Trichlorofluoromethane (CASRN 75-69-4)
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0120
Trichlorofluoromethane;
CASRN 75-69-4
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Trichlorofluoromethane
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 08/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
Last Revised — 08/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Survival and Cancer Bioassay NCI, 1978 |
NOAEL: none LOAEL: 488 mg/kg/day |
1000
|
1
|
3E-1
mg/kg/day |
*Conversion Factors: 5 days/7 days; thus, 488 mg/kg/day x 5 days/7 days = 349 mg/kg/day
__I.A.2. Principal and Supporting Studies (Oral RfD)
NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane
for possible carcinogenicity. Report. No. 106, PHS/NIH, DHEW Publ. No. 78-
1356.
The NCI bioassay was performed on rats and mice exposed to various doses of
trichloromonofluoromethane by gavage over a period of 78 weeks (50
animals/species/sex/dose for each of two doses with 20 animals/species/sex for
each of two control groups). A statistically significant positive association
between increased dosage and accelerated mortality by the Tarone test in male
and female rats and female mice were observed. In treated rats of both sexes
there were also elevated incidences of pleuritis and pericarditis not seen in
controls. Inhalation studies which employed multispecies exposures to higher
levels of the compound than used by NCI (Leuschner et al., 1983) reported no
adverse clinical/pathologic signs of toxicity due to subchronic or short-term
exposures.
The LOAEL of 488 mg/kg/day (based on mortality in rats) was converted to 349
mg/kg/day on a 7-day exposure basis.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factory of 1000 (10 for LOAEL, 10 for species conversion,
and 10 for sensitive human population), results in an RfD of 0.3 mg/kg/day.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
None.
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Medium
RfD — Medium
The chosen study is given a medium confidence rating because large numbers of animals/sex were tested in two doses for chronic exposures, but the study did not establish a NOEL. The database is given a medium confidence rating because of the support of chronic data, but the lack of reproductive data. Medium confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation — None
Agency Work Group Review — 05/20/1985, 05/31/1985
Verification Date — 05/31/1985
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Trichlorofluoromethane conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
Last Revised — 07/01/1992
_VI.A. Oral RfD References
Leuschener, F., B.W. Neumann and F. Hubscher. 1983. Report on the subacute
toxicological studies with several fluorocarbons in rats and dogs by
inhalation. Arzneim-Forsch. 33(10): 1475-1476.
NCI (National Cancer Institute). 1978. Bioassay of trichlorofluoromethane
for possible carcinogenicity. Report No. 106, PHS/NIH, DWEH, Publ. No. 78-
1356.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
Date |
Section |
Description |
---|---|---|
03/31/1987 | I.A.6. | Documentation corrected |
03/01/1988 | I.A.5. | Confidence levels revised |
08/01/1990 | I.A. | Text edited |
08/01/1990 | IV.F.1. | EPA contact changed |
01/01/1992 | I.A.7. | Primary contact changed |
01/01/1992 | IV. | Regulatory actions updated |
07/01/1992 | I.A.2. | Citations removed |
07/01/1992 | VI.A. | Oral RfD references on-line |
08/01/1992 | I.A.3. | Minor text change |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Trichlorofluoromethane
CASRN — 75-69-4
Last Revised — 01/31/1987
- 75-69-4
- ALGOFRENE TYPE 1
- ARCTON 9
- ELECTRO-CF 11
- ESKIMON 11
- F 11
- FC 11
- FLUOROCARBON NO. 11
- FLUOROTRICHLOROMETHANE
- FLUOROTROJCHLOROMETAN
- FREON 11
- FREON 11A
- FREON 11B
- FREON HE
- FREON MF
- FRIGEN 11
- GENETRON 11
- HALOCARBON 11
- ISCEON 131
- ISOTRON 11
- LEDON 11
- MONOFLUOROTRICHLOROMETHANE
- NCI-C04637
- RCRA WASTE NUMBER U121
- Trichlorofluoromethane
- TRICHLOROMONOFLUOROMETHANE
- UCON FLUROCARBON 11
- UCON REFRIGERANT 11