Definition of germline mutation - NCI Dictionary of Cancer Terms

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germline mutation (...myoo-TAY-shun)

A gene change in a body's reproductive cell (egg or sperm) that becomes incorporated into the DNA of every cell in the body of the offspring. Germline mutations are passed on from parents to offspring. Also called hereditary mutation.

Previous Definitions:	germ-free, German chamomile, German Commission E, germinoma, germline DNA
Next Definitions:	Gerota's capsule, Gerota's fascia, Gerson therapy, gestational trophoblastic disease, gestational trophoblastic tumor