Curriculum Vitae

Cellular, Tissue and Gene Therapies Advisory Committee

CURRICULUM VITAE AND BIBLIOGRAPHY

July 1, 2005

NAME: Savio Lau-Ching Woo
BIRTHDATE: ----------------
GENDER: Male
MARITAL STATUS: --------------------
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CITIZENSHIP: ---------------------
SOCIAL SECURITY NUMBER: ------------
CURRENT PROFESSIONAL TITLE Professor and Founding Chairman
Department of Gene and Cell Medicine,
Mount Sinai School of Medicine, New York City.

EDUCATIONAL BACKGROUND

1. Salesian High School, Island Road, Hong Kong
  Graduation Date: June, ----
2. Loyola College, Montreal, Quebec, Canada
  Graduation Date: May, ----
  Degree Obtained: B.Sc. in Hons. Chemistry
3. University of Washington, Seattle, Washington, U.S.A.
  Graduation Date: August, ----
  Degree Obtained: Ph.D. in Biochemistry
  Thesis Advisor: Professor Earl W. Davie
  Thesis Title: The Effect of Cyclic AMP and Rabbit Skeletal Muscle Protein Kinase on E. Coli DNA-Dependant RNA Polymerase

PROFESSIONAL EXPERIENCE

1. Division of Neurological Sciences, University of British Columbia, Vancouver, B.C., Canada.
  1971- 1973 Post-Doctoral Fellow
2. Department of Cell Biology, Baylor College of Medicine, Houston, Texas.
  1973- 1974 Research Associate
  1974- 1975 Instructor
  1975- 1978 Assistant Professor
  1979- 1983 Associate Professor
  1984- 1996 Professor
3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
  1985-1996 Professor
4. Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX.
  1987-1994 Founding Director
5. Center for Gene Therapy, Baylor College of Medicine, Houston, TX.
  1991-1995 Founding Director
6. Howard Hughes Medical Institute, Bethesda, MD.
  1976-1978 Associate Investigator
  1978-1996 Investigator
7. Institute of Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, NY.
  1996-2004 Professor and Founding Director
8. Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY.
  2004- Professor and Founding Chairman

HONORS AND AWARDS:

  1. Undergraduate Scholarship 1963-1966; Winner of "Chemcell Prize" 1966.
  2. Board of Directors, Metropolitan Houston Chapter of National Foundation -March of Dimes, 1979-1987.
  3. Noel Rain Memorial Award, The Society for the Study of Inborn Errors of Metabolism, 1983.
  4. Honorary Membership, the Japanese Society of Inherited Metabolic Disease, 1986.
  5. MERIT Award "Phenylketonuria and the Phenylalanine Hydroxylase Gene" (R37-HD-17711) from the National Institute of Child Health and Human Development, 1988-1998.
  6. Board of Scientific Counselors, National Institute of Child Health and Human Development, 1988-1994.
  7. Research for Development Award from UNICEF of the United Nations, 1989.
  8. President, Society of Chinese Bioscientists in America, 1989-1990.
  9. Board of Directors, American Society of Human Genetics, 1994-1997.
  10. Secretary, Harvey Society, New York, 1998–2002.
  11. National Hemophilia Foundation Researcher of the Year Award, 1999.
  12. Chinese American Medical Society Scientific Award, 2000.
  13. President (1999), Founding Board of Directors (1996-1999) and Chairman of the Advisory Board (2002-2004), American Society for Gene Therapy.
  14. Chairman, Scientific Council, Alliance for Cancer Gene Therapy, 2002-
  15. Board of Directors, International Society for Cancer Gene Therapy, 2006-2009.

MEMBERSHIPS ON GRANT STUDY SECTIONS AND TASK FORCES

  1. Grant Review Committee, Cystic Fibrosis Foundation, 1981-1986.
  2. NIH Grant Study Section on Physiological Chemistry, 1983.
  3. NIH Grant Study Section on Molecular Biology, 1983-1985.
  4. Chairman, Ad Hoc NIH Study Section on Gene Therapy Vector Development, 1997.
  5. Chairman, Ad Hoc NIH Study Section on Gene Therapy Core Center, 1998.
  6. Task Force on Financial Conflicts of Interest in Clinical Research of the Association of American Medical Colleges (AAMC), 2001-2002.

MEMBERSHIP ON EDITORIAL BOARDS OF PROFESSIONAL JOURNALS:

  1. Associate Editor, Am. J. Hum. Genet., 1985 - 1988.
  2. Editorial Board, Journal of Molecular Neuroscience, 1989-1992.
  3. Editorial Advisory Board, Biochemistry , 1989 - 1993.
  4. Editorial Board, Journal of Biological Chemistry, 1992- 1994.
  5. Editorial Board, Genomics, 1987 - 1995.
  6. Editorial Board, Human Mutation, 1990 - 1995.
  7. Editorial Board, DNA, 1983 -1999.
  8. Editorial Board, Somatic Cell & Molecular Genetics, 1989-1999.
  9. U.S. Associate Editor, Gene Therapy, 1995-1998.
  10. Editorial Board, Human Gene Therapy, 1995-present.
  11. Associate Editor, Cancer Research, 1999 - 2002.
  12. Editorial Board, Molecular Therapy, 2000-present.

MAJOR PROFESSIONAL MEETINGS ORGANIZED:

  1. Founding Chairman, Gordon Research Conference entitled "Molecular Genetics" in Colby Sawyer College, New Hamshire on July 1-5, 1985.
  2. Co-Chairman, Searle UCLA Symposium entitled "Amino Acids in Health and Disease: New Perspectives" in Keystone, Colorado on May 30-June 4, 1986.
  3. Chairman, the Third SCBA International Symposium and Workshop in Hong Kong on June 24-30, 1990.
  4. Chairman, Cold Spring Harbor Laboratories Meeting entitled "Regulation of Liver Gene Expression in Health & Disease" in CSHL on May 5-9, 1993.
  5. Chairman, Program Committee on Science Innovation, Annual Meeting of AAAS:
    6. 1993 in Boston
    1995 in Atlanta
    1996 in Baltimore
    1997 in Seattle
  6. Chairman, Keystone Symposium entitled "Gene Therapy and Molecular Medicine" in Steamboat Spring, Colorado on March 26-April 1, 1995.
  7. Chairman, The Third Annual Meeting of the American Society for Gene Therapy in Denver, Colorado on May 31 – June 4, 2000.
  8. Founding Director, Clinical Gene Transfer Training and Comprehensive Review Course, co-sponsored by The American Society for Gene Therapy, The Food and Drug Administration, The Office of Human Research Protection and The Office of Biotechnology Activities at the NIH in Seattle, Washington in May, 2001, Boston in June, 2002 and Washington, DC in June, 2003.

PROFESSIONAL SOCIETY MEMBERSHIPS:

  1. The American Society for Cell Biology
  2. The American Society of Human Genetics
  3. The American Society of Biochemistry and Molecular Biology
  4. The Society for the Study of Inborn Errors of Metabolism
  5. The Society of Inherited Metabolic Disorders
  6. The American Federation for Clinical Research
  7. The Human Genome Organization
  8. The American Association for the Advancement of Science
  9. The American College of Medical Genetics
  10. The American Association for Cancer Research
  11. The Harvey Society
  12. The American Society for Gene Therapy

