Molinate (CASRN 2212-67-1)
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0298
Molinate;
CASRN 2212-67-1
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Molinate
File First On-Line 09/26/1988
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 02/01/1991 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 02/01/1991
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Reproductive toxicity Rat Fertility Study Stauffer Chemical Co., |
NOEL: 0.2 mg/kg/day LEL: 4 mg/kg/day |
100
|
1
|
2E-3
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Stauffer Chemical Company. 1981. MRID No. 00079209. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Six groups of male Sprague-Dawley rats were administered technical grade molinate by corn oil gavage at 0, 0.2, 4, 12, 30, and 60 mg/kg/day. Samples were taken from each dose solution for concentration analysis and archival retention. There were no significant reductions in male or female fertility indices at 0.2 mg/kg/day, but there were considerable reductions including dose-related alterations in sperm morphology in both male and female indices at 4 mg/kg/day. The necropsy data for pregnant females indicated a significant reduction in the number of viable fetuses/litter as a result of matings in the 4 mg/kg/day group. An increase in the number of resorptions/ litter as a result of matings of untreated females with males in the 4 mg/kg/day dose group was also observed. Based on the above effects, the NOEL and LEL are 0.2 and 4 mg/kg/day, respectively.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences. An additional UF was not used to account for the lack of a long-term dog study since the 13-week studies showed that the dog is not likely to be more sensitive than the rat.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
- Fertility - rat: Principal study - see previous description; core grade supplementary
- 3-Generation Reproduction - rat: NOEL=0.63 mg/kg/day (HDT); core grade minimum (Stauffer Chemical Co., 1977a)
- 2-Year Feeding (oncogenic) - rat: Systemic NOEL=0.63 mg/kg/day; Systemic LEL=2 mg/kg/day (increase in organ weight); core grade minimum (Stauffer Chemical Co., 1977b)
- 13-Week Feeding - dog: NOEL=22.5 mg/kg/day; LEL=45 mg/gk/day (increased thyroid weight); no core grade (Stauffer Chemical Co., 1964a)
- 13-Week Feeding - rat: NOEL=8 mg/kg/day; LEL=16 mg/kg/day (ovarian vacuolation); no core grade (Stauffer Chemical Co., 1964b)
Data Gap(s): Chronic Dog Feeding Study, Rat Teratology Study, Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The critical study is of fair quality and is given a medium confidence rating. Since the database on chronic toxicity is poor, the database is given a low confidence rating. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA document.
Other EPA Documentation — Pesticide Registration Files
Agency Work Group Review — 09/16/1986, 04/15/1987, 03/23/1988
Verification Date — 03/23/1988
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Molinate conducted in November 2001 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 02/01/1991
_VI.A. Oral RfD References
Stauffer Chemical Company. 1964a. MRID No. 00092283. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1964b. MRID No. 00092282. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1977a. MRID No. 00054571. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1977b. MRID No. 00054570. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Stauffer Chemical Company. 1981. MRID No. 00079209. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Date |
Section |
Description |
---|---|---|
09/26/1988 | I.A. | Oral RfD summary on-line |
02/01/1991 | I.A. | Text edited |
02/01/1991 | VI. | Bibliography on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Molinate
CASRN — 2212-67-1
Primary Synonym — Ordram
Last Revised — 09/26/1988
- 2212-67-1
- 1H-azepine-1-carbothioic acid, hexahydro-, S-ethyl ester
- ethyl 1-hexamethyleneiminecarbothiolate
- felan
- hydram
- jalan
- Molinate
- molmate
- Ordram
- R-4572
- S-aethyl-N-hexahydro-1H-azepinthiolcarbamat
- S-ethyl hexahydro-1H-azepine-1-carbothioate
- S-ethyl 1-hexamethyleneiminothiocarbamate
- S-ethyl-N-hexamethylenethiocarbamate
- Stauffer R-4,572
- yalan
- yulan