Carbosulfan (CASRN 55285-14-8)
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0021
Carbosulfan;
CASRN 55285-14-8
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Carbosulfan
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 12/01/1988 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Carbosulfan
CASRN — 55285-14-8
Last Revised — 12/01/1988
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF
|
MF
|
RfD
|
---|---|---|---|---|
Decreased body weight 2-Year Rat Feeding FMC, 1982a |
NOEL: 20 ppm diet LEL: 500 ppm diet |
100
|
1
|
1E-2
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
FMC Corporation. 1982a. MRID No. 00093945, 00118390. Available from EPA. Write to FOI, EPA, Washington DC 20460.
Sixty male and 60 female Sprague-Dawley rats per dose were administered in their diet 0, 10, 20, 500, and 2500 ppm of carbosulfan for 24 months. Parameters evaluated were mortality, body weight, food consumption, water consumption, ophthalmoscopic examination, cholinesterase evaluation, hematology evaluation, clinical chemistry, urinalysis, necropsy evaluation, organ weights, and histopathologic evaluation of tissue. At 500 ppm, decreased body weight and food consumption, and increased incidence of toxic signs were observed. Brain, plasma and RBC cholinesterase inhibition was also observed at 500 ppm.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — Based on a chronic exposure study, an uncertainty factor of 100 was used to account for inter- and intraspecies differences.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
- 2-Year Feeding (oncogenic) - rat: Principal study - see previous description; core grade minimum
- 3-Generation Reproduction - rat: NOEL=1 mg/kg/day; LEL=12.5 mg/kg/day (decreased pup weight and viability); core grade minimum (FMC Corp., 1982b)
- 6-Month Feeding - dog: ChE NOEL=1.25 mg/kg/day; ChE LEL=12.5 mg/kg/day (plasma and RBC inhibition); core grade minimum (FMC Corp., 1980a)
- Teratology - rat: Fetotoxic and Maternal NOEL=2 mg/kg/day; Fetotoxic and Maternal LEL=10 mg/kg/day (decreased body weight); core grade mimimum (FMC Corp., 1980b)
- Teratology - rabbit: Fetotoxic NOEL=5 mg/kg/day; LEL=10 mg/kg/day (decreased body weight); core grade mimimum (FMC Corp., 1980c)
Other Data Reviewed:
1) 2-Year Feeding (oncogenic) - mice: ChE NOEL=10 ppm or 1.5 mg/kg/day; Plasma ChE LEL=20 ppm or 3 mg/kg/day; core grade minimum (FMC Corp., 1982c)
Data Gap(s): None
__I.A.5. Confidence in the Oral RfD
Study — High
Database — High
RfD — High
The principal study appears to be of good quality and is given a high confidence rating. Additional studies are supportive and therefore, the data base is given a high confidence rating. High confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Files
Agency Work Group Review — 06/10/1986
Verification Date — 06/10/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Carbosulfan conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Carbosulfan
CASRN — 55285-14-8
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Carbosulfan
CASRN — 55285-14-8
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Carbosulfan
CASRN — 55285-14-8
Last Revised — 11/01/1989
_VI.A. Oral RfD References
FMC Corporation. 1980a. MRID No. 00063729. Available from EPA. Write to FOI, EPA, Washington DC 20460.
FMC Corporation. 1980b. MRID No. 00063726. Available from EPA. Write to FOI, EPA, Washington DC 20460.
FMC Corporation. 1980c. MRID No. 00063727. Available from EPA. Write to FOI, EPA, Washington DC 20460.
FMC Corporation. 1982a. MRID No. 00093945, 00118390. Available from EPA. Write to FOI, EPA, Washington DC 20460.
FMC Corporation. 1982b. MRID No. 00093949, 00115230. Available from EPA. Write to FOI, EPA, Washington DC 20460.
FMC Corporation. 1982c. MRID No. 00093951, 00118391. Available from EPA. Write to FOI, EPA, Washington DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Carbosulfan
CASRN — 55285-14-8
Date |
Section |
Description |
---|---|---|
03/01/1988 | I.A.1. | Critical effect corrected |
06/30/1988 | I.A.2. | Description of effects revised |
06/30/1988 | I.A.4. | Study descriptions clarified |
12/01/1988 | I.A.4. | Study 1) core grade added |
11/01/1989 | VI. | Bibliography on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Carbosulfan
CASRN — 55285-14-8
Last Revised — 01/31/1987
- 55285-14-8
- ADVANTAGE
- CARBAMIC ACID, ((DIBUTYLAMINO)THIO)METHYL-, 2,2-DIMETHYL-2,3-DIHYDRO-7- BENZOFURANYL ESTER
- Carbosulfan
- ((DIBUTYLAMINO)THIO)METHYLCARBAMIC ACID, 2,2-DIMETHYL-2,3-DIHYDRO-7- BENZOFURANYL ESTER
- 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANYL(DI-n-BUTYLAMINOSULFENYL)METHYLCARBAMATE
- 2,3-DIHYDRO-2,2-DIMETHYL-7-BENZOFURANYL((DIBUTYLAMINO)THIO)METHYL CARBAMATE
- FMC 35001
- MARSHAL