Propargyl alcohol (CASRN 107-19-7)
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0468
Propargyl alcohol; CASRN 107-19-7
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR Propargyl alcohol
File First On-Line 11/01/1990
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 01/01/1994 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Propargyl alcohol
CASRN — 107-19-7
Last Revised — 01/01/1994
The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. It is expressed in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. Please refer to the Background Document for an elaboration of these concepts. RfDs can also be derived for the noncarcinogenic health effects of substances that are also carcinogens. Therefore, it is essential to refer to other sources of information concerning the carcinogenicity of this substance. If the U.S. EPA has evaluated this substance for potential human carcinogenicity, a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF
|
MF
|
RfD
|
---|---|---|---|---|
Renal and hepatotoxicity Rat Oral Subchronic U.S. EPA, 1987 |
NOAEL: 5 mg/kg/day LOAEL: 15 mg/kg/day |
3000
|
1
|
2E-3
mg/kg/day |
* Conversion Factors: Actual dose tested
__I.A.2. Principal and Supporting Studies (Oral RfD)
U.S. EPA. 1987. Rat oral subchronic toxicity study with propargyl alcohol. Study conducted by the Toxicity Research Laboratory for the Office of Solid Waste, Washington, DC.
Four groups of male and female rats (30/sex/group) were dosed orally with 0, 5, 15, and 50 mg/kg of propargyl alcohol daily for 13 weeks. The first 10 rats of each group were sacrificed on days 28-29 after dosing and the remaining rats were sacrificed on days 91 or 92 after dosing. Parameters examined included body and organ weight changes, food consumption, and hematological and histopathological evaluations. Treatment-related mortality was reported in the 50-mg/kg dosage group, although the precise cause was not identified. Hepatocytic megalocytosis with a less prominent proliferation of the bile ducts and cytoplasmic vacuolation of hepatocytes was observed in all rats in the 50 mg/kg group dosed for 1 or 3 months, in all 15 mg/kg rats dosed for 3 months, and in 9/10 males and 5/10 females dosed for 1 month. In the low-dose group, megalocytosis was seen only in one rat treated for 3 months. Karyomegaly of renal tubular epithelial cells was reported to occur in a dose- response fashion in the mid- and high-dose groups, but not in the low-dosage group. Hematological changes and some enzyme changes characteristic of liver damage were seen in the mid- and high-dose animals and were considered to be treatment-related. Treatment-related effects at the 15 mg/kg/day dose level included increased liver weights in both genders, increased kidney weights in females, and megalocytosis of the liver after 4 and 13 weeks of dosing; this dose is considered a LOAEL. The daily oral administration of 5 mg/kg of propargyl alcohol produced no apparent treatment-related effects and is considered the NOAEL for this study.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 3000 was used: 10 for interspecies conversion, 10 for intraspecies sensitivity differences, 10 for subchronic study use for chronic RfD derivation and 3 for the lack of toxicity data in a second species and reproductive/developmental studies.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
No other chronic, subchronic, or developmental/reproductive toxicity studies were found in the literature.
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The critical study identified both a NOAEL and a LOAEL for multiple endpoints and is considered to be of medium confidence. Confidence in the database is low due to the lack of supporting subchronic, chronic, and reproductive/developmental studies. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA document.
Other EPA Documentation — U.S. EPA, 1987
Agency Work Group Review — 02/21/1990
Verification Date — 02/21/1990
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Propargyl alcohol conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Propargyl alcohol
CASRN — 107-19-7
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Propargyl alcohol
CASRN — 107-19-7
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Propargyl alcohol
CASRN — 107-19-7
Last Revised — 01/01/1994
_VI.A. Oral RfD References
U.S. EPA. 1987. Rat oral subchronic toxicity study with propargyl alcohol. Study conducted by the Toxicity Research Laboratory for the Office of Solid Waste, Washington, DC.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Propargyl alcohol
CASRN — 107-19-7
Date |
Section |
Description |
---|---|---|
11/01/1990 | I.A. | Oral RfD summary on-line |
11/01/1990 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
07/01/1993 | I.A.6. | Other EPA Documentation added |
01/01/1994 | I.A.1. | Citation year changed to 1987 |
01/01/1994 | I.A.2. | Citation year changed to 1987 |
01/01/1994 | I.A.6. | Citation year changed to 1987 |
01/01/1994 | VI.A. | Reference year changed to 1987 |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Propargyl alcohol
CASRN — 107-19-7
Last Revised — 11/01/1990
- 107-19-7
- 2-Propyn-1-ol
- Ethynylcarbinol
- HSDB 6054
- METHANOL, ETHYNYL-
- NA 1986
- NSC 8804
- Propargyl alcohol
- PROPYNYL ALCOHOL
- RCRA WASTE NUMBER P102
- 1-HYDROXY-2-PROPYNE
- 1-propyn-3-ol
- 2-PROPYN-1-OL
- 2-PROPYNOL
- 2-PROPYNYL ALCOHOL
- 3-HYDROXY-1-PROPYNE
- 3-PROPYNOL