Probing Unexpected Connections Between Cell Cycle Control and Pre-mRNA Splicing |
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| Play: | http://videocast.nih.gov/launch.asp?12299
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| Air date: | Friday, November 05, 2004, 9:45:00 AM |
| Category: | Proteomics |
| Runtime: | 0:51:24 |
| NLM Title: | Probing unexpected connections between cell cycle control and pre-mRNA splicing [electronic resource] / Kathleen Gould. |
| Author: | Gould, Kathleen. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2004] |
| Abstract: | (CIT): The fission yeast cdc5 gene was identified in a genetic screen for mutants defective in cell cycle progression. Since that time, our laboratory and others have found that Cdc5p and its orthologs in other organisms including human are essential components of a subcomplex of the spliceosome termed the nineteen complex (NTC). Using Cdc5p as a target for tandem affinity purification, we have determined the composition (by mass spectrometry) and structure (by cryo-electron microscopy) of the assembled spliceosome. |
| Subjects: | Cell Cycle Proteins Cell Cycle Genes, cdc RNA Splicing Spliceosomes |
| Publication Types: | Government Publications Lectures |
| Rights: | This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely. |
| NLM Classification: | QU 375 |
| NLM ID: | 101268606 |
| CIT File ID: | 12299 |
| CIT Live ID: | 3682 |
| Permanent link: | http://videocast.nih.gov/launch.asp?12299 |
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