Baygon (CASRN 114-26-1)
view QuickView

0210
Baygon;
CASRN 114-26-1
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Baygon
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 07/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Baygon
CASRN — 114-26-1
Last Revised — 07/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Mild cholinergic Single-Dose Human Vandkar et al., 1971 |
NOEL: None LEL: 0.36 mg/kg/day |
100
|
1
|
4E-3
mg/kg/day |
*Conversion Factors: none
__I.A.2. Principal and Supporting Studies (Oral RfD)
Vandekar, M., R. Plestina and K. Wilhelm. 1971. Toxicity of carbamates for
mammals. Bull. World. Health. Org. 44: 241-249.
An unspecified number of human volunteers received a single oral dose of 0.36
mg/kg baygon. This single dose caused mild cholinergic signs and 43%
inhibition of red blood cell cholinesterase in 10 minutes.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the differences of
sensitivity in the human population and to account for the fact that effects
were observed at 0.36 mg/kg/day.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) Oral Dosages - human: Principal study - see previous description; core
grade supplementary
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=200 ppm (10 mg/kg/day);
Systemic LEL=1000 ppm (50 mg/kg/day) (weight depression, increased incidence
of urothelial hyperplasia of the bladder, slight increase in neuropathy); core
grade minimum (Mobay Chemical, 1984a)
3) 12-Month Feeding - dog: NOEL=200 ppm (5 mg/kg/day); LEL=600 ppm (15
mg/kg/day) (increased mean liver weight and N-demethylase activity, increased
plasma cholesterol); ChE NOEL=none; ChE LEL=200 ppm; core grade supplementary
(Mobay Chemical, 1984b)
4) 3-Generation Reproduction - rat: Reproductive NOEL=250 ppm (12.5
mg/kg/day); Reproductive LEL=750 ppm (37.5 mg/kg/day) (decreased pup number);
no core grade (Mobay Chemical, 1968)
5) Teratology - rat: Maternal NOEL=1000 ppm (50 mg/kg/day); Maternal LEL=3000
ppm (150 mg/kg/day) (body weight gain and food consumption decreased);
Fetotoxic NOEL=1000 ppm (50 mg/kg/day); Fetotoxic LEL=3000 ppm (150 mg/kg/day)
(average weight of fetus significantly lower); Teratogenic NOEL=10,000 ppm
(500 mg/kg/day) (HDT); Teratogenic LEL=none; no core grade (Chemagro Corp.,
1971)
6) Teratology - rabbit: Maternal NOEL=10 mg/kg/day (HDT); Maternal LEL=none;
Fetotoxic NOEL=10 mg/kg/day (HDT); Fetotoxic LEL=none; Teratogenic NOEL=10
mg/kg/day (HDT); Teratogenic LEL=none; core grade minimum (Mobay Chemical,
1981a)
Other Data Reviewed:
1) 2-Year Feeding (oncogenic) - mice: Systemic NOEL=700 ppm (105 mg/kg/day);
Systemic LEL=2000 ppm (300 mg/kg/day); core grade minimum (Mobay Chemical,
1981b)
2) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=250 ppm (12.5 mg/kg/day);
Systemic LEL=750 ppm (increased liver weight), ChE not established (because of
lack of method); core grade supplementary for oncogenicity (pathology reported
for only 5 rats/sex/group) (Chemagro Corp., 1976)
3) 2-Year Feeding - dog: NOEL=250 ppm (6.25 mg/kg/day); LEL=750 ppm (18.75
mg/kg/day) (decreased body weight; food consumption; increased liver weight);
ChE NOEL not established because of lack of method; no core grade (Chemagro
Corp., 1968)
Data Gap(s): Short-term dog study measuring ChE depression
__I.A.5. Confidence in the Oral RfD
Study — Low
Database — Medium
RfD — Medium
The critical study appears to be of poor quality and is given a low confidence rating. Additional studies are of adequate quality and, therefore, the data base is given a medium confidence rating. Medium confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Files
Agency Work Group Review — 12/09/1986, 02/18/1987
Verification Date — 02/18/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Baygon conducted in August 2003 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or 202-566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this ssessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Baygon
CASRN — 114-26-1
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Baygon
CASRN — 114-26-1
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Baygon
CASRN — 114-26-1
Last Revised — 10/01/1990
_VI.A. Oral RfD References
Chemagro Corporation. 1968. MRID No. 00035423. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Chemagro Corporation. 1971. MRID No. 00045094. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Chemagro Corporation. 1976. MRID No. 00035425, 00070673. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1968. MRID No. 00052277, 00055142. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1981a. MRID No. 00100547. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1981b. MRID No. 00100546, 00138815. Available from
EPA. Write to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1984a. MRID No. 0014275. Available from EPA. Write
to FOI, EPA, Washington DC 20460.
Mobay Chemical Company. 1984b. MRID No. 00149040. Available from EPA.
Write to FOI, EPA, Washington DC 20460.
Vandekar, M., R. Plestina and K. Wilhelm. 1971. Toxicity of carbamates for
mammals. Bull. World. Health. Org. 44: 241-249.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Baygon
CASRN — 114-26-1
Date |
Section |
Description |
---|---|---|
03/31/1987 | I.A.6. | Documentation corrected |
03/31/1987 | IV.A. | Pesticide AI data added |
11/01/1989 | VI. | Bibliography on-line |
10/01/1990 | III.A. | Health Advisory on-line |
10/01/1990 | VI.D. | Health Advisory references added |
01/01/1992 | IV. | Regulatory action updated |
07/01/1992 | I.A.4. | Study 5) citation corrected |
04/01/1997 | III., IV., V., VI.D. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
10/28/2003 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Baygon
CASRN — 114-26-1
Last Revised — 09/30/1987
- 114-26-1
- APROCARB
- ARPROCARB
- BAY 39007
- BAY 9010
- BAYER 39007
- Baygon
- BIFEX
- BLATTANEX
- BOYGON
- BRYGOU
- CARBAMIC ACID, METHYL-, 2-(1-METHYLETHOXY)PHENYL ESTER
- CHEMAGRO 9010
- ENT 25,671
- HYDROXY-N,N-DIMETHYLCROTONAMIDE
- o-IMPC
- INVISI-GARD
- ISOCARB
- 2-ISOPROPOXYPHENYL METHYLCARBAMATE
- o-ISOPROPOXYPHENYL METHYLCARBAMATE
- 2-ISOPROPOXYPHENYL-N-METHYLCARBAMAT
- 2-ISOPROPOXYPHENYL N-METHYLCARBAMATE
- o-ISOPROPOXYPHENYL N-METHYLCARBAMATE
- 2-(1-METHYLETHOXY)PHENOL METHYLCARBAMATE
- N-METHYL-2-ISOPROPOXYPHENYLCARBAMATE
- OMS-33
- PHC
- PHENOL, o-ISOPROPOXY-, METHYLCARBAMATE
- PROPOKSURU
- PROPOTOX M
- PROPOXUR
- PROPOXURE
- PROPYON
- SENDRAN
- SUNCIDE
- TUGON FLIEGENKUGEL
- UNDEN