PUBLICATIONS

Original Articles in Peer-Reviewed Journals

  1. Martelo, O.J., Woo, S.L.C., Teimann, E.M. and Davie, E.W. 1970. Effect of protein kinase on RNA polymerase. Biochemistry 9:4807.
  2. Martelo, O.J., Woo, S.L.C. and Davie, E.M. 1974. Further studies on the phosphorylation of RNA polymerase. J. Mol. Biol. 87:685.
  3. Gillum, S., Woo, S.L.C. and Woolf, L.I. 1974. Properties of phenylalanine hydroxylase from human fetal liver. Biochem. J. 139:740.
  4. Woo, S.L.C., Gillum, S. and Woolf, L.I. 1974. Purification and characterization of phenylalanine hydroxylase from human fetal liver. Biochem. J. 139:740.
  5. Woo, S.L.C., Harris, S.E., Rosen, J.M., Chan, L., Sperry, P.J., Means, A.R. and O'Malley, B.W. 1974. Use of sepharose 4B for preparative scale fractionation of eukaryotic messenger RNAs. Preparative Biochemistry 4:555.
  6. Rosen, J.M., Woo, S.L.C., Holder, J.W., Means, A.R. and O'Malley, B.W. 1975. Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. Biochemistry 14:69.
  7. Means, A.R., Woo, S.L.C., Harris, S.E. and O'Malley, B.W. 1975. Estrogen induced ovalbumin messenger RNA. Molec. Cell Biochem. 7:33.
  8. Woo, S.L.C., Rosen, J.M., Liarakos, C., Robberson, D.L., Choi, Y.C., Means, A.R. and O'Malley, B.W. 1975. Physical and chemical characterization of purified ovalbumin messenger RNA. J. Biol. Chem. 250:7027.
  9. Rosen, J.M., Woo, S.L.C. and Comstock, J.P. 1975. Regulation of casein messenger RNA in rat mammary gland. Biochemistry 14:2895.
  10. Van, N.T., Holder, J.W., Woo, S.L.C., Means, A.R. and O'Malley, B.W. 1976. Secondary structure in ovalbumin messenger RNA. Biochemistry 15:2054.
  11. Bullock, D.W., Woo, S.L.C. and O'Malley, B.W. 1976. Uteroglobin messenger RNA translation in vitro. Biology of Reproduction 15:435.
  12. Monahan, J.J., Harris, S.E., Woo, S.L.C. and O'Malley, B.W. 1976. The synthesis and properties of the complete transcript of ovalbumin messenger RNA. Biochemistry 15:223.
  13. Woo, S.L.C., Smith, R., Means, A.R. and O'Malley, B.W. 1976. The ovalbumin gene. I. Partial purification of the coding strand. J. Biol. Chem. 251:3868.
  14. Sperry, P.J., Woo, S.L.C., Means, A.R. and O'Malley, B.W. 1976. Partial purification and progesterone induction of avidin messenger RNA. J. Biol. Chem. 99:315.
  15. McReynolds, L.A., Monahan, J.J., Bendure, D.W., Woo, S.L.C., Paddock, G.V., Salser, W., Dorson, J., Moses, R.E. and O'Malley, B.W. 1976. The ovalbumin gene: Insertion and transcription of ovalbumin gene sequences in chimeric bacterial plasmids. J. Biol. Chem. 252:1840.
  16. Van, N.T., Monahan, J.J., Woo, S.L.C., Means, A.R. and O'Malley, B.W. Comparative studies on the secondary structures of ovalbumin messenger RNA and its complementary DNA transcript. Biochemistry 16:4090.
  17. Monahan, J.J., Woo, S.L.C., Liarakos, C. and O'Malley, B.W. 1977. The ovalbumin gene. lV. Action of restriction endonucleases upon DNA coding sequence. J. Biol. Chem. 252:4722
  18. Woo, S.L.C., Monahan, J.J. and O'Malley, B.W. 1977. The ovalbumin gene. V. Purification of the anti-coding strand. J. Biol. Chem. 252:5789.
  19. Woo, S.L.C., Chandra, T., Means, A.R. and O'Malley, B.W. 1977. The Ovalbumin gene. VI. Purification of the coding strand. Biochemistry 16:5670.
  20. Lingappa, V.P., Shields, D., Woo, S.L.C. and Blobel, G. 1978. Evidence for the presence of an uncleaved signal sequence in nascent chicken ovalbumin. J. Cell Biol. 79:567.
  21. Lai, E.C., Woo, S.L.C., Dugaiczyk, A., Catterall, J.F. and O'Malley, B.W. 1978. The Ovalbumin gene. VIII. Structural sequences in native chick DNA are not contiguous. Proc. Natl. Acad. Sci. U.S.A. 75:2205.
  22. Woo, S.L.C., Dugaiczyk, A., Tsai, M.J., Lai, E.C., Catterall J.F. and O'Malley, B.W. 1978. The ovalbumin gene. lX. Cloning of the natural gene. Proc. Natl. Acad. Sci. U.S.A. 75:3688.
  23. Dugaiczyk, A., Woo, S.L.C., Lai, E.C., Mace, M.L., Jr., McReynolds, L. and O'Malley, B.W. 1978. The natural ovalbumin gene contains seven introns. Nature 274:328.
  24. Stein, J.P., Catterall, J.F., Woo, S.L.C., Means, A.R. and O'Malley, B.W. 1978. Molecular cloning of ovomucoid gene sequences from partially purified ovomucoid messenger RNA Biochemistry 17:5763.
  25. Lai, E.C., Woo, S.L.C., Dugaiczyk, A. and O'Malley, B.W. 1979. The ovalbumin gene. XI. Alleles created by mutations in the intervening sequences of the natural gene. Cell 16:201.
  26. Catterall, J.F., Stein, J.P., Lai, E.C., Woo, S.L.C., Dugaiczyk, A., Mace, M.L., Jr., Means, A.R. and O'Malley, B.W. 1979. The natural chick ovomucoid gene contains at least six intervening sequences. Nature 278:323.
  27. Dugaiczyk, A., Woo, S.L.C., Colbert, D.A., Lai, E.C., Mace, M. and O'Malley, B.W. 1979. The ovalbumin gene XII: Cloning and molecular organization of the entire ovalbumin gene. Proc. Natl. Acad. Sci. 76:2253.
  28. Lai, E.C., Catterall, J.F., Stein, J.P., Woo, S.L.C., Mace, M.L., Jr., Means, A.R. and O'Malley, B.W. 1979. Structure of the natural chick ovomucoid gene and its flanking sequences. Cell 18:829.
  29. Woo, S.L.C., Tsai, S.Y. Tsai, M.J., Mace, M.L. and O'Malley, B.W. 1979. Cloning and expression of a pseudo-ovalbumin gene. Biochem. Biophys. Res. Commun. 89:997.
  30. Lai, E.C., Woo, S.L.C., Riser, M.E., Fraser, T.H. and O'Malley, B.W. 1980. ovalbumin is synthesized in mouse L cells transformed with the natural ovalbumin gene. Proc. Natl. Acad. Sci. U.S.A. 77:244.
  31. Wickens, M.P., Woo, S.L.C., O'Malley, B.W. and Gurden, J.B. 1980. Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei. Nature, 285:628.
  32. Colbert, D.A., Knoll, B.J., Woo, S.L.C., Tsai, M.J., Mace, M.L. and O'Malley, B.W. 1980. Differential hormonal responsiveness of the authentic and pseudo-ovalbumin genes. Biochemistry 19:5586.
  33. MacGillivray, R.T., Friezner Dege, S.J., Chandra, T., Woo, S.L.C. and Davie, E.W. 1980. Cloning and analysis of a cDNA coding for bovine prothrombin. Proc. Natl. Acad. Sci. 77:5153-5157.
  34. Chandra, T., Woo, S.L.C. and Bullock, D. 1980. Cloning of rabbit uterglobin structural gene. Biochem. Biophys. Res. Commun. 95:197-204.
  35. Munjaal, R.P., Chandra, T., Woo, S.L.C., Dedman, J.R. and Means, A.R. 1980. A clones calmodulin structural gene probe is complementary to DNA sequences from diverse phyla. Proc. Natl. Acad. Sci. 78:2330-2334.
  36. Day, L.E., Hirst, A.J., Lai, E.C., Mace, M.L. and Woo, S.L.C. 1981. 5' Domain and nucleotide sequence of an adult chicken o-globin gene. Biochemistry 20:2091-2098.
  37. Knoll, B., Woo, S.L.C. and O'Malley, B.W. 1981. Identification and sequence analysis of the 5' domain of the X and Y pseudo-ovalbumin genes. J. Biol. Chem. 256:7949-7953.
  38. Woo, S.L.C., Dugaiczyk, A., Catterall, J.F., Brownless, G.G. and O'Malley, B.W. 1981. Nucleotide sequence of the complete chick ovalbumin gene and its biological significance. Biochemistry 20:6437-6446.
  39. Chandra, T., Bullock, D. and Woo, S.L.C., 1981. Hormonally regulated mammalian gene expression: Steady state level and nucleotide sequence of rabbit uterglobin mRNA. DNA 1:19-26.
  40. Snead, R., Day, L., Chandra, T., Mace, M., Bullock, D. and Woo, S.L.C. 1981. Mosaic structure and mRNA precursors of uteroglobin, a hormone regulated mammalian gene. J. Biol. Chem. 256:11911-11916.
  41. Chandra, T., Kurachi, K, Davie, E.W. and Woo, S.L.C. 1981. Induction of alpha-l-antitrypsin mRNA and cloning of its cDNA gene. Biochem. Biophys. Res. Commun. 103:751-758.
  42. Kurachi, K, Friezner Degen, S.J., Chandra, T., Woo, S.L.C. and Davie, E.W. 1981. Cloning and sequence of cDNA coding for al-antitrypsin. Proc. Natl. Acad. Sci. U.S.A. 78:6826-6830.
  43. Lawson, G.M., Knoll, B.J., March, C.J., Woo, S.L.C., Tsai, M.J and O'Malley, B.W. 1982. Definition of 5' and 3' structural boundaries of the chromatin containing the ovalbumin gene family. J. Biol. Chem. 257:1501-1507.
