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Understanding Cancer Series: Cancer Genomics
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    Posted: 01/28/2005    Reviewed: 09/01/2006
Cancer Genomics

      Slide Number and Title
  1. What Is the Human Genome? 1
  2. Cancer Genomics 2
  3. A Sample Human Genome 3
  4. Genes: Keepers of the Code 4
  5. Noncoding Regions 5
  6. Genes to mRNA to Proteins 6
  7. RNA Processing Before Translation 7
  8. Triplet Code 8
  9. Mutations 9
  10. Mutations: Somatic and Germline 10
  11. Tumors Are Clonal 11
  12. Somatic Mutations 12
  13. Mitosis and Somatic Mutations 13
  14. Meiosis and Germline Mutations 14
  15. Recombination: Crossing Over 15
  16. De Novo Mutations 16
  17. Point Mutations 17
  18. Frameshift Mutations 18
  19. Splice-Site Mutations 19
  20. Regulatory Mutations 20
  21. SNPs: Frequently Occurring Genetic Variants 21
  22. Large Deletions or Insertions 22
  23. Example: Translocation of Bcr-Abl Genes 23
  24. Cancer-Associated Mutations 24
  25. Genotypes and Phenotypes 25
  26. Alleles 26
  27. Same Allele, Different Locus, Different Phenotype 27
  28. Different Locus, Different Allele, Same Phenotype 28
  29. Penetrance 29
  30. Factors Influencing Penetrance 30
  31. Age-Related Penetrance 31
     
  1. Epigenetic Factors and Penetrance 32
  2. Epigenetic Example: Methylation Alters Gene Expression 33
  3. Imprinting Alters Gene Expression 34
  4. Carrier Frequency 35
  5. Prevalence and Founder Effect 36
  6. Example: Founder Effect in Ashkenazi Jewish Population 37
  7. Mutations in Cancer Susceptibility Genes: BRCA1 38
  8. Mutations in Cancer Susceptibility Genes: BRCA2 39
  9. Autosomal Dominant Inheritance 40
  10. Examples of Dominantly Inherited Cancer Syndromes 41
  11. Cancer Susceptibility: Incomplete Penetrance and Phenocopies 42
  12. Example: BRCA1-Linked Hereditary Breast and Ovarian Cancer 43
  13. Example: BRCA2-Linked Hereditary Breast Cancer 44
  14. Autosomal Recessive Inheritance 45
  15. Some Recessively Inherited Cancer Syndromes 46
  16. X-Linked Inheritance 47
  17. Other Genetic Conditions Linked to Increased Cancer Risk 48
  18. Normal Cell Growth: The Cell Cycle 49
  19. Abnormal Cell Growth: Oncogenes 50
  20. Tumor Suppressor Genes 51
  21. Mutations in Tumor Suppressor Genes 52
  22. Two-Hit Hypothesis 53
  23. Loss of Heterozygosity 54
  24. Heterozygous Condition 55
  25. Repair Failure 56
  26. Cancer Susceptibility: Much Still Unknown 57
  27. Epigenetic Changes: Much Still Unknown 58
  28. Other Cancer-Associated Mutations: Much Still Unknown 59
  29. Other Cancer-Associated Mutations: Much Still Unknown (cont.) 60
  30. A Daunting Challenge 61


Table of Links

1http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide1
2http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide2
3http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide3
4http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide4
5http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide5
6http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide6
7http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide7
8http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide8
9http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide9
10http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide10
11http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide11
12http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide12
13http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide13
14http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide14
15http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide15
16http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide16
17http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide17
18http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide18
19http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide19
20http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide20
21http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide21
22http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide22
23http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide23
24http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide24
25http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide25
26http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide26
27http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide27
28http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide28
29http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide29
30http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide30
31http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide31
32http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide32
33http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide33
34http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide34
35http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide35
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37http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide37
38http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide38
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40http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide40
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44http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide44
45http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide45
46http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide46
47http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide47
48http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide48
49http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide49
50http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide50
51http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide51
52http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide52
53http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide53
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56http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide56
57http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide57
58http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide58
59http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide59
60http://cancer.gov/cancertopics/understandingcancer/cancergenomics/Slide60
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