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Research
Cartilage Biology and Orthopaedics Branch
Staff Scientist
Phone: 301-451-1206
Building: 10-CRC, Room: 1-5256
E-mail: chenf1@mail.nih.gov
Dr. Faye H. Chen received her bachelor’s degree in Cell Biology from the University of Science and Technology of China. She went on to obtain her Ph.D. from the University of Wisconsin-Madison and started working on the biology of extracellular matrix protein including thrombospondins with Dr. Deane Mosher. After her postdoctoral training with Dr. Jack Lawler at Beth Israel Deaconess Medical Center/Harvard Medical School, she became assistant professor and head of Biochemistry of Orthopaedic Surgery at Columbia University. She moved to NIH and is currently staff scientist in the Cartilage Biology and Orthopaedics Branch at NIAMS.
Dr. Chen’s major research interests relate to the basic cellular and molecular mechanisms governing cartilage homeostasis and differentiation, with a focus on the roles of extracellular matrix and epigenetic control and signaling in cartilage biology and adult stem cell differentiation, and their application to tissue engineering. The projects that she is working on and involved in concern the roles of the extracellular matrix (especially cartilage oligomeric matrix protein) and mechanical stimulation in cartilage development and differentiation, and the mechanisms of mesenchymal stem cell maintenance and differentiation, specifically through regulation of epigenetic events.
Selected Publications
Chen, F.H., M.E. Herndon, N. Patel, J.T. Hecht, R.S. Tuan, and J Lawler: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem, 282:24591-98, 2007
Ishii, Y., A.O. Thomas, G.A. Ateshian, X.E. Guo, C.T. Hung, and F.H. Chen: Localization and distribution of cartilage oligomeric matrix protein in spine. Spine. 31:1539-46, 2006
Chen, F.H., K.T. Rousche, and R.S. Tuan: Tchnology Insight: adult stem cells in cartilage regeneration and tissue engineering. Nature Clin Pract Rheum.2:373-82, 2006.
Chen, F.H., A. O. Thomas, M. B. Goldring and J Lawler: Cartilage oligomeric matrix protein supports chondrocyte attachment though interaction with integrin. J Biol Chem. 280:32655-61, 2005
Chen, H., M. Deere, J.T. Hecht, and J. lawler. Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. J. Biol Chem. 275: 26538-26544, 2000.