  44. Leicht, M., Long, G.L., Chandra, T., Kurachi, K. Kidd, V.J., Mace, M.L., Davie, E.W. and Woo, S.L.C., 1982. Sequence homology and structural comparison between the chromosomal human al-antitrypsin and chicken ovalbumin genes. Nature 297:655-659.
  45. Zarucki-Schulz, T., Tsai, S., Itakura, K., Soberon, X., Wallace, R.B., Tsai, M.J., Woo, S.L.C. and O'Malley, B.W. 1982. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on transcription in vitro. J. Biol. Chem. 257:11070-11077.
  46. Lai, E.C., Woo, S.L.C. and O'Malley, B.W. 1982. "Eterogenous transcription initiation in the chicken ovalbumin gene. Nucl. Acids Res. 10:5553-5667.
  47. Kumar, N., Chandra, T., Woo, S.L.C. and Bullock, D. 1982. Hormonal regulation of uteroglobin messenger RNA. Endocrinology 111:1115-1120.
  48. Robson, K., Chandra, T., MacGillivray, R. and Woo, S.L.C. 1982. Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA. Proc. Natl. Acad. Sci. 79:4701-4705.
  49. Stackhouse, R., Chandra, T., Robson, K.J.H. and Woo, S.L.C. 1983. Purification of antithrombin mRNA and cloning of its cDNA. J. Biol. Chem. 258:703-706.
  50. Shen, X.Z., Tsai, M.J., Bullock, D.W. and Woo, S.L.C. 1983. Hormonal regulation of uteroglobin gene expression. Endocrinology 112:871-876.
  51. Chandra, T., Stackhouse, R. and Woo, S.L.C. 1983. Complete nucleotide sequence of a human antithrombin III cDNA clone. Proc. Natl. Acad. Sci. 80:1845-1848.
  52. Legace, L., Chandra, T., Woo, S.L.C. and Means, A.R., 1983. Identification of multiple species of calmoderation messenger RNA using a full length complementary DNA. J. Biol. Chem. 258:1684-1688.
  53. Lai, E.C., Kao, F.T., Law, M.L. and Woo, S.L.C. 1983. Assignment of the al-antitrypsin and a sequence related gene to human chromosome 14. Am. J. Human Genetics. 35:385-392.
  54. Kidd, V.J., Wallace, R.B., Tan, Z-K, Itakura, K. and Woo, S.L.C. 1983. al-antitrypsin deficiency detection by direct analysis of the mutation site in the gene. Nature 304:230-234.
  55. Snead, M.L., David, M.Z., Chandra, T., Robson, K.J.H., Woo, S.L.C. and Slavkin, H.C. 1983. Construction and identification of mouse amelogenin cDNA clones. Proc. Natl. Acad. Sci. 80:7524-7258.
  56. Chandra, T., Stackhouse, R., Robson, K.J.H. and Woo, S.L.C. 1983. Sequence homology between human al-antichymotrypsin, al-antitrypsin, and antithrombin III. Biochemistry 22:5055-5061.
  57. Woo, S.L.C., Lidsky, A., Chandra, T., Guttler, F. and Robson, K 1983. Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria. Nature 306:151-155.
  58. Kidd, J., Wallace, R.B., Tan, Z.K, Itakura, K., Golbus, M. and Woo, S.L.C. 1984. Prenatal diagnosis of al-antitrypsin deficiency by oligonucleotide mapping of the gene. New Engl. J. Med. 310:639-642.
  59. Lidsky, A., Robson, K., Chandra, T., Barker, P., Ruddle, F. and Woo, S.L.C. 1984. The PKU locus in man on chromosome 12. Am. J. Human Genetics 36:527-533.
  60. Woo, S.L.C., Lidsky, A., Chandra, T., Guttler, F. and Robson, K. 1984. Prenatal diagnosis of classical phenylketonuria by gene mapping. JAMA 251:1998-2002.
  61. Kao, F.T., Morse, H.G., Law, M.L., Lidsky, A., Chandra, T. and Woo, S.L.C., 1984. Genetic mapping of the structural gene for antithrombin III to human chromosome 1. Hum. Genet. 67:34-36.
  62. Long, G.L., Chandra, T., Woo, S.L.C., Davie, E.W., and Kurachi, K., 1984. Complete sequence of the cDNA for human al-antitrypsin and the gene for the S variant. Biochemistry 23:4828-4838.
  63. Robson, K.J.H., Beattie, W., James, R.J., Cotton, R.C.H., Morgan, F.J., and Woo, S.L.C. 1984. Sequence comparison of rat liver phenylalanine hydroxylase and its cDNA clones. Biochemistry 23:5671-5675.
  64. Woo, S.L.C., 1984. Prenatal diagnosis and carrier detection of classic phenylketonuria by gene analysis. Pediatrics 74:412-423.
  65. Kidd, V.J. and Woo, S.L.C., 1984. Recombinant DNA probes used to detect genetic disorders of the liver. Hepatology 4:731-736.
  66. DiLella, A.G., Ledley, F.D., Rey, F., Munich, A. and Woo, S.L.C., 1985. Detection of Phenylalanine hydroxylase messenger RNA in PKU liver biopsies. Lancet 19:160-161.
  67. Kwok, S.C.M., Ledley, F.D., DiLella, A.G., Robson, K.J.H. and Woo, S.L.C., 1985. Nucleotide sequence of a full-length cDNA clone and amino acid sequence of human phenylalanine hydroxylase. Biochemistry 24:556-561.
  68. Lidsky, A.S., Guttler, F. and Woo, S.L.C., 1985. Prenatal diagnosis of classical phenylketonuria by DNA analysis. Lancet 1:549-551.
  69. Ledley, F.D., Grenett, H.E., DiLella, A.G., Kwok, S.C.M. and Woo, S.L.C., 1985. Gene transfer and expression of human phenylalanine hydroxylase. Science 228:77-79.
  70. Snead, M.L., Lau, E.C., Zeichner-David, M., Fincharn, A.G., Woo, S.L.C. and Slavkin, H.C. 1985. DNA sequence for cloned cDNA for murine amelogenin reveal the amino acid sequence for enamel-specific protein. Biochem. Biophys. Res. Commun. 129:812-818.
  71. Cox, D.W., Woo, S.L.C. and Mansfield, T. 1985. DNA restriction fragments associated with al-antitrypsin indicate a common origin for deficiency alleles, PiZ. Nature 316:79-81.
  72. Ledley, F.D., DiLella, A.G., Kwok, S.C.M. and Woo, S.L.C. 1985. Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains. Biochemistry 24:3389-3394.
  73. Lidsky, A., Ledley, F.D., DiLella, A.G., Kwok, S.C.M., Daiger, S.P., Robson, K.J.H. and Woo, S.L.C., 1985. Molecular genetics of phenylketonuria: Extensive restriction site polymorphisms in the human phenylalanine hydroxylase locus. Am. J. Hum. Genet. 37:619-634.
  74. Lidsky, A.S., Law, M.L., Morse, H.G., Kao, F.T., Raben, M., Ruddle, F.H. and Woo, S.L.C., 1985. Regional mapping of the human phenylalanine hydroxylase gene and the PKU locus on chromosome 12. Proc. Nat. Acad. Sci.:6221-6225.
  75. Schroeder, W.T., Miller, M.F., Woo, S.L.C. and Saunders, G.F., 1985. Chromosomal Localization of the Human Alpha-1-Antitrypsin Gene (PI) to 1431-32. Am J. Hum Genet 37:868-872.
  76. Ledley, F.D., Grenett, H.E., McGinnis-Shelnutt, M. and Woo, S.L.C., 1986. Retroviral Mediated Gene Transfer of Human Phenylalanine Hydroxylase Into NIH3T3 And Hepatoma Cells. Proc. Natl. Acad. Sci.. U.S.A. 83:409-413.
  77. DiLella, A.G., Kwok, S.C.M., Ledley, F.D., Marvit, J. and Woo, S.L.C., 1986. Molecular Structure and Polymorphic Map of the Human Phenylalanine Hydroxylase Gene. Biochemistry 25:743-749.
  78. Daiger, S.P., Lidsky, A.S., Chakraborty, R., Koch, R., Guttler, F. and Woo, S.L.C., 1986. Effective Use of Polymorphic DNA Haplotypes at the Phenylalanine Hydroxylase Locus in Prenatal Diagnosis of Phenylketonuria. Lancet 1:229-231.
  79. Rabin, M., Watson, M., Kidd, V., Woo, S.L.C., Breg, W.R. and Ruddle, F.H., 1986. Regional Location of al-Antichymotlypsin and al-Antitrypsin Genes on Human Chromosome 14. Somatic Cell and Molecular Genetics 12:209-214.
  80. Ledley, F.D., Levy, H.L. and Woo, S.L.C., 1986. Molecular Analysis of the Inheritance of Phenylketonuria and Mild Hyperphenylalaninemia in Families with Both Diseases. New England Journal of Medicine 314:1276-1280.
  81. Muensche, H., Gaidulis, L., Kueppers, F., So, S.Y., Escano, G., Kidd, V.J. and Woo, S.L.C., 1986. Complete absence of serum al-antitrypsin in conjunction with an apparently normal gene structure. Am. J. Human Genet. 38:898-907.
  82. DiLella, A.G., Marvit, J. Lidsky, A.S., Guttler, F. and Woo, S.L.C., 1986. Tight linkage between a splicing mutation and a DNA haplotype in phenylketonuria. Nature 322:799-803.
  83. Mattera, R., Codina, J., Crozat, A., Kidd, V., Woo, S.L.C. and Birnbaumer, L., 1986. Identification by molecular cloning of two forms of the a-subunit of the human liver stimulatory (Gs) regulatory component of adenylyl cyclase. FEBS 206:36-42.
  84. Codina, J., Stengel, D., Woo, S.L.C. and Birnbaumer, L., 1986. o-Subunits of the human liver Gs/Gj signal-transducing proteins and those of bovine retinal rod cell transducin are identical. FEBS 207:187-192.
