1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113) (CASRN 76-13-1)
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1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113);
CASRN 76-13-1
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR CFC-113
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on line | 02/01/1996 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 02/01/1996
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
NOTE: The Oral RfD for 1,1,2-trichloro-1,2,2-trifluoroethane may change in
the near future pending the outcome of a further review now being conducted by
the Oral RfD Work Group.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Psychomotor impairment Epidemiologic Study: Imbus and Adkins, 1972 |
NOAEL: 5358 mg/cu.m converted to 273 mg/kg/day |
10 |
1 |
3E+1 mg/kg/day |
*Conversion Factors: 10 cu.m/day (8-hour human breathing volume), 5 days/7 days, 0.5 absorption factor, 70 kg bw; thus, 5358 mg/cu.m x 10 cu.m/day x 5 days/7 days x 0.5/70 kg = 273 mg/kg/day
__I.A.2. Principal and Supporting Studies (Oral RfD)
Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to
trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261.
Several animal inhalation studies reported negative results in dogs, rabbits,
and rats chronically exposed to very high concentrations of
trichlorotrifluoroethane (U.S. EPA, 1983). No apparent adverse effects have
been reported in humans occupationally exposed to trichlorotrifluoroethane at
either 500 mg/cu.m levels for 11 years or 5358 mg/cu.m levels for 2.77 years
(Imbus and Adkins, 1972).
Slight impairment of psychomotor performance was reported in male volunteers
exposed to trichlorotrifluoroethane concentrations of 19,161 mg/cu.m for 2.75
hours (Stopps and McLaughlin, 1967). This exposure period was too brief to
consider a NOAEL for chronic exposure. Therefore, the RfD of 30 mg/kg/day is
considered protective.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — The uncertainty factor of 10 accounts for the expected interhuman
variability to the toxicity of this chemical in lieu of specific data.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
None.
__I.A.5. Confidence in the Oral RfD
Study — Low
Database — Low
RfD — Low
Confidence in the chosen study, database, and RfD are all considered low. Despite the fact that the chosen study describes human data and the fact that several chronic studies in animals are supportive, uncertainties in both the exposure levels and route extrapolation preclude higher confidence ratings.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Docuemnt -- U.S. EPA, 1983
Other EPA Documentation — None
Agency Work Group Review — 06/24/1985, 07/08/1985
Verification Date — 07/08/1985
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for 1,1,2-Trichloro-1,2,2-trifluoroethane conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 01/01/1990
_VI.A. Oral RfD References
Imbus, H.R. and C. Adkins. 1972. Physical examination of workers exposed to
trichlorotrifluoroethane. Arch. Environ. Health. 24(4): 257-261.
Stopps, G.J. and M. McLaughlin. 1967. Psychophysiological testing of human
subjects exposed to solvent vapors. Amer. Ind. Hyg. Assoc. J. 28: 43-50.
U.S. EPA. 1983. Health Assessment Document for 1,1,2-trichloro-1,2,2-
trifluoroethane (chlorofluorocarbon CFC 113). Office of Air Quality Planning
and Standards, Research Triangle Park, NC. EPA-600/8-82-002F. NTIS PB84-
118843. (Final Report)
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Date |
Section |
Description |
---|---|---|
04/06/1987 | I.A.1. | RfD corrected |
03/01/1988 | I.A.1. | Dose conversion factor corrected |
12/01/1988 | I.A. | RfD noted as pending change |
01/01/1990 | I.A.6. | Added U.S. EPA citation |
01/01/1990 | VI. | Bibliography on-line |
06/01/1990 | IV.A.1. | Area code for EPA contact corrected |
01/01/1992 | I.A.7. | Primary contact changed |
01/01/1992 | IV. | Regulatory actions updated |
04/01/1992 | IV.A.1. | CAA regulatory action withdrawn |
08/01/1995 | I.A. | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
02/01/1996 | I.A.7. | Contact changed |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — 1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)
CASRN — 76-13-1
Last Revised — 01/31/1987
- 76-13-1
- ARCTON 63
- ARKLONE P
- CFC-113
- DAIFLON S 3
- ETHANE, 1,1,2-TRICHLORO-1,2,2-TRIFLUORO-
- FLUOROCARBON 113
- FREON 113
- FREON 113TR-T
- FREON F113
- FREON TF
- FRIGEN 113a
- FRIGEN 113 TR-T
- GENETRON 113
- HALOCARBON 113
- ISCEON 113
- KHLADON 113
- R 113
- REFRIGERANT 113
- TRICHLOROTRIFLUOROETHANE
- 1,1,2-Trichloro-1,2,2-trifluoroethane
- Trichloro-1,2,2-trifluoroethane, 1,1,2-
- 1,1,2-TRIFLUORO-1,2,2- TRICHLOROETHANE
- UCON 113
- UCON 113/HALOCARBON 113
- UCON FLUOROCARBON 113