Propylene glycol monoethyl ether (CASRN 52125-53-8)
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0544
Propylene glycol monoethyl ether;
CASRN 52125-53-8
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Propylene glycol monoethyl ether
File First On-Line 06/01/1991
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | |
Inhalation RfC Assessment (I.B.) | message | 06/01/1991* |
Carcinogenicity Assessment (II.) | no data |
*A comprehensive review of toxicological studies was completed 01/07/05 - please see section I.B for more information.
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Propylene glycol monoethyl ether
CASRN — 52125-53-8
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Propylene glycol monoethyl ether
CASRN — 52125-53-8
The health effects data for propylene glycol monoethyl ether were reviewed by the U.S. EPA RfD/RfC Work Group and determined to be inadequate for the derivation of an inhalation RfC. The verification status of this chemical is currently not verifiable. For additional information on the health effects of this chemical, interested parties are referred to the EPA documentation listed below.
U.S. EPA. 1984. Health Effects Assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. NTIS PB-86-134632/AS.
Agency Work Group Review — 04/25/1991
A comprehensive review of toxicological studies published through 2004 indicated that there is insufficient health effects data to derive an RfC for Propylene glycol monoethyl ether at this time. For more information, IRIS users may contact the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
EPA Contacts:
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Propylene glycol monoethyl
ether
CASRN — 52125-53-8
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Propylene glycol monoethyl ether
CASRN — 52125-53-8
Last Revised — 06/01/1991
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
U.S. EPA. 1984. Health Effects Assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. NTIS PB-86-134632/AS.
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Propylene glycol monoethyl ether
CASRN — 52125-53-8
Date |
Section |
Description |
---|---|---|
06/01/1991 | I.B. | Inhalation RfC message on-line |
06/01/1991 | VI. | Bibliography on-line |
04/01/1997 | III. ,IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.B. | Screening-Level Literature Review Findings message has been added. |
03/03/2005 | I.B. | Screening-Level Literature Review Findings message has been removed and replaced by comprehensive literature review conclusions. |
_VIII. Synonyms
Substance Name — Propylene glycol monoethyl ether
CASRN — 52125-53-8
Last Revised — 06/01/1991
- 52125-53-8
- PROPANOL, ETHOXY-
- 1,2-PROPANEDIOL, MONOETHYL ETHER
- ETHOXY-PROPANOL
- ETHYL ETHER OF PROPYLENE GLYCOL
- PROPYLENE GLYCOL MONOETHYL ETHER