epsilon-Hexachlorocyclohexane (epsilon-HC) (CASRN 6108-10-7)
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0164
epsilon-Hexachlorocyclohexane (epsilon-HC);
CASRN 6108-10-7
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR epsilon-HC
File First On-Line 03/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | on-line | 07/01/1993 |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Last Revised — 07/01/1993
Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a human carcinogen, and quantitative estimates of risk from oral exposure and from inhalation exposure. The quantitative risk estimates are presented in three ways. The slope factor is the result of application of a low-dose extrapolation procedure and is presented as the risk per (mg/kg)/day. The unit risk is the quantitative estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m air breathed. The third form in which risk is presented is a drinking water or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1 in 1,000,000. The rationale and methods used to develop the carcinogenicity information in IRIS are described in The Risk Assessment Guidelines of 1986 (EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries developed since the publication of EPA's more recent Proposed Guidelines for Carcinogen Risk Assessment also utilize those Guidelines where indicated (Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to Section I of this IRIS file for information on long-term toxic effects other than carcinogenicity.
_II.A. Evidence for Human Carcinogenicity
__II.A.1. Weight-of-Evidence Characterization
Classification — D; not classifiable as to human carcinogenicity
__II.A.2. Human Carcinogenicity Data
None.
__II.A.3. Animal Carcinogenicity Data
Goto et al. (1972) observed increased incidence of benign and malignant hepatomas in ICR-JCL mice treated for 26 weeks with a mixture of delta- and epsilon-HCH. Individual isomers were not tested.
__II.A.4. Supporting Data for Carcinogenicity
epsilon-HCH is structurally related to carcinogenic HCH.
_II.B. Quantitative Estimate of Carcinogenic Risk from Oral Exposure
Not available
_II.C. Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure
Not available
_II.D. EPA Documentation, Review, and Contacts (Carcinogenicity Assessment)
__II.D.1. EPA Documentation
Source Document — U.S. EPA, 1986
The 1986 Health and Environmental Effects Profile has received an Agency review.
__II.D.2. EPA Review (Carcinogenicity Assessment)
Agency Work Group Review — 12/17/1986
Verification Date — 12/17/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the cancer assessment for epsilon-Hexachlorocyclohexane (epsilon-HC) conducted in August 2003 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.
__II.D.3. EPA Contacts (Carcinogenicity Assessment)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Last Revised — 09/01/1989
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
Goto, M., M. Hattori, T. Miyagawa and M. Enomoto. 1972. Ecological chemistry. II. Hepatoma formation in mice after administration of high doses of hexachlorocyclohexane isomers. Chemosphere. 1(6): 279-282.
U.S. EPA. 1986. Health and Environmental Effects Profile for Hexachlorocyclohexanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
_VII. Revision History
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Date |
Section |
Description |
---|---|---|
09/01/1989 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
07/01/1993 | II.D.3. | Secondary contact's phone number changed |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
10/28/2003 | II.D.2. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — epsilon-Hexachlorocyclohexane (epsilon-HC)
CASRN — 6108-10-7
Last Revised — 03/31/1987
- 6108-10-7
- Cyclohexane, 1,2,3,4,5,6-
- Cyclohexane, 1,2,3,4,5,6-hexachloro-, (1alpha,2alpha,3alpha,4beta,5beta,6beta)-
- epsilon-HC
- epsilon-HCH
- Hexachlorocyclohexane, epsilon-
- epsilon-1,2,3,4,5,6-Hexachlorocyclohexane