S-Ethyl dipropylthiocarbamate (EPTC) (CASRN 759-94-4)
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0237
S-Ethyl dipropylthiocarbamate (EPTC);
CASRN 759-94-4
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR EPTC
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 09/01/1990 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
Last Revised — 09/01/1990
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Degenerative 2-Generation PPG Industries, 1986a |
NOEL: 50 ppm diet LEL: 200 ppm diet |
100
|
1
|
2.5E-2
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
PPG Industries, Inc. 1986a. MRID No. 00161597. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Crl:CD(SD)Br rats (30/sex/group) were fed diets providing 0, 50, 200, and 800 ppm EPTC. At 200 ppm and above, parental toxicity consisted of reduced body weights and weight gains, and a dose-related increased incidence of degenerative cardiomyopathy. Reproductive/developmental toxicity consisted of reduced pup weights at 800 ppm in both generations.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 2-Generation Reproduction - rat: Principal study - see previous description; core grade minimum
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=5 mg/kg/day; Systemic LEL=25 mg/kg/day (neuropathy; body weight loss); core grade minimum (Stauffer Chemical, 1984)
3) 1-Year Feeding - dog: NOEL=600 ppm (15 mg/kg/day); LEL=800 ppm (45 mg/kg/day) (decreased testes weight); core grade minimum (higher doses should have been used) (PPG Industries, 1986b)
4) Teratology - rat: Maternal/Fetal NOEL=100 mg/kg/day; Maternal/Fetal LEL=300 mg/kg/day (based on maternal mortality and reduced body weight gain; increased resorptions and fetal growth retardation; decreased fetal weight); Teratogenic NOEL=300 mg/kg/day; Teratogenic LEL=none; No effects at the LDT (30 mg/kg/day); core grade minimum (Stauffer Chemical, 1983)
5) Teratology - rabbit: Maternal NOEL=300 mg/kg/day; Maternal LEL=none; Fetotoxic NOEL=300 mg/kg/day; Fetotoxic LEL=none; core grade supplementary (PPG Industries, 1985)
Other Data Reviewed:
1) 2-Generation Reproduction - rat: Reported NOEL=200 ppm (10 mg/kg/day); Provisionally reported LEL=1000 ppm (50 mg/kg/day) (including decreased parental and F1 body and brain weight; decreased pup weight); No histopath- ology reported; core grade supplementary (Stauffer Chemical, 1982)
2) Subchronic Feeding - rat: NOEL=3 mg/kg/day (LDT); LEL=15 mg/kg/day (decreased body weight gains and food consumption); in HDT females only, depressed brain cholinesterase activity (PPG Industries, 1983)
Data Gap(s): Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Medium
RfD — Medium
The principal study is of adequate quality and is given a medium confidence rating. Since the database consists of core-minimum rated studies and a second chronic rat study is to be submitted, confidence in the database can be considered medium to high. Confidence in the RfD can also be considered medium to high.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Standard, September 1983
Pesticide Registration Files
Agency Work Group Review — 11/21/1985, 10/28/1986, 05/20/1987
Verification Date — 05/20/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for S-Ethyl dipropylthiocarbamate (EPTC) conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
Last Revised — 09/01/1990
_VI.A. Oral RfD References
PPG Industries, Inc. 1983. MRID No. 00144651. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
PPG Industries, Inc. 1985. MRID No. 00161599. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
PPG Industries, Inc. 1986a. MRID No. 00161597. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
PPG Industries, Inc. 1986b. MRID No. 00161595. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1982. MRID No. 001121284, 40420408. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1983. MRID No. 00138919. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1984. MRID No. 00145004. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
Date |
Section |
Description |
---|---|---|
09/01/1990 | I.A.4. | Citations added |
09/01/1990 | VI. | Bibliography on-line |
04/01/1997 | III., IV.,V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — S-Ethyl dipropylthiocarbamate (EPTC)
CASRN — 759-94-4
Last Revised — 09/30/1987
- 759-94-4
- CARBAMIC ACID, DIPROPYLTHIO-, S-ETHYL ESTER
- DIPROPYLCARBAMOTHIOIC ACID S-ETHYL ESTER
- EPTAM
- EPTC
- Ethyl dipropylthiocarbamate, S-
- ETHYL DI-n-PROPYLTHIOLCARBAMATE
- ETHYL-N,N-DIPROPYLTHIOLCARBAMATE
- ETHYL N,N-DI-n-PROPYLTHIOLCARBAMATE
- FDA 1541
- N,N-DIPROPYLTHIOCARBAMIC ACID S-ETHYL ESTER
- R-1608
- S-AETHYL-N,N-DIPROPYLTHIOLCARBAMAT
- S-Ethyl dipropylthiocarbamate
- S-ETHYL-N,N-DIPROPYLTHIOCARBAMATE
- S-ETHYL N,N-DI-n-PROPYLTHIOCARBAMATE