web site to learn more about using this research resource.
NCI began the CGN in 1998 through a group of cooperative agreements funded through EGRP.
Carol Kasten, M.D., Project Officer, Cancer Genetics
Network
Epidemiology
and Genetics Research Program
Division of Cancer Control and Population Sciences
National Cancer Institute
Tel: 301-402-8212
Fax: 301-435-5477
E-mail: kastenca@mail.nih.gov
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Contractor Web Site (MGH)
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