  85. Woo, S.L.C., DiLella, A.G., Marvit, J. and Ledley, F.D. 1986. Molecular Basis of Phenylketonuria and Potential Somatic Gene Therapy. Cold Spring Harbor Symposium in Quantitative Biology. In : Symposia on Quantitative Biology, vol. LI, pp.395-401.
  86. Ledley, F.D. and Woo, S.L.C., 1987. P-Chlorophenylalanine Does Not Inhibit Production of Recombinant Human Phenylalanine Hydroxylase in NIH3T3 Cells or E. coli. Biochem. Biophys. Res. Comm. 142:302-308.
  87. Sifers, R.N., Carlson, J., Clift, S.M., DeMayo, F.J., Bullock, D.W. and Woo, S.L.C., 1987. Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice. N.A.R. 15:1459-1475.
  88. Guttler, F., Lidsky, A.S., Ledley, F.D., DiLella, A.G., Sullivan, S.E., Woo, S.L.C., 1987. Correlation between polymorphic DNA haplotypes at the phenylalanine hydroxylase locus and the clinical phenotypes of phenylketonuria. J. Pediat. 110:68-71.
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  181. Kolodka, T., Finegold, M., and Woo, S.L.C. 1993. Hepatic Gene Therapy: Efficient retroviral mediated gene transfer into rat hepatocytes in vivo. Som. Cell & Mol. Gen. 19:5:491-497.
  182. Kleiman, S., Li, J., Schwartz, G., Eisensmith, R., Woo, S.L.C., and Shiloh, Y. 1993. Inactivation of Phenylalanine hydroxylase by a missense mutation, R270S, in a Palestinian kinship with PKU. Hum.Mol. Gen. 2:605-606.
  183. Svensson, E., Wang, Y., Eisensmith, R., Hagenfeldt, L., and Woo, S.L.C. 1993. Three Polymorphisms but no disease-causing mutations in the proximal part of the promoter of the phenylalanine hydroxylase gene. Eur. J. Hum.Genet. 1:306-313.
  184. Wang, Y., Hahn, T., Tsai, S., and Woo, S.L.C. 1994. Functional Characterization of a Unique Liver Gene Promoter. J. Biol. Chem. 269:9137-9146.
  185. Kay, M., Landen, C., Rothenberg, S., Taylor, L., Leland, F., Wiehle, S., Fang, B., Bellinger, D., Finegold, M., Thompson, A., Read, M., Brinkhous, K., and Woo, S.L.C. 1994. In Vivo Gene Therapy: Complete Albeit Transient Correction of Factor IX Deficiency in Hemophilia B. Dogs. Proc. Natl Acad. Sci. 91:2353-2357.
  186. Chen, S.H., Shine, D., Goodman, C., Grossman, R., and Woo, S.L.C. 1994. Gene Therapy for Brain Tumors: Regression of Experimental Gliomas By Adenovirus-Mediated Gene Transfer In Vivo. Proc. Nat. Acad. Sci. 91:3054-3057.
  187. Kleiman, S., Avigad, S., Vanagaite, L., Shmuelevitz, A., David, M., Eisensmith, R., Brand, N., Schwartz, G., Rey, F., Munnich, A., Woo, S.L.C., and Shiloh, Y. 1994. Origins of Hyperphenylalaninemia in Israel. Eur.J.Hum.Genet. 2:24-34.
  188. Gottschalk, S., Cristiano, R.J., Smith, L.C., and Woo, S.L.C. 1994. Folate Receptor Mediated DNA Delivery into Tumor Cells: Potosomal Disruption Results in Enhanced Gene Expression. Gene Therapy 1:185-191.
  189. Fang, B., Eisensmith, R.C., Li, X.H.C., Shedlovsky, A., Dove, W., and Woo, S.L.C. 1994. Gene Therapy for Phenylketonuria: Phenotypic correction of PKU in a mouse model by adenovirus-mediated hepatic gene transfer. Gene Therapy 1:247-254.
  190. Li, J., Eisensmith, R., Wang, T., Lo, W.H.Y., Huang, S.Z., Zeng, Y.T., Yuan, L.F., Liu, S.R., and Woo, S.L.C. 1994. Phenylketonuria in China: Characterization of Three Novel Mutations in the Human Phenylalanine Hydroxylase Gene. Human Mutation 3:312-314.
  191. Cruet-Perez, M., Trask, T., Chen, S.H., Goodman, C., Woo, S.L.C., Grossman, R., Shine, D. 1994. Adenovirus Mediated Gene Therapy of Experimental Gliomas. J. Neurosci. Res. 39:506-511.
  192. Li, J., Fang, B., Eisensmith, R., Li, X.H., Nasonkin, I., Lee, Y.C., Mims, M., Hughes, A., Montgomery, C., Roberts, J., Parker, T., Levine, D., and Woo, S.L.C. 1994. In Vivo Gene Therapy for Hyperlipidemia: Phenotypic Correction in Watanabe Rabbits by Hepatic Delivery of the Rabbit LDL Receptor Gene. J. Clin. Invest. 95:768-773.
  193. Eisensmith, R.C., Goltsov, A., and Woo, S.L.C. 1994. A Simple, Rapid, and Highly Informative PCR-based Procedure for Prenatal Diagnosis and Carrier Screening of Phenylketonuria. Prenatal Diagnosis 14:1113-1118.
  194. O'Malley, Jr., B.W., Chen, S.H., Schwartz, M., and Woo, S.L.C. 1995. Adenovirus-Mediated Gene Therapy for Human Head and Neck Squamous Cell Cancer in a Nude Mouse Model. Cancer Research 55:1080-1085.
  195. Bonnekoh, B., Greenhalgh, D., Bundman, D., Eckhardt, J., Longley, M.A., Chen, S.H., Woo, S.L.C. and Roop, D. 1995. Inhibition of Melanoma Growth by Adenoviral-Mediated HSV Thymidine Kinase Gene Transfer In Vivo. J. Invest. Dermat. 104:313-317.
  196. Kay, M.A., Graham, F., Leland, F. and Woo, S.L.C. 1995. Therapeutic Serum Concentrations of Human Alpha-1-Antitrypsin After Adenoviral-Mediated Gene Transfer Into Mouse Hepatocytes. Hepatology 21:815-819.
  197. Chen, S.H., Chen, X.H.L., Wang, Y., Kosai, K., Finegold, M., Rich, S., and Woo, S.L.C . 1995. Combination Gene Therapy for Liver Metastasis of Colon Carcinoma In Vivo. Proc. Natl. Acad. Sci. 92:2577-2581.
  198. Eisensmith, R.C., Goltsov, A., O'Neill, C., Tyfield, L., Schwartz, E., Kuzmin, A., Baranovskaya, S., Tsukerman, G., Treacy, E., Scriver, C., Guttler, F., Guldberg, P., Eiken, H., Apold, J., Svensson, E., Naughten, E., Cahalane, S., Croke, D., Cockburn, F., and Woo, S.L.C. 1995. Recurrence of the R408W mutation in the PAH locus in Europeans. Am. J. Hum. Genet. 56:278-286.
  199. 201. Kolodka, T.M., Finegold, M., Moss, L., and Woo, S.L.C. 1995. Gene Therapy for Diabetes Mellitus in Rats by Hepatic Expression of Insulin. Proc. Natl. Acad. Sci. 92:3293-3297.
  200. Fang, B., Eisensmith, R.C., Wang, H., Kay, M.A., Cross, R.E., Landen, C.N., Gordon, G., Bellinger, D.A., Read, M.S., Hu, P.C., Brinkhous, K.M., and Woo, S.L.C. 1995. Gene Therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Human Gene Therapy 6:1039-1044.
  201. Gottschalk, S., Tweten, R., Smith, L.C., and Woo, S.L.C. 1995. Efficient Gene Delivery Expression in Mammalian Cells Using DNA Coupled with Perfringolysin O. Gene Therapy 2:498-503.
  202. Colak, A., Goodman, J.C., Chen, S.H., Woo, S.L.C., Grossman, R.G., and Shine, H.D. 1995. Adenovirus-Mediated Gene Therapy in an Experimental Model of Breast Cancer Metastatic to the Brain. Human Gene Therapy 6:1317-1322.
  203. Kuzmin, A., Eisensmith, R.C., Sergeeva, N., Schwartz, E., and Woo, S.L.C. 1995. Complete Spectrum of PAH Mutations in Tataria: Eur. J. Hum. Genet. 3:246-255.
  204. Colak, A., Goodman, J.C., Chen, S.H., Woo, S.L.C., Grossman, R.G., and Shine, H.D. 1995. Adenovirus-Mediated Gene Therapy for Experimental Spinal Cord Tumors: Tumoricidal Efficacy and Functional Outcome. Brain Research 691:76-82.
  205. B. Fang, H. Wang, G. Gordon, D.A. Bellinger, M.S. Read, K.M. Brinkhous, S. L.C. Woo and R.C. Eisensmith.1996 Lack of Persistence of E1 - Recombinant Adenoviral Vectors Containing a Temperature-Sensitive E2A Mutuation in Immunocompetent Mice and Hempohilia B Dogs. Gene Therapy 3: 217-222.
  206. Eisensmith, R.C., Martinez, D.R., Kuzmin, A.I., Goltsov, A.A., Brown, A., Singh, R., Elsas, L., and Woo, S.L.C. 1996 Molecular Basis of Phenylketonuria and a Correlation between Genotype and Phenotype in a Heterogeneous Southeastern U.S. Population. Pediatrics 97:512-516.
  207. Goodman, J.C., Trask, T.W., Chen, S.H., Woo, S.L.C., Grossman, R.G., Carey, K.D., Hubbard, G.B., Carrier, D.A., Rajagopalan, S., Aguilar-Cordova, E., Shine, H.D. 1996. Adenoviral-Mediated Thymidine Kinase Gene Transfer Into the Primate Brain Followed by Systemic Ganciclovir: Pathologic, Radiologic and Molecular Studies. Human Gene Therapy 7:1241-1250.
  208. Eastham, J., Chen, S.H., Sehgal, I., Timme, T., Hall, S., Woo, S.L.C., Thompson, T. 1996. Prostate Cancer Gene Therapy: Herpes Simplex Virus Thymidine Kinase Gene Transduction Followed by Ganciclovir in Mouse and Human Prostate Models. Human Gene Therapy 7:515-523.
  209. Gottschalk, S., Sparrow, J.T., Hauer, J., Leland, F.E., Woo, S.L.C., and Louis C. Smith. 1996. A Novel DNA/Peptide Complex for Efficient Gene Transfer and Expression in Mammalian Cells. Gene Therapy 3:448-457.
