Propham (CASRN 122-42-9)
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0260
Propham;
CASRN 122-42-9
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Propham
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 09/30/1987 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Propham
CASRN — 122-42-9
Last Revised — 09/30/1987
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Increase in male 90-Day Rat Feeding PPG Industries, 1979 |
NOEL: 1000 ppm diet LEL: 2000 ppm diet |
3000
|
1
|
2E-2
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
PPG Industries, Inc. 1979. Accession No. 250614, 250615. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Sprague-Dawley rats (a minimum of 20/sex/dose) were fed 0, 250, 1000, and 2000 ppm of propham in their diets for 90 consecutive days. The animals were observed daily for behavioral changes and signs of toxicity. At 45 days, there was ChE depression in female rats at 100 mg/kg/day. In male rats, at 100 mg/kg/day, an increase in spleen weight occurred.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 1000 was used to account for the inter- and intraspecies differences and a subchronic to chronic exposure extrapolation. An additional UF of 3 was used to account for the fact that the database lacks important toxicity data (a study in a second mammalian species and a reproduction study).
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 90-Day Feeding - rat: Principal study - see previous description; core grade minimum
Data Gap(s): Chronic Feeding Rat Study; Chronic Feeding Dog Study; Rat Reproduction Study; Rat Teratology Study; Rabbit Teratology
__I.A.5. Confidence in the Oral RfD
Study — Low
Database — Low
RfD — Low
The principal study was of low quality and is given a low confidence rating. The supporting database is incomplete and is given a low confidence rating. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA document.
Other EPA Documentation — Pesticide Registration Files
Agency Work Group Review — 09/02/1986, 03/18/1987
Verification Date — 03/18/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Propham conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Propham
CASRN — 122-42-9
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Propham
CASRN — 122-42-9
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Propham
CASRN — 122-42-9
Last Revised — 02/01/1993
_VI.A. Oral RfD References
PPG Industries, Inc. 1979. Accession No. 250614, 250615. Available from EPA. Write to FOI, EPA, Washington DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Propham
CASRN — 122-42-9
Date |
Section |
Description |
---|---|---|
12/01/1989 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
02/01/1993 | III.A. | Health Advisory on-lin |
02/01/1993 | VI.D. | Health Advisory references on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Propham
CASRN — 122-42-9
Last Revised — 09/30/1987
- 122-42-9
- BAN-HOE
- BEET-KLEEN
- CARBANILIC ACID, ISOPROPYL ESTER
- CHEM-HOE
- IFC
- IFK
- INPC
- IPC
- IPPC
- ISO.PPC.
- ISOPROPIL-N-FENIL-CARBAMMATO
- ISOPROPYL CARBANILATE
- ISOPROPYL CARBANILIC ACID ESTER
- ISOPROPYL-N-FENYL-CARBAMAAT
- ISOPROPYL-N-PHENYL-CARBAMAT
- ISOPROPYL-N-PHENYLCARBAMATE
- ISOPROPYL-N-PHENYLURETHAN
- ISOPROPYL PHENYLCARBAMATE
- N-PHENYLCARBAMATE D'ISOPROPYLE
- N-PHENYLCARBAMIC ACID, ISOPROPYL ESTER
- N-PHENYL ISOPROPYL CARBAMATE
- O-ISOPROPYL N-PHENYL CARBAMATE
- ORTHO GRASS KILLER
- PHENYLCARBAMIC ACID, 1-METHYLETHYL ESTER
- PREMALOX
- PROFAM
- Propham
- PROPHAME
- TRIHERBIDE
- TRIHERBIDE-IPC
- TUBERIT
- TUBERITE
- USAF D-9
- Y 2