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NIH Mouse Genotyping Service The Center for Inherited Disease Research (CIDR) is an NIH-supported resource providing high throughput genotyping services to research efforts that are attempting to identify genetic loci and allelic variants involved in human disease. The Center offers genotyping services to investigators conducting mapping studies with inbred strains of mice. Genotyping services are also offered to investigators who wish to use marker-assisted breeding strategies to construct congenic or consomic lines of mice. Using DNA samples provided by the principal investigator, CIDR carries out genome-wide scans using automated fluorescent technology to genotype microsatellite markers. All data will remain the property of the principal investigator and will be returned once the studies at CIDR are complete. A total of 54 inbred strains have been typed. A list of the strains, along with allele sizes for ~300 markers, is available on the CIDR web site. Only projects that request the typing of at least 80 animals will be accepted. CIDR is a joint effort by twelve participating institutes at NIH: the National Cancer Institute, the National Eye Institute, the National Human Genome Research Institute, the National Institute on Aging, the National Institute of Child Health and Human Development, the National Institute of Dental and Craniofacial Research, the National Institute on Deafness and Other Communication Disorders, the National Institute of Diabetes and Digestive and Kidney Disease, the National Institute on Drug Abuse, the National Institute of Environmental Health Sciences, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke. CIDR is located at the Bayview Research Campus of the Johns Hopkins University and is operated by the University through a contract from the NIH. Investigators whose mapping projects are supported by one of the twelve NIH Institutes participating in CIDR will receive free genotyping. Other investigators are eligible to use CIDR on a fee for service basis. Access to CIDR is open to all investigators on a competitive basis through peer review. For a more complete description of CIDR, including specific application procedures, visit our Website at http://www.cidr.jhmi.edu/. Application deadlines are March 1, July 1,and November 1. For additional information about the NIH Mouse Genotyping Service, please contact: Jerry Roberts, Ph.D.
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