  210. Tong, X.-W., Block, A., Chen, S-H., Contant, C.F., Agoulnik, I., Blankenburg, K., Kaufman, R.H., Woo, S.L.C., and Kieback, D.G. 1996 Adenovirus-Mediated Thymidine Kinase Gene Therapy of Human Epithelial Ovarian Cancer followed by Exposure to Ganciclovir. Gynecological Oncology 61:175-178.
  211. Yee, D., McGuire, S.E., Brunner, N., Kozelsky, T.W., Allerk, D.C., Chen, S-H. and Woo, S.L.C.1996. Adenovirus-Mediated Gene Transfer of HSV-tk an Asuites Model of Human Breast Cancer - Human Gene Therapy 7:1251-1257.
  212. O'Malley, Jr., B., Cope, K.A., Chen, S-H., Li, D., Schwartz, M.R. and Woo, S.L.C. 1996. Combination Gene Therapy for Oral Cancer in a Murine Model Cancer Research 56:1737-1741.
  213. Santos, M., Kuzmin, A., Eisensmith, R., Goltsov, A., Woo, S.L.C., Barrantes R, de Cespedes, C. 1996. Phenylketonuria in Costa Rica: Spectrum of PAH Mutations and their Associations with Highly Polymorphic Haplotypes. Human Heredity 46:128-131.
  214. Huang, H. Chen, S.H., Kosai, K., Finegold, M.J., and Woo, S.L.C. 1996. Gene Therapy for Hepatocellular Carcinoma: Long-term Remission of Primary and Metastatic Intraperitoneal Tumors in Mice by IL-2 Gene Therapy In Vivo. Gene Therapy
  215. Bowles, N.E., Eisensmith, R.C., Mohuiddin, R., Pyron, M., and Woo, S.L.C. 1996. A Simple Method for the Concentration and Purification of Recombinant Retrovirus for Efficient Cellular Transduction In Vitro and In Vivo. Human Gene Therapy 7:1735-1742.
  216. Tong, X.-W., Block, A., Chen, S-H., Kieback, D.G. and Woo, S.L.C. 1996. Adenovirus-Mediated Thymidine Kinase Gene Therapy of Human Epithelial Ovarian Cancer followed by Exposure to Ganciclovir. Anti-Cancer Research 16:1611-1618.
  217. Bonnekoh, G., Greenhalgh, D.A., Bundman, D.S., Kosai, K., Chen, S-H., Finegold, M.J., Krieg, T., Woo, S.L.C., and Roop, D.R. 1996. Adenoviral-Mediated HSV thymidine Kinase Gene Transfer invivo for Treatment of Experimental Human Melanoma. J. of Invest. Dermatol. 106:1163-1167.
  218. Chen, S.H., Kosai, H.I., Xu, B., Pham-Nguyen, K., Contant,C., Finegold, M.J., and Woo, S.L.C. 1996. Combination Suicide and Cytokine Gene Therapy for Hepatic Metastases of Colon Carcinoma; Sustained Antitumor Immunity Prolongs Animal Survival. Cancer Research 56:3758-3762.
  219. Kwong, Y.L., Chen, S.H., Kosia, K. Finegold, M. J., Woo, S. L.C. 1996. Adenoviral Mediated Suicide Gene Therapy for Hepatic Metastases of Breast Cancer. Cancer Gene Therapy 7:1251-1257.
  220. Guo, Z.H., Woo, S.L.C. Wang, Eisensmith, R.C. and Woo, S.L.C. 1996. Evaluation of Promoter Strength for Hepatic Gene Expression in Vivo Following Adenovirus-Mediated Gene Transfer. Gene Therapy 9:802-810.
  221. Muzzin, P. Eisensmith, R.C., Copeland, K.C. and Woo, S. L. C. 1996. Correction of Obesity and Diabetes in Genetically Obese Mice by Leptin Gene Therapy. Proc. Nat'l Acad. Sci. 93:14804-14808.
  222. Hahn, T., Copeland, K.C. and Woo, S.L.C. 1996. Phenotypic Correction of Dwarfism by Constitutive Expression of Growth Hormone Endocrinology 137:4988-4993.
  223. Caruso, M., Pham-Nguyen, K., Kwong, Y-L., Xu, B., Kosai, K-I., Finegold, M., Woo, S.L.C. and Chen, S-H. 1996. Adenovirus-Mediated Interleukin-12 Gene Therapy for Metastatic Colon Carcinoma. Proc. Nat'l Acad. Sci. 93:11302-11306.
  224. Tong, X.W., Block A., Chen, S.H., Contant, C.F., Agoulnik, I., Blankenburg, K., Kaufmen, R.H., Woo, S.L.C., and Kieback, D.G. 1996. In Vivo Gene Therapy of Ovarian Cancer by Adenovirus-Mediated Thymidine Kinase Gene Transolution and Ganciclovir Administration Gynecol. Oncol. 61:175-179.
  225. Kwong, Y.L., Chen, S.H., Kosai, K., Finegold, M.J., and Woo, S.L.C. 1997. Combination Suicide and Cytokine Gene Therapy for Hepatic Metastases of Lung Cancer. Chest 112:1332-1337.
  226. Block, A., Chen, S.H., Kosai, K.I., Finegold, M.J., and Woo, S.L.C. 1997. Adenovirus Mediated Suicide Gene Therapy of Pancreatic Cancer. Pancreas 15:25-34.
  227. Muzzin, P., Eisensmith, R.C., Copeland, K.C. and woo, S.L.C. 1997. Hepatic Insulin Gene Expression As Treatment for Type I Diabetes Mellitus In Rats. Molec. Endocrin. 11:833-837.
  228. Hall, S.J., Mutchnik, S.E., Chen, S-H., Woo, S.L.C., Thomposon, T.C. 1997. Adenoviral mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer. Int. J. Can. 70:183-187.
  229. Sutton, M.A., Berkman, S.A., Chen, S-H., Block, A., Dang, T.D., Kattan, M.W., Wheller, T.M., Rowley, D.R., Woo, S.L.C. and Lerner, S.P. 1997. Adenovirus-mediated suicide gene therapy for experimental bladder cancer. Urology 49:173-180.
  230. O’Malley, B.W. Jr., Sewell, D.A., Li, D. Kosai K., Chen, S-H., Woo, S.L.C. and Duan, L. 1997. The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer. Mol. Endocrinol 11:667-673.
  231. Shine, H.D., Wyde, P.R., Aguilar-Cordova, E., Chen, S-H., Woo, S.L.C., Grossman, R.G., Goodman, J.C., 1997. Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat) Gene Therapy 4:275-279.
  232. Rojas-Martines, A., Wyde, P.R., Montgomery, C.A., Chen, S-H., Woo, S.L.C., Aguilar-Cordova, E. 1998. Distribution, persistency, toxicity, and lack of replication of an E1A-recombinant adenoviral vector after intracardiac delivery in the cotton rat. Cancer Gene Therapy 5:365-370.
  233. Bonnekoh, B., Greenhalgh, D.A., Chen, S-H., Block, A., Rich, S.S., Krieg, T., Woo, S.L.C., Roop, D.R. 1998. Ex Vivo and In Vivo Adenovirus-Mediated Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defence in the B16 Melanoma Model. J. Invest. Dermatol. 6:867-71
  234. Kosai, K-I., Finegold, M.J., Thi-Huynh, B-T., Tewson, M., Ou, C-N., Bowles, N., Woo, S.L.C., Schwall, R.H., Darlington, G.J. 1998. Retrovirus-mediated in vivo Gene Transfer in the Replicating Liver Using Recombinant Hepatocyte Growth Factor Without Liver Injury or Partial Hepatectomy. Human Gene Therapy 9:1293-1301.
  235. Timme, T.L., Hall, S.J., Barrios, R., Woo, S.L.C., Aguilar-Cordova, E., and Thompson, T.C. 1998. Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene followed by ganciclovir therapy in mice. Cancer Gene Therapy 5:74-82.
  236. Effat L, Kuzmin A, Kasem N, Meguid NA, Kotb S, Eisensmith RC, Temtamy SA, Rushdi S, Woo S, El-Awady M. 1999. Haplotypes and Mutations at the PAH locus in Egyptian Familes with PKU. Eur J Hum Genet. 2:259-62.
  237. Qiao, J., Chen, S.H., Pham-Nguyen, K.B., Woo, S.L.C., 1999. Construction and Characterization of a Recombinant Adenoviral Vector Expressing Human Interleukin-12. Cancer Gene Therapy 6:373-379.
  238. Pham-Nguyen, K.B., Yang W., Saxena, R, Thung, S.N., Woo S.L.C., Chen, S-H. 1999. Role of NK and T Cells in IL-12 induced anti-tumor response against hepatic colon carcinoma. Int. J. Cancer 81:813-819.
  239. Waugh, J.M., Kattash, M., Li, J., Yuksel, E., Saxena, R., Thung, S.N., Shenaq, S.M., Woo, S.L.C. 1999. Local overexpression of thrombomodulin for in vivo prevention of arterial thrombosis in a rabbit model. Circulation Res. 84:84-92.
  240. Herman, J.R., Adler, H.L., Aguilar-Cordova, E., Rojas-Martinez, A., Woo, S.L.C., Timme, T.L., Wheeler, T.M., Thompson, T.C., Scardino, P.T. 1999. In Situ gene therapy for prostate cancer. Human Gene Therapy 7:1239-49.
  241. O’Malley, Jr., B.W., Li, D., Buckner, A., Duan, L., Woo, S.L.C., Pardoll, D.M. 1999. Limitations of Adenovirus-Mediated Interleukin-2 Gene Therapy for Oral Cancer. The Laryngoscope 3:389-95.
  242. Hall, S.J., Mutchnik, S.E., Yang, G., Timime, T.L., Nasu, Y., Bangma, C.H., Woo, S.L.C., Shaker, M. and Thompson, T. 1999. Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer. Cancer Gene Therapy 6:54-63.
  243. Waugh, J.M., Kattash, M., Li, J., Yukel, E., Kao, M.D., Lussier, M., Weinfeld, A.B., Saxena, R., Rabinovsky, E.D., Thung, S., Woo, S.L.C. and Shenaq, S.M. 1999. Gene Therapy to Promote Thromborasistance: Local Overexpression of Tissue Plasminogen Activator to Prevent Arterial Thrombosis in an in vivo Rabbit Model. Proc. Natl. Acad. Sci. 96:1065-1070.
