Biography:

Dr. An obtained his M.D. from Lanzhou Medical College in 1985, followed by an M.S. in the specialty of Infectious Diseases in1988. He received his MPH Degree in 2004 from the Johns Hopkins University Bloomberg School of Public Health in Baltimore, MD, with a concentration in genetic epidemiology. Dr. An was an infectious disease clinician and researcher from 1988-1995 at the Lanzhou Medical College, First Hospital. He did a fellowship in the Laboratory of Genomic Diversity from 1995-1998. Since 1998, Dr. An has been a scientist in the Laboratory of Genomic Diversity, Molecular Genetic Epidemiology Section, SAIC-Frederick. His primary research interest is investigating the role of host genetics in susceptibility and resistance to infectious diseases.

Research:

1. Host genetics on HIV-1--- Using a population-based approach, we are investigating the role of host genetic factors, particularly those involved in innate immunity, that confer resistance or susceptibility to HIV-1. (Read more)
2. Host genetics on HBV and HCV--- We are investigating host genetic factors that confer host resistance or susceptibility to hepatitis B virus (HBV) and hepatitis C virus (HCV), by genetic association study of several case-control samples from the USA and China.

Publications:

An, P., Duggal, P., Wang, L.H., O'Brien, S.J., Donfield, S., Goedert, J.J., Phair, J., Buchbinder, S., Kirk, G.D. and Winkler, C.A. (2007) Polymorphisms of CUL5 Are Associated with CD4 + T Cell Loss in HIV-1 Infected Individuals. PLoS Genetics, 3, e19. [ PDF ]

Javanbakht, H., An, P., Gold, B., Petersen, D.C., O'Huigin, C., Nelson, G.W., O'Brien, S.J., Kirk, G.D., Detels, R., Buchbinder, S. et al. (2006) Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology, 354, 15-27. [ PDF ]

An, P., Bleiber, G., Duggal, P., Nelson, G., May, M., Mangeat, B., Alobwede, I., Trono, D., Vlahov, D., Donfield, S. et al . (2004) APOBEC3G genetic variants and their influence on the progression to AIDS. J Virol, 78, 11070-6. [ PDF ]

An, P., Nelson, G.W., Wang, L., Donfield, S., Goedert, J.J., Phair, J., Vlahov, D., Buchbinder, S., Farrar, W.L., Modi, W. et al. (2002) Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proc Natl Acad Sci U S A, 99, 10002-7. [ PDF ]

An, P., Vlahov, D., Margolick, J.B., Phair, J., O'Brien, T.R., Lautenberger, J., O'Brien, S.J. and Winkler, C.A. (2003) A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. J Infect Dis, 188, 228-31. [ PDF ]

Modi, W.S., Lautenberger, J., An, P., Scott, K., Goedert, J.J., Kirk, G.D., Buchbinder, S., Phair, J., Donfield, S., O'Brien, S.J. et al. (2006) Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression. Am J Hum Genet, 79, 120-8. [ PDF ]

An, P., Martin, M.P., Nelson, G.W., Carrington, M., Smith, M.W., Gong, K., Vlahov, D., O'Brien, S.J. and Winkler, C.A. (2000) Influence of CCR5 promoter haplotypes on AIDS progression in African-Americans. Aids, 14, 2117-22.