Funding

Systemic Autoimmune Disease Biology Program

Updated September 1, 2007

Research Areas

  • Basic and translational studies of systemic lupus erythematosus (SLE), systemic scleroderma (SSc), and autoimmune myositis
  • Animal models of disease
  • Genetic studies to discover and evaluate candidate pre-disposing genes; B and T cell development, differentiation, homeostasis, and tolerance; role of regulatory T cells
  • Interactions between antigen presenting cells, such as dendritic cells, and T cells
  • Cross-talk between immune cells and fibroblasts
  • Molecular events involved in the exaggerated production of collagen and in microvascular abnormalities seen in SSc
  • Involvement of TLRs and innate immunity, Fcgamma receptors, and immune complexes on disease etiology and pathology
  • Studies of apoptosis and clearance of apoptotic bodies
  • Pathophysiology of disease-associated autoantibodies
  • Basic research on treatments

Staff Contact

Marie Mancini, Ph.D.
Program Director
Systemic Autoimmune Disease Biology Program
Division of Skin and Rheumatic Diseases
NIAMS, NIH, DHHS
One Democracy Plaza
6701 Democracy Blvd. Ste. 800
Bethesda, MD 20892-4872
Email: mancinim2@mail.nih.gov