  244. Tjuvajev, J.G., Chen S.H., Joshi, R., Balatoni, J., Ballon, D., Koutcher J., Finn, R., Woo, S.L.C., Blasberg, R.G. 1999. Imaging Adenoviral Mediated Herpes Virus Thymidine Kinase Gene Transfer and Expression In Vivo. Cancer Research 59:5186-5193.
  245. Herman, J.R., Adler, H.L. Aguilar-Cordova, E., Rojas-Martinez, A., Woo, S.L.C., Timme, T.L., Wheeler, T.M., Thompson, T.C., Scardino, P.T. 1999. In Situ Gene Therapy for Adenocarcinoma of the Prostate: a Phase I Clinical Trial. Human Gene Therapy 7:1239-1250.
  246. Divino, C., Chen, S.H., Yang W., Thung, S., Woo, SLC. 1999. Anti-tumor Immunity Induced by Interleukin-12 Gene Therapy in an Orthotopic Model of Breast Cancer is Mediated by Natural Killer Cells. Breast Cancer Research and Treatment 60:129-134.
  247. Enns, G.M., Martinez, D.R., Kuzmin, A.I., Koch, R., Wakeem, C.K., Woo, S.L.C., Eisensmith, R. C., and Packman, S. 1999. Molecular Correlations in Phenylketonuria: Mutation Patterns and Corresponding Biochemical and Clinical Phenotypes in a Heterogeneous California Population. Pediatric Research 46:594-602.
  248. Waugh, J.M., Li-Hawkins, J., Yuksel, E., Kuo, M.D., Cifra, P.N., Hilfiker, P.R., Geske, R., Chawla, M., Thomas, J., Shenaq, S.M., Dake, M.D., Woo, S.L.C. 2000. Thrombomodulin Overexpression to Limit Neointima Formation. Circulation 102:332-337.
  249. Trask, T.W., Trask, R.P., Aguilar-Cordova, E., Shine, H.D., Wyde, P.R., Goodman, J.C., Hamilton, W.J., Rojas-Martinez, A., Chen, S.H., Woo, S.L.C. and Grossman, R.G. 2000. Phase I Study of Adenoviral Delivery of the HSV-tk Gene and Ganciclovir Administration in Patients with Recurrent Malignant Brain Tumors. Molecular Therapy 1:195-202.
  250. Sauter, B.V., Martinet, O., Zhang, W-J, Mandeli, J., Woo, S.L.C. 2000. Adenovirus-mediated gene transfer of endostatin in vivo results in high level of transgene expression and inhibition of tumor growth and metastases. Proc. Natl. Acad. Sci. 97:4802-4807.
  251. Block A., Freund C., Chen S.H, Nguyen K.P., Finegold M., Windler, E., Woo, S.L.C. 2000. Gene therapy of metastatic colon carcinoma: Regression of multiple hepatic metastasis by adenoviral expression of bacterial cytosine deaminase. Cancer Gene Therapy 7:438-45.
  252. Chen, S.H., Pham-Nguyen, K.B., Martinet, O., Huang, Y., Yang, W., Thung, S.N., Chen L., Mittler, R., Woo, S. L. C. 2000. Rejection of Disseminated Metastases of Colon Carcinoma by Synergism of IL-12 Gene Therapy and 4-1BB Costimulation. Molecular Therapy 2:39-46.
  253. Chen, R., Meseck, M., McEvoy, RC, Woo, SLC. 2000. Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Gene Therapy 7:1802-1809.
  254. Dong, H., Morral, N., McEvoy, R., Meseck, M., Thung, S.N., Woo, S.L.C. 2001. Hepatic Insulin Expression Improves Glycemic Control in Type 1 Diabetic Rats. Diabetes Research and Clinical Practice 52:153-163.
  255. Sung, M.W., Yeh, HC, Thung, S. N., Schwartz, M.E., Mandeli, J. P., Chen, SH, Woo, S.L.C. 2001. Intratumoral Adenovirus-Mediated Suicide Gene Therapy for Hepatic Metastases from Colorectal Adenocarcinoma: Results of a Phase I Clinical Trial. 2001. Molecular Therapy 4:182-191.
  256. Waugh, J.M., Li-Hawkins, J., Yuksel, E., Cifra, P.N., Amabile, P.G., Hilfiker, P.R., Geske, R.S., Kuo, M.D., Thomas, J.W., Dake, M.D., Woo, S.L.C. 2001. Therapeutic Elastase Inhibition by Alpha-1-Antitrypsin Gene Transfer Limits Neointima Formation in Normal Rabbits. J. Vasc. Interv. Radiol. 12: 1203-1209.
  257. Chen, R., Meseck, M.L., Woo, S.L.C. 2001. Auto-regulated Hepatic Insulin Gene Expression in Type 1 Diabetic Rats. Molecular Therapy 3:584-590.
  258. Dong, H., Altomonte, J., Morral, N., Meseck, M., Thung, S.N., Woo, S.L.C. 2001. Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetes. Diabetes 152: 130-138.
  259. Qiao, J., Doubrovin, M., Sauter, B.V., Huang, Y., Balatoni, J., Akhurst, T., Blasberg, R.G., Tjuvajev, J.G., Chen, S.H., Woo, S.L.C. 2002. Tumor-Specfic Transcriptional Targeting of Suicide Gene Therapy. Gene Therapy 9:168-175.
  260. Sung, M.W., Chen, S.H., Thung, S.N., Zhang, D.Y., Woo, S.L.C. 2002. Intratumoral Delivery of Adenoviral Vector Expressing Murine Interleukin-12: A Dose Escalation Toxticity Study in Tumor-Bearing Mice. Human Gene Therapy 13: 731-743.
  261. Attur, M.G., Dave, M., Cipolletta, C., Meseck, M., Woo, S.L.C., Amin, A.R. 2002. Functional Genomic Analysis of Type II IL-1S Decoy Receptor: Potential for Gene Therapy in Human Arthritis and Inflammation. J. Immunol. 168: 2001-2010.
  262. Savontaus, M.J., Sauter, B.V, Huang, T., Woo, S.L.C. 2002. Transcriptional Targeting of Conditionally Replicating Adenovirus to Dividing endothelial Cells. Gene Therapy 9: 972-979.
  263. Morral, N., McEvoy, R., Dong, H.J., Meseck, M., Altomonte, J, Thung, S., Woo, S.L.C. 2002. Human Gene Therapy 13:1561-1570.
  264. Bhoumik, A., Huang, T.G., Ivanov, V., Gangi, L., Qiao, R.F., Woo, S.L.C., Chen, S.H. and Ronai, Z. 2002. ATF2-Derived Peptide Sensitizes Melanoma to Treatment and Inhibits in vivo Growth and Metastasis. J. Clin. Invest. 110:1-10.
  265. Huang, T., Savontaus, M., Shinosaki, K., Sauter, B. and Woo, S.L.C. 2003. Telomerase Dependent Oncolytic Adenovirus for Cancer Treatment. Gene Therapy 10:1241-1247.
  266. Ebert, O., Shinosaki, K., Huang, T., Savontaus, M., Garcia-Sastre, A. and Woo, S.L.C. 2003. Oncolytic Vesicular Stomatitis Virus for Treatment of Orthotopic Hepatocellular Carcinoma in Immune-competent Rats. Cancer Research 63: 3605-3611.
  267. Huang, T., Ebert, O., Shinosaki, K., Garcia Sastre, A. and Woo, S.L.C. 2003. Oncolysis of Hepatic Metastasis of Colorectal Cancer by Recombinant VSV in Immune-competent Mice. Molecular Therapy 8: 434-440.
  268. Shinosaki, K., Ebert, O., Kournioti, C., Tai, Y.S. and Woo, S. L.C. 2004. Oncolysis of Multi-focal Hepatocellular Carcinoma in the Rat Liver by Hepatic Artery Infusion of Vesicular Stomatitis Virus. Molecular Therapy 9: 368-376.
  269. Kubo, A., Shinosaki, K., Shannon, J.M., Kouskoff, V., Kennedy, M., Woo, S.L.C., Fehling, H.J. and Keller, G. 2004. Development of Definitive Endoderm from Embryonic Stem Cells in Culture. Develoment 161: 1651-1662.
  270. Ebert, O., Shinozaki, K. Kournioti, C., Park, M.S., García-Sastre, A. and Woo, S.L.C. 2004. Syncytia Induction Enhances the Oncollytic Potential of Vesicular Stomatitis Virus in Virotherapy for Cancer. 2004. Cancer Researsh 64: 3265-3270.
  271. Ebert, O., Harbaran, S., Shinozaki, K. and Woo, S.L.C. 2005. Systemic Therapy of Experimental Breast Cancer Metastases by Mutant Vesicular Stomatitis Virus in Immune-competent Mice. Cancer Gene Therapy 12:350-358.
  272. Shinosaki, K., Ebert, O. and Woo, S.L.C. 2005. Treatment of Colorectal Carcinoma Metastatic to the Rat Liver by Hepatic Artery Injection of Oncolytic Vesicular Stomatitis Virus. Int. J. Can. 114: 659-664.
  273. Shinosaki, K., Ebert, O. and Woo, S.L.C. 2005. Eradication of Advanced Hepatocellular Carcinoma in Rats via Repeated Hepatic Arterial Infusions of Recombinant VSV. Hepatology 41:196-203.
  274. Shinosaki, K., Ebert, O., Suriavinata, A., Thung, S. and Woo, S.L.C. 2005. Prophylactic IFN-alpha Treatment Increases the Therapeutic Index of Oncolytic VSV Virotherapy for Advanced Hepatocellular Carcinoma in Immune Competent Rats. J. Virology 79: 13705-13713.
  275. Xu, D., Sauter, B., Huang, T., Meseck, M., Woo, S.L.C. and Chen, S. 2005. The Systemic Administration of Ig-4-1BB Ligand in Combination with IL-12 Gene Transfer Eradicates Hepatic Colon Carcinoma. Gene Therapy 12: 1526-1533.
  276. Chen, L. and Woo, S.L.C. 2005. Complete and persistent Phenotypic Correction of PKU in Mice by site-specific Genome Integration of Murine PAH cDNA. Proc. Natl. Acad. Sci. 102:15581-15586.
  277. Shinozaki, K., Suominen, E., Carrick, F., Sauter, B., Kahari, V. Lieber, A., Woo, S.L.C. and Savontaus, M. 2006. Efficient Infection of Tumor Endothelial Cells by a Capsid-modified Adenovirus. Gene Therapy 13:52-59.

