Tetrachlorovinphos (CASRN 961-11-5)
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0194
Tetrachlorovinphos;
CASRN 961-11-5
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Tetrachlorovinphos
File First On-Line 03/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 01/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Last Revised — 01/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Reduced body weight Two-Year Dog Feeding Shell Chemical Co., |
NOEL: 125 ppm (diet) LEL: 2000 ppm (diet) |
100
|
1
|
3E-2
mg/kg/day |
*Dose Conversion Factors & Assumptions: 1 ppm = 0.025 mg/kg/day (assumed dog food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Shell Chemical Company. 1968. MRID No. 00077819; HED Doc. No. 002607.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Five groups of six purebred beagle dogs (3 males and 3 females) were
maintained on diets containing 0, 5, 25, 125 and 2000 ppm of
tetrachlorovinphos for 104 weeks. At weeks 2, 4, 13, 26, 52, 78 and 103,
clinical tests were performed. At week 104, animals were sacrificed and gross
autopsy performed. Erythrocyte and plasma cholinesterase was depressed at
2000 ppm. A decrease in body weight gain and an increase in the organ/body
weight ratios for the kidney and liver were observed at 2000 ppm.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for inter- and
intraspecies differences.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
None.
Data Considered for Establishing the RfD:
1) 2-Year Feeding - dog: Principal study - see previous description; core grade minimum
2) 2-Year Feeding/Oncogenic - rat: Systemic and ChE NOEL=6.25 mg/kg/day;
Systemic and ChE LEL=100 mg/kg/day [reduced body weight (systemic) and RBC ChE
inhibition]; core grade minimum (Shell Chemical Co., 1966a)
3) 3-Generation Reproduction - rat: NOEL=16.5 mg/kg/day; LEL=50 mg/kg/day;
weanling liver size increased); core grade minimum (Shell Chemical Co., 1966b)
4) Teratology - rabbit: Fetotoxic NOEL=150 mg/kg/day; Fetotoxic LEL=350
mg/kg/day (reduction in viable fetuses); core grade minimum (Diamond Shamrock
Agricultural Chemicals, 1982)
Data Gap(s): Teratology - Rat
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Medium
RfD — Medium
The critical study is of good quality and is given a medium confidence rating. Additional studies are supportive; therefore, confidence in the database can be considered medium to high. Confidence in the RfD can also be considered medium to high.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Files
Agency Work Group Review — 09/02/1986
Verification Date — 09/02/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for tetrachlorovinphos conducted in August 2003 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Last Revised — 01/01/1992
_VI.A. Oral RfD References
Diamond Shamrock Agricultural Chemicals. 1982. MRID No. 00127831; HED Doc.
No. 003661. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1966a. MRID No. 00077803, 00112525; HED Doc. No.
002607. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1966b. MRID No. 00043486, 00077802, 00112522; HED
Doc. No. 002607. Available from EPA. Write to FOI, EPA, Washington, DC
20460.
Shell Chemical Company. 1968. MRID No. 00077819; HED Doc. No. 002607.
Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Date |
Section |
Description |
---|---|---|
01/01/1992 | I.A.4. | Citations added |
01/01/1992 | VI. | Bibliography on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
10/28/2003 | I.A.6 | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Tetrachlorovinphos
CASRN — 961-11-5
Last Revised — 03/31/1987
- 961-11-5
- BENZYL ALCOHOL, 2,4,5-TRICHLORO-alpha-(CHLOROMETHYLENE)-,DIMETHYL PHOSPHATE
- 2-CHLORO-1-(2,4,5-TRICHLOROPHENYL)VINYL DIMETHYL PHOSPHATE
- 2-CHLORO-1-(2,4,5-TRICHLOROPHENYL)VINYL PHOSPHORIC ACID DIMETHYL ESTER
- IPO 8
- NCI C00168
- O,O-DIMETHYL-O-2-CHLOR-1-(2,4,5-TRICHLORPHENYL)-VINYL-PHOSPHAT
- PHOSPHORIC ACID, 2-CHLORO-1-(2,4,5-TRICHLOROPHENYL)ETHENYL DIMETHYL ESTER
- PHOSPHORIC ACID, 2-CHLORO-1-(2,4,5-TRICHLOROPHENYL)VINYL DIMETHYL ESTER
- Tetrachlorovinphos
- TETRACHLORVINPHOS
- 2,4,5-TRICHLORO-alpha-(CHLOROMETHYLENE)BENZYL PHOSPHATE