Tribromodiphenyl ether (CASRN 49690-94-0)
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0492
Tribromodiphenyl ether; CASRN 49690-94-0
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR Tribromodiphenyl ether
File First On-Line 08/01/1990
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | on-line | 08/01/1990 |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Last Revised — 08/01/1990
Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a human carcinogen, and quantitative estimates of risk from oral exposure and from inhalation exposure. The quantitative risk estimates are presented in three ways. The slope factor is the result of application of a low-dose extrapolation procedure and is presented as the risk per (mg/kg)/day. The unit risk is the quantitative estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m air breathed. The third form in which risk is presented is a drinking water or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1 in 1,000,000. The rationale and methods used to develop the carcinogenicity information in IRIS are described in The Risk Assessment Guidelines of 1986 (EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries developed since the publication of EPA's more recent Proposed Guidelines for Carcinogen Risk Assessment also utilize those Guidelines where indicated (Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to Section I of this IRIS file for information on long-term toxic effects other than carcinogenicity.
_II.A. Evidence for Human Carcinogenicity
__II.A.1. Weight-of-Evidence Characterization
Classification — D; not classifiable as to human carcinogenicity
Basis — No human data and no animal data available.
__II.A.2. Human Carcinogenicity Data
None.
__II.A.3. Animal Carcinogenicity Data
None.
__II.A.4. Supporting Data for Carcinogenicity
Tribromodiphenyl ether is structurally-related to decabromodiphenyl ether, a possible human carcinogen.
_II.B. Quantitative Estimate of Carcinogenic Risk from Oral Exposure
None.
_II.C. Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure
None.
_II.D. EPA Documentation, Review, and Contacts (Carcinogenicity Assessment)
__II.D.1. EPA Documentation
Source Document — U.S. EPA, 1984
The 1984 Health and Environmental Effects Profile for Brominated Diphenyl Ethers has received Agency Review.
__II.D.2. EPA Review (Carcinogenicity Assessment)
Agency Work Group Review — 06/15/1990
Verification Date — 06/15/1990
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the cancer assessment for tribromodiphenyl ether conducted in August 2003 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.
__II.D.3. EPA Contacts (Carcinogenicity Assessment)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Last Revised — 08/01/1990
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
U.S. EPA. 1984. Health and Environmental Effects Profile for Brominated Diphenyl Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
_VII. Revision History
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Date |
Section |
Description |
---|---|---|
08/01/1990 | II. | Carcinogen assessment on-line |
08/01/1990 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
10/28/2003 | II.D.2 | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Tribromodiphenyl ether
CASRN — 49690-94-0
Last Revised — 08/01/1990
- 49690-94-0
- BENZENE, 1,1'-OXYBIS-, TRIBROMO DERIV.
- BENZENE, 1,1'-OXYBIS-, TRIBROMO DERIV.
- 1,1'-OXYBISBENZENE TRIBROMO DERIV.
- TRIBROMODIPHENYL ETHER
- TRIBROMODIPHENYL OXIDE
- TRIBROMOPHENOXYBENZENE