Symposium Proceedings, Book Chapters and Reviews
  1. Rosen, J.M., Woo, S.L.C., Means, A.R. and O'Malley, B.W. 1975. Purification and characterization of ovalbumin messenger RNA in hen oviduct In: Methods in Molecular Biology 8: Eukaryotes at the Subcellular Level (J.A. Last ed.) pp. 369-434.
  2. O'Malley, B.W., Woo, S.L.C., Harris, S.E., Rosen, J.M. and Means, A.R. 1975. Review: Steroid hormone regulation of specific messenger RNA and protein synthesis in eukaryotic cells. J. Cell Physiol. 85:343.
  3. Rosen, J.M., Chan, L., Harris, S.E., Woo, S.L.C., Means, A.R. and O'Malley, B.W. 1975. Hormonal regulation of RNA processing in the chick oviduct. In: Brookhaven Symposium Biology 26:3230.
  4. Woo, S.L.C. and O'Malley, B.W. 1976. Hormone inducible messenger RNA. Life Sciences O'Malley, B.W., Woo, S.L.C., Harris, S.E., Rosen, J.M., Comstock, J.P., Chan, L., Bordelon, C.B., Holder, J.W., Sperry, P. and Means, A.R. 1975. Steroid hormone action in animal cells. American Zoologist 5:215.
  5. Means, A.R., Woo, S.L.C., Bordelon, C., Comstock, J.P. and O'Malley, B.W. 1976. Hormone regulated synthesis of tissue specific proteins. In: Genetic Improvement of Seed Proteins. National Academy of Sciences, Washington, D.C., p. 288.
  6. O'Malley, B.W., Woo, S.L.C., Monahan, J.J., McReynolds, L., Harris, S.E., Tsai, M.J., Tsai, S.Y. and Means, A.R. 1976. The synthesis isolation, amplification and transcription of the ovalbumin gene. In: Molecular mechanisms in the control of gene expression. Proceedings of a 1976 ICN-UCLA Winter Conference on Molecular and Cellular Biology, eds. D.P. Nierlich, W.J. Rutter and C.F. Cox, p. 309.
  7. McReynolds, L.A., Monahan, J.J., Woo, S.L.C. and O'Malley, B.W. 1976. "Synthesis and isolation of a specific eukaryotic gene". In: International cell biology, 1976-1977, eds. Brinkley, B. and Porter, K. Rockefeller Press, New York, p. 168.
  8. Woo, S.L.C. and O'Malley, B.W. 1977."Purification and characterization of eukaryotic messenger RNAs and unique sequence eukaryotic genes". In: Receptors and hormone action, eds. O'Malley and Birnbaumer, L., Academic Press, N.Y., p. 267.
  9. O'Malley, B.W., Woo, S.L.C., Dugaiczyk, A., Lai, E.C., Roop, D., Tsai, S. and Tsai, M.1978. The organization and expression of the natural ovalbumin genes. In: Proceedings of the 10th Miami Winter Symposium.
  10. Dugaiczyk, A. and Woo, S.L.C. 1979. "Mapping and cloning of eukaryotic genes". In: Hormone action and molecular endocrinology workshop syllabus. eds. W.T. Schrader and B.W. O'Malley, p. 5-1.
  11. Dugaiczyk, A., Woo, S.L.C. and O'Malley, B.W. 1979. "Molecular structure of the ovalbumin gene and its genotypic alleles". In: Proceedings of the Stadler Symposium, University of Missouri, Columbia, Vol.11.
  12. O'Malley, B.W., Stein, J.P., Woo, S.L.C., Dugaiczyk, A., Catterall, J.F. and Lai, E.C. 1979. A comparison of the sequence organization of the chicken ovalbumin and ovomucoid genesn. In: ICN-UCLA Symposia, on eukaryotic gene regulation, pp. 381-299.
  13. O'Malley, B.W., Roop, D.R., Lai, E.C., Nordstrom, J.L., Catterall, J.F., Swaneck, G.E., Colbert, D., Tsai, M., Dugaiczyk, and Woo, S.L.C. 1979. "The ovalbumin gene:
  14. Organization, structure, transcription and regulation. In: Recent Progress in Hormone Research (Proc. of the 1978 Laurential Hormone Conference) (R. Greep, ed.) Academic Press, N.Y., Vol.35, pp. 1-46.
  15. Dugaiczyk, A., Woo, S.L.C. and O'Malley, B.W. 1979. "Genes in Pieces". In: Ontogeny of Receptors and Mode of Action of Reproductive Hormones (Hamilton, Clark and Saddler, eds) Raven Press, pp. 1-11.
  16. O'Malley, B.W., Stein, J.P., Woo, S.L.C., Catterall, J.F., Tsai, M. and Means, A.R. 1979. "The ovomucoid gene: Organization, structure and regulation. In: From Gene to Protein: Information Transfer in Normal and Abnormal Cells (Russell, T., Brew, R., Faber, A., Schultz, J. eds.) Academic Press, New York, pp. 15-53.
  17. Stein, J.P., Woo, S.L.C., Dugaiczyk, A., Tsai, S., Means, A.R. and O'Malley, B.W. 1979. "The structure and regulation of the natural chicken ovomucoid genen. In: Proceedings of the Meadowbrook Conference on the Molecular Mechanism of Steroid Hormones (A. Roy, ed) Springer-Verlag, New York, pp. 5-31.
  18. Woo, S.L.C. 1979. A sensitive and rapid method for recombinant phage screening. Methods in Enzymol. 68:389.
  19. Dugaiczyk, A., Woo, S.L.C., Tsai, M.J., Lai, E.C., Mace, M.L., Jr. and O'Malley, B.W. 1981. "Molecular organization and cloning of the ovalbumin gene". In: Genetic Engineering H.W. Boyer and S. Nicosia eds. Elsevier/ North-Holland Biomedical Press, pp. 99-107.
  20. O'Malley, B.W., Woo, S.L.C. and Tsai, M.J. 1981. "Structure and hormonal regulation of the ovalbumin gene cluster". In: Biological Cycles (R. Estabrook and P. Srere, eds.) Academic Press, New York, pp. 437-453.
  21. Woo, S.L.C., Tsai, J.J. and O'Malley, B.W. 1981. "Structure, expression and hormonal responsiveness of the authentic and pseudo-ovalbumin genes". In: Proceedings of the 2nd International Symposium on the role of RNA in Development and Reproduction (eds. M.C. Niu and H.H. Chuang), Science Press, Beijing, China, pp. 864-887.
  22. Davie, E.W., Kurachi, K, Chandra, T. and Woo, S.L.C. 1982. "The structure and cloning of the al-antitrypsin gene". In: Protein, Nucleic Acid and Enzyme ISSN. Vol. 27, pp. 1805-1809. Takkau, Japan.
  23. Woo, S.L.C., Chandra, T., Kidd, V.J., Kurachi, K, Long, G.L. and Davie, E.W., 1983. "The human l-antitrypsin gene: sequence homology and structural comparison with the chicken ovalbumin gene". In: Cetus-UCLA Symposia on Molecular and Cellular Biology-Gene Regulation. Vol. 26, pp. 55-64.
  24. Woo, S.L.C., Zu-Kun Tan, Wallace, R.B., Itakura, K. and Kidd, V.J. 1983. "a1-antitrypsin deficiency and pulmonary emphysema: identification of recessive homozygotes by direct analysis of the mutation site in the chromosomal genen. In: Recombinant DNA Application to Human Disease. Cold Spring Harbor Sym. Banbury Report, Vol. 14, pp. 105-112.
  25. Kidd, V.J. and Woo, S.L.C. 1984. "Molecular diagnosis of human genetic disorders". Modern Cell Biology, Alan-Liss Pub., ed. in chief, Satir, Vol. 3, p. 113.
  26. Snead, M.L., Zeichner-David, M., Woo, S.L.C. and Slavkin, H., 1984. "Construction and identification of molecular clones to mouse enamel proteins: The anatomy and physiology of the enamel genes". In: Proceedings of the IV International Symposium on Tooth Enamel, Japan; eds. R.W. Fearnhead and S. Suga, Elsevier Science Publishers B.V. pp. 172-176.
  27. Woo, S.L.C., Robson, K.J.H. and Guttler, F. 1984. The possibility for prenatal diagnosis of PKU bilinkage analysis based on phenylalanine hydroxylase locus specific DNA polymorphisms. Inter. Metab. Dis. 7 suppl. 2:139-140.
  28. Woo, S.L.C., Chandra, T., Stackhouse, R. and Kidd, V.J. 1985. "Molecular structure of plasma protein inhibitor genes in man. In: "Molecular Architecture of Proteins and Enzyme" (eds. R.A. Bradshaw and J. Tang). Academic Press, N.Y. pp. 229-257.
  29. Woo, S.L.C., Guttler, F., Ledley, F.D., Lidsky, S., Kwok, S.C.M., DiLella, A.G. and Robson, K.J.H. 1985. "The Human Phenylalanine Hydroxylase Genen, In: Vol. 177 "Medical Genetics Past: Present, Future" (ed. Kare Berg). Alan R. Liss, Inc., New York pp. 123-138.
  30. Woo, S.L.C. "Molecular genetics of hereditary disorders in man. 1985. In: 'The Third Seminar on Recombinant DNA Technology in Medical Research", Oiso, Japan pp. 23-40.
  31. DiLella, A.G. and Woo, S.L.C. "Cosmid cloning of genomic DNA". 1985. Focus 7 No. 2.
  32. DiLella, A.G., Ledley, F.D. and Woo, S.L.C. 1985. "Prenatal diagnosis and carrier detection of phenylketonuria by gene mapping". In: Biotechnology in Diagnostics, (eds. H. Koprowski, S. Ferrone and A. Albertini) Elsevier Science Publishers pp. 295-307.
  33. Guttler, F., Lidsky, A.S. and Woo, S.L.C., 1985. "Molecular Genetics of PKU: Prenatal Diagnosis and Carrier Detection by Gene Analysis". In: Inherited Diseases of Amino Acid Metabolism. (eds. H. Bickel and U. Wachtel), International Symposium in Heidelberg, Georg Thieme Verlag, Inc. Publishers pp. 18-19.
  34. Ledley, F.D. and Woo, S.L.C., 1985. "Molecular Genetics of PKU: Prenatal Diagnosis and Carrier Detection by Gene Analysis". In: Inherited Diseases of Amino Acid Metabolism". (eds. H. Bickel and U. Wachtel), International Symposium in Heidelberg, Georg Thieme Verlag, Inc. Publishers pp. 37-39.
  35. Ledley, F.D., DiLella, A.G. and Woo, S.L.C., 1985. "Molecular biology of phenylalanine hydroxylase and phenylketonuria". Trends in Genetics, 1:309-313.
  36. DiLella, A.G., Ledley, F.D. and Woo, S.L.C. 1985. "Prenatal Diagnosis and Carrier Detection of Phenylketonuria by Gene Mapping". In: Biotechnology in Diagnostics, Rome, Italy; eds. H. Koprowski, S. Ferrone, and A. Albertini, Elsevier Science Publishers. Vol. 21, pp. 295-307.
  37. Kidd, V.J. and Woo, S.L.C.. 1986. "Molecular analysis of the serine protease inhibitor gene family". In: Protease Inhibitors (eds. A. Barrett and G. Savesen) Elsevier, Amsterdam, pp. 421-440.
  38. Woo, S.L.C. 1986. "Recombinant DNA approaches to human genetic disorders", In: Genes and Disease: Proceedings of the First Sino-American Human Genetics Workshop (eds. Wu, M. and Nebert, D.W.), Science Press, Beijing, pp. 4-22.
  39. Ledley, F.D., DiLella, A.G. and Woo, S.L.C., 1986. "Molecular Biology of Phenylalanine Hydroxylase and Phenylketonuria". In: Tsukata, Yl, (ed.) The Ninth International Symposium on Brain Sciences. Molecular Genetics in Developmental Neurobiology. Japan Scientific Societies Press (JSSP), Tokyo, Japan. pp. 201-214.
  40. Ledley, F.D. and Woo, S.L.C., 1986. "Molecular Basis of Alpha-1-Antitrypsin Deficiency and Its Potential Therapy by Gene Transfer". In: J. Inher. Metab. Dis., (suppl 1): pp. 85-91.
  41. Guttler, F. and Woo, S.L.C, 1986. "Molecular Genetics of PKU". In: J. Inher. Metab. Dis., (suppl 1): pp. 58-68.
  42. Woo, S.L.C., 1986. "Prenatal Diagnosis and Carrier Detection of Classical Phenylketonuria. In: Perinatal Genetics; Diagnosis and Treatment (eds. Porter, I.H., Hatcher, N.H. and Willey, A M.), Fifteenth Annual Birth Defects Institute Symposium, New York, Academic Press, Inc. pp. 79-94.
  43. DiLella, A.G. and Woo, S.L.C., 1987. "Cloning Large Segments of Genomic DNA Using Cosmid Vectors". In: Methods in Enzymology, (eds. Berger, S.L. and Kimmel, AR.), vol 152, pp. 199-212.
  44. DiLella, A.G. and Woo, S.L.C., 1987. "Hybridization of Genomic DNA to Oligonucleotide Probes in the Presence of Tetramethylammonium Chloride. In: Methods in Enzymology, (eds. Berger, S.L. and Kimmel, A R.), vol 152, pp. 447-451.
  45. Ledley, F.D., Grenett, H.E. and Woo, S.L.C., 1987. "Structure of Aromatic Amino Acid Hydroxylases. In: S. Kaufman (ed) Amino Acids in Health and Disease: New Perspectives. UCLA Symposia on Molecular and Cellular Biology New Series V. 55. Alan R. Liss, New York. pp. 267-284.
  46. Ledley, F.D. and Woo, S.L.C., 1987. "Prospects for Somatic Gene Therapy of Phenylketonuria. In: S. Kaufman (ed) Amino Acids in Health and Disease, New Perspectives. UCLA Symposia on Molecular and Cellular Biology New Series V. 55. Alan R. Liss, New York, pp. 565-580.
