Document Type:
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Journal Article
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Center:
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NWFSC
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Document ID:
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6752
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Author:
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L. L. Johnson, D. P. Lomax, M. S. Myers, O. P. Olson, S. Y. Sol, S. M. O'Neill, J. E. West, T. K. Collier
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Year:
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In press
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Title:
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Xenoestrogen Exposure and Effects in English Sole (Parophrys vetulus) from Puget Sound, WA
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Journal:
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Aquatic Toxicology
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Volume:
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88
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Pages:
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29-38
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Keywords:
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English sole, vitellogenin, xenoestrogen, endocrine disruptor, Puget Sound
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Abstract:
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Vitellogenin, a yolk protein produced in the liver of oviparous animals in response to estrogens, normally
occurs only in sexually mature females with developing eggs. However, males can synthesize vitellogenin
when exposed to environmental estrogens, making the abnormal production of vitellogenin in male animals
a useful biomarker for xenoestrogen exposure. In 19972001, as part of theWashington States Puget
Sound Assessment and Monitoring Program,we surveyed English sole from a number of sites for evidence
of xenoestrogen exposure, using vitellogenin production in males as an indicator. Significant levels of vitellogenin
were found in male fish from several urban sites, with especially high numbers of fish affected
in Elliott Bay, along the Seattle Waterfront. Intersex fish were rare, comprising only two fish out of more
than 2900 examined. Other ovarian and testicular lesions, including oocyte atresia, were also observed,
but their prevalence did not appear to be related to xenoestrogen exposure. However, at the Elliott Bay
sites where abnormal vitellogenin production was observed in male sole, the timing of spawning in both
male and female English sole appeared altered. Sources of xenoestrogens and types of xenoestrogens present in Elliott Bay are poorly documented, but the compounds are likely associated with industrial discharges, surface runoff, and combined sewer outfalls.
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Divisions:
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EC
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Projects:
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