p-Nitrophenol (CASRN 100-02-7)
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0484
p-Nitrophenol; CASRN 100-02-7
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR p-Nitrophenol
File First On-Line 10/01/1991
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | |
Inhalation RfC Assessment (I.B.) | message | 10/01/1991 |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — p-Nitrophenol
CASRN — 100-02-7
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — p-Nitrophenol
CASRN — 100-02-7
The health effects data for 4-nitrophenol were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status for this chemical is currently not verifiable. For additional informationon health effects of this chemical, interested parties are referred to the documentation listed below.
U.S. EPA. 1980. Ambient Water Quality Criteria Document for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Criteria and Standards Division, Washington, DC. October. EPA 440/5-80-063.
U.S. EPA. 1985. Health and Environmental Effects Profile for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
U.S. EPA. 1987. Health Effects Assessment for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteia and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
Agency Work Group Review — 06/13/1991
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfC for p-Nitrophenol conducted in November 2001 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
EPA Contacts:
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — p-Nitrophenol
CASRN — 100-02-7
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — p-Nitrophenol
CASRN — 100-02-7
Last Revised — 10/01/1991
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
U.S. EPA. 1980. Ambient Water Quality Criteria Document for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Criteria and Standards Division, Washington, DC. October. EPA 440/5-80-063.
U.S. EPA. 1985. Health and Environmental Effects Profile for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
U.S. EPA. 1987. Health Effects Assessment for Nitrophenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteia and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — p-Nitrophenol
CASRN — 100-02-7
Date |
Section |
Description |
---|---|---|
08/01/1991 | I.A. | Oral RfD now under review |
08/01/1991 | I.B. | Inhalation RfC now under review |
10/01/1991 | I.B. | Inhalation RfC message on-line |
10/01/1991 | VI. | Bibliography on-line |
08/01/1995 | I.A | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.B. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — p-Nitrophenol
CASRN — 100-02-7
Last Revised — 10/01/1991
- 100-02-7
- 4-HYDROXYNITROBENZENE
- 4-NITROFENOL [DUTCH]
- 4-NITROPHENOL
- CASWELL NO. 603
- EPA PESTICIDE CHEMICAL CODE 056301
- HSDB 1157
- NCI-C55992
- NIPHEN
- NSC 1317
- PARANITROFENOL [DUTCH]
- PARANITROFENOLO [ITALIAN]
- PHENOL, 4-NITRO-
- PHENOL, P-NITRO-
- P-HYDROXYNITROBENZENE
- P-NITROFENOL [CZECH]
- P-NITROPHENOL
- RCRA WASTE NUMBER U170