The Cancer Cell Biology Branch (CCBB) encourages and supports basic research projects covering a broad spectrum of topics directed at understanding the biological basis of cancer. The Branch portfolio includes the search for genes, proteins and networks responsible for the cancer phenotype, investigation of aberrantly modified regulatory processes that promote cell proliferation or inhibit cell death, and the identification of connecting pathways that ensure tumor cell survival. The research supported by the Branch portfolio utilizes biochemical approaches, in vitro approaches with human tumor cells and tissues and in vivo approaches with non-mammalian model organisms and mammalian models to explore functional consequences of abnormal gene expression. Investigations in all tumor cell types are included. The ultimate goal of the Cancer Cell Biology program is the discovery of new information that has practical application to cancer detection or treatment.
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| PAS-06-205 | -Understanding and Treating Tuberous Sclerosis Complex (R03) |
| PAS-06-206 | -Understanding and Treating Tuberous Sclerosis Complex (R21) |
| PA-04-125 | -Novel Approaches To Enhance Animal Stem Cell Research |
| PAS-05-085 | -Understanding and Treating Tuberous Sclerosis Complex (R01) |
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| Name | Title |
| Spalholz, Barbara, Ph.D. | Chief |
| Lei, Ming, Ph.D. | Program Director |
| Salnikow, Konstantin, Ph.D. | Program Director |
| Yassin, Rihab, Ph.D. | Program Director |
| Kave, Joyce | Extramural Support Asst. |
| Strasburger, Jennifer | Program Assoc. Director |
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| Cellular Transformation |
The Cellular Transformation program area, directed by Dr. Donald Blair, supports studies on the role and function of oncogenes, the p53 family of proteins, and stem cells in the initial stages of cancer. It also supports studies of the cnacer-associated perturbations of cellular differentiation, the role of developmental genes and pathways in cancer; and the relationship between cellular aging, senescence, and cancer.
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| Cancer Cell Biology |
The Cancer Cell Biology program area, directed by Dr. Barbara Spalholz, supports basic molecular biology studies on the cell cycle and its regulation; DNA replication and cell division; programmed cell death and autophagy. Emphasis is focused on the failure of normal processes that leads to cancer.
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| Conference, AREA and SBIR/STTR Grants |
Conference grants, Academic Research Enhancement Awards, and Small Business Innovation Research grants relevant to the various cancer cell biology programs described above are managed by Ms. Jennifer Strasburger.
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| Signal Transduction in Transformation |
The Signal Transduction in Transformation program area, directed by Dr. Rihab Yassin, supports studies on the functional and biochemical characterization of signal transduction pathways/networks relating to cell survival and death in the context of transformation; signaling by cytokines, protein kinases, phosphatases, lipids or other molecules, including the analysis of the composition, formation, and functioning of signaling complexes; and the role of oxidative stress and inflammation in cellular transformation. Dr. Yassin also manages a portfolio of research grants studying the function of tumor suppressors, other than p53, in cancer.
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