Diazomethane (CASRN 334-88-3)
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0616
Diazomethane; CASRN 334-88-3
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Diazomethane
File First On-Line 11/01/1991
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | |
Inhalation RfC Assessment (I.B.) | message | 11/01/1991 |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Diazomethane
CASRN — 334-88-3
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Diazomethane
CASRN — 334-88-3
The health effects data for diazomethane were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status for this chemical is currently not verifiable. No EPA documentation presently exists for this chemical.
Agency Work Group Review — 09/12/1991
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for Diazomethane conducted in November 2001 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
EPA Contacts:
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Diazomethane
CASRN — 334-88-3
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Diazomethane
CASRN — 334-88-3
Last Revised — 11/01/1991
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
None available
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Diazomethane
CASRN — 334-88-3
Date |
Section |
Description |
---|---|---|
10/01/1991 | I.B. | Inhalation RfC now under review |
11/01/1991 | I.B. | Inhalation RfC message on-line |
11/01/1991 | VI. | Bibliography on-line; no RfC references available |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.B. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Diazomethane
CASRN — 334-88-3
Last Revised — 11/01/1991
- 334-88-3
- Methane, diazo-
- Diazomethane
- Azimethylene
- CCRIS 205
- Diazirine
- DIAZONIUM, METHYLIDE
- HSDB 1628