Maneb (CASRN 12427-38-2)
view QuickView

0249
Maneb;
CASRN 12427-38-2
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Maneb
File First On-Line 09/07/1988
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 01/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Maneb
CASRN — 12427-38-2
Last Revised — 01/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Increased thyroid 6-Month Monkey Rohm and Haas Co., |
NOEL: 5 mg/kg/day LEL: 15 mg/kg/day |
1000
|
1
|
5E-3 |
*Conversion Factors -- None
__I.A.2. Principal and Supporting Studies (Oral RfD)
Rohm and Haas Company. 1977. MRID No. 00129980; HED Doc. No. 004920. Maneb Data Task Force. 1986. MRID No. 00161552; HED Doc. No. 004920. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
Groups of 4 male and 4 female rhesus monkeys were fed 0, 100, 300, or 3000 ppm of technical maneb (90% active) for 6 months. At 3000 ppm treatment-related effects consisted of increased thyroid weights, reduced I131 uptake by the thyroid, and lower mean percentage of protein-bound I131. At 300 ppm increased thyroid weights were seen. The NOEL for systemic toxicity was established at 100 ppm, or 5 mg/kg/day.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — The UF of 1000 allows for uncertainty in the extrapolation of dose levels from laboratory animals to humans (10A) uncertainty in the threshold for sensitive humans (10H) and uncertainty in the effect of duration on toxicity when extrapolating from subchronic to chronic exposure.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Although a 1-year dog study showed effects at lower dose levels than the monkey study, the EPA felt that the dog study was not adequate for establishing an RfD because: mongrel dogs were used (source unknown), the age of the animal was not always specified (some were 10-12 years old), only one female dog was used (control group), food consumption data were not presented, and the animals were coprophagic.
Data Considered for Establishing the RfD:
1) 6-Month Feeding - monkey: Principal study - see previous description; core grade minimum
2) 1-Year Oral - dog: LEL=2 mg/kg/day (edema of spinal nerves with loss of myelin); core grade supplementary (duPont and Co., 1955a)
3) 31-Month Feeding - rat: NOEL=15 mg/kg/day; LEL=50 mg/kg/day (decreases in body weight, increases in mean absolute thyroid weight, an increased incidence of bladder epithelial dysplasia); core grade supplementary (Rohm and Haas Co., 1979)
4) 2-Year Feeding - rat: NOEL=12.5 mg/kg/day; LEL=125 mg/kg/day (nodule goiter and thyroid adenomas); core grade supplementary (duPont and Co., 1955b)
Data gap(s): Chronic Rat Feeding Study; Chronic Dog Feeding Study; Rat Teratology Study; Rabbit Teratology Study; Rat Reproduction Study
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The quality of the study used for calculating the RfD is good; therefore the study is given a medium confidence rating. Since extensive data gaps exist for maneb, the database and RfD are given low confidence ratings.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Standard, September 1986
Pesticide Registration Files
Agency Work Group Review — 12/02/1985, 09/17/1987, 10/14/1987
Verification Date — 10/14/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Maneb conducted in November 2001 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Maneb
CASRN — 12427-38-2
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Maneb
CASRN — 12427-38-2
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Maneb
CASRN — 12427-38-2
Last Revised — 01/01/1992
_VI.A. Oral RfD References
E.I. duPont de Nemours and Company, Inc. 1955a. MRID No. 00083292; HED Doc. No. 004806. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
E.I. duPont de Nemours and Company, Inc. 1955b. MRID No. 00083292; HED Doc. No. 004806. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
Maneb Data Task Force. 1986. MRID No. 00161552; HED Doc. No. 004920. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
Rohm and Haas Company. 1977. MRID No. 00129980; HED Doc. No. 004920. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
Rohm and Haas Company. 1979. MRID No. 00129979, 00130305, 401250101, 40559201; HED Doc. No. 004969. Available from U.S. EPA. Write to FOI, U.S. EPA Washington, DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Maneb
CASRN — 12427-38-2
Date |
Section |
Description |
---|---|---|
09/07/1988 | I.A. | Oral RfD summary on-line |
04/01/1991 | I.A. | Text edited |
01/01/1992 | I.A.4. | Citations added |
01/01/1992 | IV. | Regulatory Action section on-line |
01/01/1992 | VI. | Bibliography on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Maneb
CASRN — 12427-38-2
Last Revised — 09/07/1988
- 12427-38-2
- AAMANGAN
- AKZO CHEMIE MANEB
- BASF-MANEB SPRITZPULVER
- CARBAMIC ACID, ETHYLENEBIS(DITHIO-, MANGANESE SALT
- CHEM NEB
- CHLOROBLE M
- CR 3029
- DITHANE M 22
- DITHANE M 22 SPECIAL
- ENT 14,875
- 1,2-ETHANEDIYLBIS(CARBAMODITHIOATO)(2-)-MANGANESE
- 1,2-ETHANEDIYLBISCARBAMODITHIOIC ACID, MANGANESE(2+) SALT
- 1,2-ETHANEDIYLBISCARBAMODITHIOIC ACID, MANGANESE COMPLEX
- 1,2-ETHANEDIYLBISMANEB, MANGANESE (2+) SALT
- ETHYLENEBISDITHIOCARBAMATE MANGANESE
- ETHYLENEBIS(DITHIOCARBAMATO), MANGANESE
- ETHYLENEBIS(DITHIOCARBAMIC ACID), MANGANESE SALT
- ETHYLENEBIS(DITHIOCARBAMIC ACID) MANGANOUS SALT
- 1,2-ETHYLENEDIYLBIS(CARBAMODITHIOATO)MANGANESE
- F 10
- GRIFFIN MANEX
- KYPMAN 80
- LONOCOL M
- MANAM
- Maneb
- MANEB 80
- MANEBA
- MANEBE
- MANEBE 80
- MANEBGAN
- MANEB ZL4
- MANESAN
- MANEX
- MANGAAN (II)-(N,N'-ETHYLEEN-BIS(DITHIOCARBAMAAT))
- MANGANESE ETHYLENE BIS-DITHIOCARBAMATE
- MANGANESE ETHYLENE-1,2-BISDITHIOCARBAMATE
- MANGANESE, (ETHYLENEBIS(DITHIOCARBAMATO))-
- MANGANESE (II) ETHYLENE DI(DITHIOCARBAMATE)
- MANGAN(II)-(N,N-AETHYLEN-BIS(DITHIOCARBAMAT)
- MANGAN (II)-(N,N'-AETHYLEN-BIS(DITHIOCARBAMATE))
- MANGANOUS ETHYLENEBIS(DITHIOCARBAMATE)
- MANZATE
- MANZATE 200
- MANZATE D
- MANZATE MANEB FUNGICIDE
- MANZEB
- MANZIN
- M-DIPHAR
- MEB
- MnEBD
- NEREB
- NESPOR
- N,N'-ETHYLENE BIS(DITHIOCARBAMATE MANGANEUX)
- N,N'-ETILEN-BIS(DITIOCARBAMMATO) DI MANGANESE
- PLANTIFOG 160M
- POLYRAM M
- REMASAN CHLOROBLE M
- RHODIANEBE
- SOPRANEBE
- SUP 'R FLO
- TERSAN-LSR
- TRIMANGOL
- TRIMANGOL 80
- TUBOTHANE
- UN 2210
- UN 2968
- UNICROP MANEB
- VANCIDE MANEB 80