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The 22nd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design 06/26/2008 to 06/27/2008
Lister Hill Auditorium
Bethesda, Maryland

Agenda

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The 22nd Annual Meeting of the Groups Studying the Structures of AIDS-Related Systems and Their Application to Targeted Drug Design

06/26/2008 - 06/27/2008

Agenda

 
THURSDAY, JUNE 26
 
 
8:00 – 8:30      Registration
 
8:30 – 8:35      Ravi Basavappa (NIGMS)
                        Welcome/Opening Remarks
 
8:35 – 945       Angela Gronenborn (University of Pittsburgh)
The Pittsburgh Center for HIV Protein Interactions: Studies of HIV infection, post- entry to integration
 
Chris Aiken (Vanderbilt University)
Structural Analysis of Capsid – Cyclophilin A interactions: Evidence for a Novel Restriction
 
Simon Watkins (University of Pittsburgh)
Tools and Methods for Imaging HIV in Living Cells
 
9:45 – 10:55    Wes Sundquist (University of Utah)
The CHEETAH Center
 
 
10:55 – 11:15 BREAK
 
 
11:15 – 12:25 Alan Frankel (University of California, San Francisco)
HARC Center Overview and Progress on Tat and Rev
Complexes
 
                        Matija Peterlin (University of California, San Francisco)
                        HIV Accessory and Regulatory Complexes: Tat, Nef, Vif
 
                        Robert Stroud (University of California, San Francisco)
                        HIV Integrase - DNA and Complexes
 
 
12:25 – 1:30    LUNCH
 
 
1:30 – 3:30      POSTER SESSION
 
 
3:30 – 4:10      Celia Schiffer (University of Massachusetts Medical School)
                        Targeting Drug Resistance in HIV-1 Protease
 
4:10 – 4:40      Stephen Goff (Columbia University/ HHMI)
                        Retroviral Restriction Factors: New Aspects of Innate Immunity
 
4:40 – 5:00      Yong Xiong (Yale University)
Structural Insight into the HIV Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly
 
5:00 – 5:20      Stanley Opella (University of California, San Diego)
                        Structure, Dynamics, and Drug-binding to the Viroporins Vpu of
                        HIV-1 and p7 of HCV
 
5:20                 Adjourn for day
 
 
 
FRIDAY, JUNE 27
 
8:30 – 8:35      Diana Finzi (National Institute of Allergy and Infectious Diseases)
                        Introduction to special session on genome-wide siRNA – based
                        screening of HIV – host interactions
 
8:35 – 9:05      Derek Dykxhoorn (Harvard Medical School)
A functional genomic approach for the identification of host proteins required for HIV infection
 
9:05 – 9:35      Amy Espeseth (Merck and Company)
                        Novel Host Factor Requirements for HIV Replication Identified via
                        siRNA screens
 
9:35 – 10:05  Sumit Chanda (The Burnham Institute)
Global analysis and Characterization of Host-Pathogen Interactions which regulate early stage HIV-1 replication
 
 
10:05 – 10:25 BREAK
 
 
10:25 – 10:55 Sriram Subramaniam (National Cancer Institute)
                        3D structure of native HIV-1 gp120 trimers and mechanisms of
                        cellular entry
 
10:55 – 11:25 Hiroshi Matsuo (University of Minnesota)
Structural Studies of the Deaminase Domain of APOBEC3G
 
11:25 – 12:05 Art Olson (The Scripps Research Institute)
                        Resistance Driven Structural Design for HIV Therapeutics
                        – Program Overview
 
                        Bruce Torbett (The Scripps Research Institute)
                        Resistance-Driven Approaches to HIV Protease Inhibition:
                        Structure and Biology
 
                        Richard Belew (University of California, San Diego)
Analysis of clinically-observed HIV evolution in response to alternative inhibitors via a probabilistic graph
 
Valery Fokin (The Scripps Research Institute)
Novel 1,2,3-Triazole-Based Inhibitors of HIV Protease
 
 
12:05 – 1:00    LUNCH
 
 
1:00 – 2:00      POSTER SESSION
 
 
2:00 – 2:20      Rob Rizzo (Stony Brook University)
                        Origins of Resistance to Peptide Inhibitors of HIVgp41
 
2:20 – 2:40      David Green (Stony Brook University)
Carbohydrate recognition by anti-viral proteins
                       
2:40 – 3:20      Irwin Chaiken (Drexel University)
                        Structure-Based Antagonism of HIV-1 Envelope Function in
                        Cell Entry
 
                        Joseph Sodroski (Harvard Medical School)
                        Interaction of Small-Molecule CD4 Mimics with a Highly
                        Conserved Pocket on the Human Immunodeficiency
                        Virus gp120 Envelope Glycoprotein
 
 
3:20 – 3:40      BREAK
 
 
3:40 – 4:00      TN Bhat (National Institute of Standards and Technology)
                        A Cross-referencing Web Resource of Pre-clinical Data for AIDS
 
4:00 – 4:20      Miriam Gochin (Touro University)
Exploration of small molecule libraries for gp41 inhibitors using a rapid fluorescence screening assay
 
4:20 – 4:40      Sergei Nekhai (Howard University)
                        Regulation of HIV-1 Transcription by cellular iron and hypoxia:
                        role of CDK2 and PP1
 
4:40 – 5:00      Rui Gong (National Cancer Institute)
                        Engineered Human Antibody Constant Domains with Increased
                        Stability
 
5:00                 Adjourn Meeting

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