Bidrin (CASRN 141-66-2)
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0211
Bidrin;
CASRN 141-66-2
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Bidrin
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 11/01/1989 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Bidrin
CASRN — 141-66-2
Last Revised — 11/01/1989
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Decreased pup 3-Generation Rat Shell Chemical, 1965a |
NOEL: 2 ppm diet LEL: 5 ppm diet |
1000
|
1
|
1E-4
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Shell Chemical Company. 1965a. MRID No. 00013446, 00066340. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Bidrin was dissolved in water and mixed with powdered rat food to produce
concentrations of 2, 5, 15, and 50 ppm. The study was conducted in two parts.
In part one, weanling Long-Evans rats were assigned (10 males and 20 females)
to groups receiving 0, 5, 15, or 50 ppm bidrin. In part two, weanling Long-
Evans rats were assigned (10 males and 20 females) to groups receiving 0 and 2
ppm bidrin. Sections of brain, heart, lung, liver, spleen, pancreas, kidney,
and testes were preserved for histologic examination. Reproductive toxicity
(decreased pup survival) was observed at 5 ppm. Other effects (weakness,
emaciation, and CNS effects) were seen at 50 ppm. No effects were observed at
2 ppm.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 1000 was used to account for the inter- and
intraspecies differences, and to account for the fact that the chronic
toxicity database is incomplete.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 3-Generation Reproduction - rat: Principal study - see previous
description; core grade supplementary
2) 2-Year Feeding (oncogenic) - rat: ChE NOEL=none; ChE LEL=0.05 mg/kg/day
(plasma ChE inhibition); core grade supplementary; interim report (Shell
Chemical, 1967a)
3) 2-Year Feeding - dog ChE NOEL=0.04 mg/kg/day; ChE LEL=0.4 mg/kg/day (RCB
and plasma ChE inhibition); core grade supplementary; interim report (Shell
Chemical, 1967b)
4) Teratology - rat: Embryotoxic NOEL=2.5 mg/kg/day; Embryotoxic LEL=5
mg/kg/day (decreased implantation sites); core grade supplementary;
preliminary report (Shell Chemical, 1965b)
5) Teratology - rabbit: Maternal NOEL=4 mg/kg/day; Maternal LEL=8 mg/kg/day
(salivation and tremors); no core grade (Shell Chemical, 1973)
Data Gap(s): Chronic Rat Feeding Study; Chronic Dog Feeding Study; Rat
Reproduction Study; Rat Teratology Study; Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — Low
Database — Low
RfD — Low
The principal study is of low quality and is given a low confidence rating. Additional studies are also of low quality and, therefore, the database is given a low confidence rating. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Data Evaluation Record and Registration Standard
Agency Work Group Review — 08/19/1986, 09/02/1986
Verification Date — 08/19/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Bidrin conducted in September 2002 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Bidrin
CASRN — 141-66-2
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Bidrin
CASRN — 141-66-2
This substance/agent has not undergone a complete evaluation and determination
under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Bidrin
CASRN — 141-66-2
Last Revised — 11/01/1989
_VI.A. Oral RfD References
Shell Chemical Company. 1965a. MRID No. 00013446, 00066340. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1965b. MRID No. 00013447, 00141908. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1967a. MRID No. 00013563, 00013966. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1967b. MRID No. 00013564, 00013966. Available from
EPA. Write to FOI, EPA, Washington, DC 20460.
Shell Chemical Company. 1973. Accession No. 111367. Available from EPA.
Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Bidrin
CASRN — 141-66-2
Date |
Section |
Description |
---|---|---|
11/01/1989 | I.A. | Principal study year corrected |
11/01/1989 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory actions updated |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Bidrin
CASRN — 141-66-2
Last Revised — 09/30/1987
- 141-66-2
- BIDIRL
- Bidrin
- C 709
- CARBICRON
- CIBA 709
- cis-2-DIMETHYLCARBAMOYL-1-METHYLVINYL DIMETHYLPHOSPHATE
- cis-3-HYDROXY-N,N-DIMETHYLCROTONAMIDE
- CROTONAMIDE, 3-HYDROXY-N,N-DIMETHYL-, cis-, DIMETHYL PHOSPHATE
- CROTONAMIDE, 3-HYDROXY-N-N-DIMETHYL-, DIMETHYL PHOSPHATE, (E)-
- DIAPADRIN
- DICROTOFOS
- DICROTOPHOS
- 3-(DIMETHOXYPHOSPHINYLOXY)-N,N-DIMETHYL-cis-CROTONAMIDE
- 3-(DIMETHOXYPHOSPHINYLOXY)-N,N DIMETHYLISOCROTONAMIDE
- 3-(DIMETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL DIMETHYL PHOSPHATE
- DIMETHYLCARBAMOYL-1-METHYLVINYL DIMETHYLPHOSPHATE, cis-2-
- 2-DIMETHYL cis-2-DIMETHYL-CARBAMOYL-1-METHYLVINYL PHOSPHATE
- EKTAFOS
- ENT 24,482
- ESTER
- ESTER, (E)-
- 3-HYDROXYDIMETHYL CROTONAMIDE DIMETHYL PHOSPHATE
- HYDROXY-N,N-DIMETHYLCROTONAMIDE, cis-3-
- 3-HYDROXY-N,N-DIMETHYL-cis-CROTONAMIDE DIMETHYL PHOSPHATE
- O,O-DIMETHYL-O-(2-DIMETHYL-CARBAMOYL-1-METHYL-VINYL)PHOSPHAT
- O,O-DIMETHYL-O-(1,4-DIMETHYL-3-OXO-4-AZA-PENT-1-ENYL)FOSFAAT
- O,O-DIMETHYL-O-(1,4-DIMETHYL-3-OXO-4-AZA-PENT-1-ENYL)PHOSPHATE
- O,O-DIMETHYL-O-(1-METHYL-2-N,N-DIMETHYL-CARBAMOYL)-VINYL-PHOSPHAT
- O,O-DIMETHYL O-(N,N-DIMETHYLCARBAMOYL-1-METHYLVINYL)PHOSPHATE
- O,O-DIMETIL-O-(1,4-DIMETIL-3-OXO-4-AZA-PENT-1-ENIL)-FOSFATO
- PHOSPHATE DE DIMETHYLE ET DE 2-DIMETHYLCARBAMOYL 1-METHYL VINYLE
- PHOSPHORIC ACID 3-(DIMETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL DIMETHYL
- PHOSPHORIC ACID, DIMETHYL 1-METHYL-N,N-(DIMETHYLAMINO)-3-OXO-1-PROPENYL
- SD 3562
- SHELL SD-3562