IRIS Guidance Documents
- EPA Cancer Guidelines
- EPA Risk Guidelines (Other than Cancer)
- EPA Science Policy Council Guidelines
- Other Guidance Documents
- References Cited in Older Assessment Documents but Superseded by More Recent Guidance
These Guidance documents are listed by date (grouped by type). Many are now available online, but those that are not can be requested by contacting the IRIS Hotline at (202) 566-1676 (phone), (202) 566-1749 (Fax), or hotline.iris@epa.gov (email).
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EPA Cancer Guidelines
- U.S. EPA. 2005. Guidelines for Carcinogen Risk Assessment (PDF) (166 pp, 468 Kb). EPA/630/P-03/001F, Mar 2005.
- U.S. EPA. 2005. Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens (PDF) (125 pp, 965 Kb). EPA/630/R-03/003F, Mar 2005.
- U.S. EPA. 1999. Guidelines for Carcinogen Risk Assessment (PDF) (211 pp, 1 M). Review draft. NCEA-F-0644, Jul 1999.
- U.S. EPA. 1996. Proposed Guidelines for Carcinogen Risk Assessment (PDF) (143 pp, 425 Kb). EPA/600/P-92/003C, Apr 1996.
- U.S. EPA. 1986. Guidelines for Carcinogen Risk Assessment (PDF) (38 pp, 163 Kb). EPA/630/R-00/004, Sep 1986.
EPA Risk Guidelines (Other than Cancer)
- U.S. EPA. 2000. Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures (PDF) (209 pp, 1.1 M). EPA/630/R-00/002, Aug 2000.
- U.S. EPA. 1998. Guidelines for Neurotoxicity Risk Assessment (PDF) (89 pp, 182 Kb). EPA/630/R-95/001F, Apr 1998.
- U.S. EPA, 1996. Guidelines for Reproductive Toxicity Risk Assessment (PDF) (143 pp, 322 Kb). EPA/630/R-96/009, Oct 1996.
- U.S. EPA. 1991. Guidelines for Developmental Toxicity Risk Assessment (PDF) (83 pp, 189 Kb). EPA/600/FR-91/001, Dec 1991.
- U.S. EPA. 1987. Risk Assessment Guidelines of 1986. EPA/600/8-87/045, Sep 1987.
- U.S. EPA. 1986. Guidelines for Mutagenicity Risk Assessment (PDF) (23 pp, 253 Kb). EPA/630/R-98/003, Sep 1986.
- U.S. EPA. 1986. Guidelines for the Health Risk Assessment of Chemical Mixtures (PDF) (38 pp, 299 Kb). EPA/630/R-98/002, Sep 1986.
EPA Science Policy Council Guidelines
- U.S. EPA. 2006. Science Policy Council Handbook: Peer Review (PDF) (190 pp, 1.1 M). Third edition. Office of Science Policy, Office of Research and Development, Washington, DC. EPA/100/B-06/002.
- U.S. EPA. 2000. Science Policy Council Handbook: Risk Characterization (PDF) (189 pp, 8.9 M). Office of Science Policy, Office of Research and Development, Washington, DC. EPA 100-B-00-002.
- U.S. EPA. 2000. Science Policy Council Handbook: Peer Review (PDF) (185 pp, 3.6M). Second edition. Office of Science Policy, Office of Research and Development, Washington, DC. EPA 100-B-00-001
Other Guidance Documents
- U.S. EPA. 2002. A Review of the Reference Dose and Reference Concentration Processes (PDF) (192 pp, 2.8 M). EPA/630/P-02/002F, Dec 2002.
- U.S. EPA. 2000. Benchmark Dose Technical Guidance Document (PDF) (96 pp, 830Kb). External Review Draft. EPA/630/R-00/001, Oct 2000.
- U.S. EPA. 1994. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. EPA/600/8-90/066F, Oct 1994.
- U.S. EPA. 1994. Interim policy for particle size and limit concentration issues in inhalation toxicity studies: Notice of availability. Federal Register Notice 59(206): 53799.
- U.S. EPA. 1988. Recommendations for and Documentation of Biological Values for use in Risk Assessment. EPA 600/6-87/008, Feb 1988.
References Cited in Older Assessment Documents but Superseded by More Recent Guidance
- U.S. EPA. 1993. Reference Dose (RfD): Description and Use in Health Risk Assessments Mar 1993.
- U.S. EPA. 1992. EPA's Approach for Assessing the Risks Associated with Chronic Exposures to Carcinogens Jan 1992.