Prometon (CASRN 1610-18-0)
view QuickView

0094
Prometon; CASRN 1610-18-0
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Prometon
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 01/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Prometon
CASRN — 1610-18-0
Last Revised — 01/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
No treatment related Subchronic Rat Ciba-Geigy, 1982a |
NOAEL: 300 ppm LOAEL: none |
1000 |
1 |
1.5E-2 mg/kg/day |
*Dose Conversion Factors & Assumptions: 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Ciba-Geigy Corporation. 1982a. MRID No. 00129985, 00148609; HED Doc. No. 003700, 004781. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Thirty Sprague-Dawley rats/sex/group were fed diets containing 0, 10, 50, 100, and 300 ppm technical-grade prometon (98% active ingredient) for 90 days. No treatment-related effects were demonstrated at levels up to 300 ppm (HDT).
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 1000 was used to account for the inter- and intraspecies differences and for the lack of a chronic study.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Although it appears that maternal toxicity (weight) was observed at 3.5 mg/kg/day in the teratology study, the use of this NOEL was not considered appropriate since the material was administered by gavage, maternal weight is a doubtful indicator in rabbits, and compound administration in teratology studies was of short but acute duration. Moreover, significant new studies are in progress, and the RfD should be reviewed once they are completed.
Data Considered for Establishing the RfD
1) 90-Day Feeding - rat: Principal study - see discussion above; core grade minimum
2) Teratology - rat: Maternal NOEL=120 mg/kg/day; Maternal LEL=360 mg/kg/day (decreased weight gain); Fetotoxic NOEL=360 mg/kg/day (HDT); core grade minimum (Ciba-Geigy, 1981)
3) Teratology - rabbit: Maternal NOEL=3.5 mg/kg/day; Maternal LEL=24.5 mg/kg/day (decreased weight); Fetotoxic NOEL=24.5 mg/kg/day (HDT); core grade minimum (Ciba-Geigy, 1982b)
4) 4-Week Feeding - dog: LEL=1000 ppm (25 mg/kg/day) (LDT) (reduced body weight gain); core grade supplementary (Ciba-Geigy, 1976a)
Data Gap(s): Chronic Rat Feeding Study; Chronic Dog Feeding Study; Rat Reproduction Study
Other Data Reviewed
1) 4-Week Feeding - rat: NOEL=600 ppm (30 mg/kg/day); LEL=1000 ppm (50 mg/kg/day) (reduced body gain); core grade supplementary (Ciba-Geigy, 1976b)
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The principal study appears to be of fair quality and is given a medium confidence rating. The database for prometon is lacking three important studies; therefore, the database is given a low confidence rating. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registation Files
Agency Work Group Review — 05/30/1986
Verification Date — 05/30/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Prometon conducted in September 2002 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Prometon
CASRN — 1610-18-0
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Prometon
CASRN — 1610-18-0
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Prometon
CASRN — 1610-18-0
Last Revised — 01/01/1992
_VI.A. Oral RfD References
Ciba-Geigy Corporation. 1976a. MRID No. 00054309; HED Doc. No. 000712. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Ciba-Geigy Corporation. 1976b. MRID No. 00054308; HED Doc. No. 000712. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Ciba-Geigy Corporation. 1981. MRID No. 00129983, 00148609; HED Doc. No. 003700, 004781. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Ciba-Geigy Corporation. 1982a. MRID No. 00129985, 00148609; HED Doc. No. 003700, 004781. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
Ciba-Geigy Corporation. 1982b. MRID No. 00129984, 00148609; HED Doc. No. 003700, 004781. Available from EPA. Write to FOI, EPA, Washington D.C. 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Prometon
CASRN — 1610-18-0
Date |
Section |
Description |
---|---|---|
03/01/1988 | I.A.1. | Dose conversion clarified |
01/01/1992 | I.A.4. | Citations added |
01/01/1992 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Prometon
CASRN — 1610-18-0
Last Revised — 01/31/1987
- 1610-18-0
- 2,4-BIS(ISOPROPYLAMINO)-6-METHOXY-s-TRIAZINE
- 2,6-DIISOPROPYLAMINO-4-METHOXYTRIAZINE
- G-31435
- GESAFRAM
- GESAFRAM 50
- 2-METHOXY-4,6-BIS(ISOPROPYLAMINO)-1,3,5-TRIAZINE
- 2-METHOXY-4,6-BIS(ISOPROPYLAMINO)-s-TRIAZINE
- METHOXYPROPAZINE
- ONTRACIC 800
- ONTRACK
- ONTRACK-WE-2
- PRAMITOL
- PRIMATOL
- PRIMATOL 25E
- Prometon
- PROMETONE
- s-TRIAZINE, 2,4-BIS(ISOPROPYLAMINO)-6-METHOXY-