  47. DiLella, A.G., Marvit, J. and Woo, S.L.C., 1987. In: Amino Acids in Health and Disease: New Perspectives, pp. 553-564, Alan R. Liss Publishers.
  48. DiLella, A.G. and Woo, S.L.C., 1987. Review: "Molecular Basis of Phenylketonuria and Its Clinical Applications". In: Molecular Biology and Medicine, Vol. 4,183-192.
  49. Woo, S.L.C., DiLella, A.G., Marvit, J. and Ledley, F.D., 1987. "Molecular Basis of Phenylketonuria and Recombinant DNA Strategies for Its Therapy". In: Recent Adv. Inborn Errors of Metabolism, Proc. 4th Int. Congr., Sendai, Japan. Enzyme 38:207-213.
  50. Carlson, J., Sifers, R.N. and Woo, S.L.C. 1988. "Molecular Defects in an Inheritable Liver Disease: Alphal-Antitrypsin Deficiency". (eds. Arias, I.M., Jakoby, W.B., Popper, H., and Shafritz, D.A.), Raven Press In: The Liver Biology and Pathobiology Second Edition:1161-­1168.
  51. Woo, S.L.C. 1988. "Molecular Biology: Phenylketonuria as a Model". In: Understanding Mental Retardation: Research Accomplishments and New Frontiers (eds. J.F. Kavanagh), Paul H. Brooks Publishing Company. pp.41-56.
  52. Woo, S.L.C. 1988. "Use of Specific Oligonucleotides for Carrier Detection and Prenatal Diagnosis of PKU" (eds. J.W. Swann and A. Messer), Alan R. Liss, Inc. In: Disorders of the Developing Nervous System: Changing Views on Their Origins, Diagnoses and Treatments. Birth Defects Symposium XVIII. pp.211-228.
  53. Ledley, F.D. and Woo, S.L.C. 1988. "Reconsidering the genetics of phenylketonuria. In: Wurtman, R.J. and Ritter-Walker, E. (Eds) Dietary Phenylalanine and Brain Function. Birkhauser, Boston/Basel. pp.228-237.
  54. Scriver, C., Kaufman, S. and Woo, S.L.C. 1988. "Mendelian Hyperphenylalaninemia" In: Ann. Rev. Genetics, (eds. Campbell, Baker, Herskowitz and Sandler). 22:301-321.
  55. Cohen, A.B., Woo, S.L.C., Kelley, R., Rosenbloom, J., Crystal, R.G., Sifers, R. and Perlmutter, D. 1988. Molecular Genetics in Pulmonary Emphysema. Am. Rev. Respir. Dis. Oct. 138(4):1041-1043.
  56. Armentano, D., Peng, H., MacKenzie-Graham, L., Seh, M., Shen, R.F., Ledley, F.D., Darlington, G. J. and Woo, S.L.C. 1989. Retroviral-mediated gene transfer on human PAH into mouse primary hepatocytes. In: UCLA Symposia on Gene Transfer into Animals. (eds. A L. Beaudet, R. Mulligan, I.M. Verma) Gene Transfer and Gene Therapy. Alan R. Liss, Inc. pp. 355-363.
  57. Scriver, C., Kaufman, S. and Woo, S.L.C. 1989. "The Hyperphenylalaninemia" In: Metabolic Basis of Inherited Diseases (eds. Scriver, C., Beaudet, A., Sly, W. and Valle, D.). 6:495-533.
  58. Woo, S.L.C., Okano, Y., Wang, T., and Eisensmith, R. 1989. Identification and screening for phenylketonuria mutations by polymerase chain reaction. In: Current Communications in Molecular Biology: Polymerase Chain Reaction (Erlich H.A., Gibbs R., Kazazian H.H., eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. pp. 57-61.
  59. Woo, S.L.C. 1989. "Phenylketonuria: Molecular Basis and Clinical Applications". In: Molecular Genetics in Diseases of Brain, Nerve, & Muscle - Neurology Primer for Clinicians (eds. L.P. Rowland, D.S. Wood, E.A. Schol, and S. DiMauro). pp. 221-234.
  60. Eisensmith, R.C., Okano, Y., Wang, T., and Woo, S.L.C. 1990. Identification and screening for phenylketonuria mutations by polymerase chain reaction. UCLA Symposium. In: Biotechnology and Human Genetic Predisposition to Disease, UCLA Symposium on Molecular and Cellular Biology, New Series 126 (Cantor C.R., Caskey C.T., Hood L.E., Kamely D., Omenn G.S., eds.) Alan R. Liss, Inc., New York. pp.39-46.
  61. Reichardt, J.K.V. and Woo, S.L.C. 1990. Direct Double-Stranded Sequencing of PCR Products United States Biochemical Corp. Vol. 17, No. 2:21-22.
  62. Eisensmith, R.C. and Woo, S.L.C. 1991. Phenylketonuria, Molecular Genetics. In: Encyclopedia of Human Biology (ed. Renato Dulbecco). Academic Press, San Diego. 5:1742-­1746.
  63. Woo, S.L.C. 1991. Molecular Genetic Analysis of Phenylketonuria and Mental Retardation. In: Genes, Brain and Behavior (ed. P.R. McHugh and V.A. McKusick) Raven Press, Ltd., NY. 69: 193-203.
  64. Eisensmith, R.C., and Woo, S.L.C. 1991. Phenylketonuria and the Phenylalanine Hydroxylase Gene. In: Molecular Biology Medicine. pp. 3-18.
  65. Kay, M., Ponder, K.P., and Woo, S.L.C. 1991. Human Gene Therapy: Present and Future. In: 14th Annual Breast Cancer Symposium. pp.83-93.
  66. Woo, S.L.C., Sifers, R.N. and Ponder, K 1992. Genetic Control of Human Alpha-1-Antitrypsin and Hepatic Gene Therapy. In: Current Topics in Rehabilitation. Biochemistry of Pulmonary Emphysema. Publisher, Springer-Verlag, NY. pp. 159-167.
  67. Shiloh, Y., Avigad, S., Kleiman, S., Weinstein, M., Schwartz, G., Woo, S.L.C. and Cohen, B.E. 1992. Molecular Analysis of Hyperphenylalaninemia in Israel: A Study of Jewish Genetic Diversity. In: Genetic Diversity Among Jews: Disease & Markers at the DNA Level. (T.B. Bonne-Tamir & A. Adam, Ed.) Oxford Press, NY, pp. 2370247.
  68. Eisensmith, R.C. and Woo, S.L.C. Molecular and Phenotypic Diversity in Phenylketonuria. In: Molecular Genetics in Neurology (ed. M. Conneally) Blackwell Scientific Publications, Cambridge 1992. pp.181-198.
  69. Sifers, R.N., Finegold, M.J., and Woo, S.L.C. 1994. Alpha 1-Antitrypsin: Molecular Defects. In: The Liver: Biology & Pathobiology 3rd Edition. Raven Press, pg. 1357.
  70. Sifers, R.N., Finegold, M., and Woo, S.L.C. 1992. Molecular Biology & Genetics of Alpha-1-Antitrypsin Deficiency Seminars in Liver Disease Vol. 12. #3, pgs.301-310.
  71. Scriver, C.R., John, S.M.W., Rozen, R., Eisensmith, R.C., and Woo, S.L.C. 1993. Associations Between Populations, Phenylketonuria Mutations and RFLP Haplotypes at the Phenylalanine Hydroxylase Locus: An Overview Developmental Brain Dysfunction Vol. 6, pgs.11-25.
  72. Woo, S.L.C., 1993. Toward Hepatic Gene Therapy for Metabolic & Cardiovascular Disease. American Heart Journal (Submitted)
  73. Kay, M.A., and Woo, S.L.C., 1994. Gene Therapy for Metabolic Disorders, Trends in Genetics Vol.10, 7:253-257.
  74. Scriver, C., Eisensmith, R. C., Woo, S.L.C. and Kaufman, S. 1994. The Hyperphenylalaninemias of Man and Mouse. Annual Review of Genetics 28:141-166.
  75. Eisensmith, R.C. and Woo, S.L.C. 1994. Population Genetics of Phenylketonuria. Acta Paediatrica Suppl. 407:19-26.
  76. Eisensmith, R.C. and Woo, S.L.C. 1994. Gene Therapy for Phenylketonuria. Acta Paediatrica Suppl. 407:124-129.
  77. Smith, L.C., Eisensmith, R.C., and Woo, S.L.C. 1994. Gene Therapy Approaches to Aherosclerosis and Metabolic Disorders. Molecular Genetics & Gene Therapy for Cardiovascular Diseases (ed. S. Mockrin). Marcel-Dekker, New York, 529-546.
  78. Scriver, C.R., Eisensmith, R.C., Kaufman, S., and Woo, S.L.C. 1994. The Hyperphenylalaninemias of Man and Mouse. Annu. Rev. Genet. 28:141-165.
  79. Smith, L.C., Sparrow, J.T., Gottschalk, S., and Woo, S.L.C. 1995. Gene Therapy for Dyslipoproteinemia and Atherosclerosis. Proceedings of the 9th International Symposium on Atherosclerosis (eds. Woodford, Darignon, Sniderman) Amsterdam, Elsevier, 553-556
  80. Smith, L.C., Eisensmith, R.C., and Woo, S.L.C. 1995. Gene Therapy in Heart Disease. Nutrition and Biotechnology in Heart Disease and Cancer pp. 79-88.
  81. Eisensmith, R.C. and Woo, S.L.C. 1995. Molecular Genetics of Phenylketonuria: From Molecular Anthropology to Gene Therapy. Advances in Genetics - Vol.32 pp. 199-272.
  82. Scriver, C. R., Kaufman, S., Eisensmith, R. C. and Woo, S. L. C. 1995. The Hyperphenylalaninemias. The Metabolic and Molecular Bases of Inherited Disease, volume 1, 7th ed. pp. 1015-1075.
  83. Eisensmith, R.C., and Woo, S.L.C. 1995. Molecular Genetics of Phenylketonuria. In: Molecular Biology and Biotechnology, A Comprehensive Desk Reference (ed. R Meyers). VCH Publishers, New York 678-680
  84. Fang, B., Eisensmith, R.C., and Woo, S.L.C. 1995. Phenylketonuria: A Model for Hepatic Gene Therapy. Mental Retard. and Dev. Disabilities Res. Rev. 1:56-61
  85. Eisensmith, R.C. and S. L. C. Woo. 1996. Somatic gene therapy for phenylketonuria and other metabolic deficiencies. J Inher Metab Dis 19:412-423
  86. Shine, D.H. and Woo, S.L.C. 1996. Adenovirus-Mediated Gene Therapy of Tumors in the Central Nervous System. Genetic Manipulation of the Nervous System pp. 53-71.
  87. Bowles, N., and Woo, S.L.C. 1995. "Gene Therapy for Metabolic Disorders". In: Advanced Drug Delivery Reviews, (eds. E. tomlinson, S. Hirota, V.H.L. Lee, and W.W. Pouton) Elsevier, Amsterdam, pp. 293-302.
  88. Woo, S.L.C. 1996. Gene Therapy: "Beyond Genetic Diseases." In: Biotechnology -Science, Engineering, and Ethical Challenges for the Twenty-First Century- (eds. F.B. Rudloph and L.V. McIntire) Joseph Henry Press, Washington, D.C. pp.72-87
  89. Kwong, Y.L, Chen, S.H., Woo, S.L.C. 1997 Methods for Cancer Gene Therapy Current Protocols in Human Genetics, John Wiley & Sons, 13.5.1-13.5.23.
  90. Eisensmith, R.C. and S. L. C. Woo. Gene Therapy of Phenylketonuria. Eur J.Pediatr, Supplement 1: Volume 155 pp.16-19
  91. Block, A., Chen, S.H., Rich, S., Woo, S.L.C. 1996 Handbook of Immune Modulating Agents. Immunomodulation in Gene Therapeutics (Submitted)
  92. Eisensmith, R.C. and Woo, S.L.C. 1996. Correction of the Genetic Defecting Alpha-1 Antitrypsin Deficiency by Somatic Gene Therapy. In: Gene Therapy for Diseases of the Lung (eds. C. Lenfant and KL Brigham) Marcel Dekker, New York; pp. 267-284.
  93. Smith L.C., Sparrow J.T., Gottschalk S., Woo S.L.C. 1996. Gene Therapy for dyslipoproteinemia and atherosclerosis. In: Atherosclerosis X; eds Woodford FP, Davignon J, Sniderman A; Amsterdam; Elsevier; 553-556.
  94. Smith L.C., Gottschalk S., Hauer J., Woo S.L.C., Sparrow J.T. 1996 Non-viral gene delivery using DNA: Synthetic peptide complexes. In: Proc Xiith Int. Symp. Drug Affecting Lipid Metabolism; eds. Gotto, Paolette, Smith, Catagano, Jackson; 337-346
  95. Sparrow J.T., Woo, S.L.C., Gottschalk S., Duguid J., Li C., Smith L.C. 1996 Synthetic vehicles for non-viral somatic gene therapy. In: Peptides 1995 (Proceedings of the 14th American Peptide Symposium); Leiden; Escom; 561-562
  96. Woo, S.L.C. 1996, Adenovirus Redirected. Nature Biotech. 14: p. 1538. (editorial).
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  105. Woo, S.L.C., 2000. Policy of the American Society of Gene Therapy on Financial Conflict of Interest in Clinical Research. Molecular Therapy 5:383-384.
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  108. Woo, S.L.C., 2000. Gene Therapy Commentary. FDA Consumer.
  109. Woo, S.L.C., 2001. Clinical Gene Transfer: Education is the Key. Molecular Therapy 4:92.
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  112. Dong, H.J. and Woo, S.L.C. 2001. Hepatic Insulin Production for Type 1 Diabetes. Trends in Endocrinology and Metabolism. 12:441-447.
  113. Sung, M.W., Chen, S.H. and Woo, S.L.C. 2002. New Approaches to Gene Therapy for Cancer. In: Progress in Oncology (Eds. DeVita, Hellman and Rosenberg), Jones and Bartlett press, pp.36-53.
 
Updated: October 19, 2006