1,3-Dichlorobenzene (CASRN 541-73-1)
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0447
1,3-Dichlorobenzene; CASRN 541-73-1
Health assessment information on a chemical substance is included in IRIS only after a comprehensive review of chronic toxicity data by U.S. EPA health scientists from several Program Offices and the Office of Research and Development. The summaries presented in Sections I and II represent a consensus reached in the review process. Background information and explanations of the methods used to derive the values given in IRIS are provided in the Background Documents.
STATUS OF DATA FOR 1,3-Dichlorobenzene
File First On-Line 09/01/1990
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | no data | 08/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | on-line | 09/01/1990 |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Not available at this time.
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Last Revised — 09/01/1990
Section II provides information on three aspects of the carcinogenic assessment for the substance in question; the weight-of-evidence judgment of the likelihood that the substance is a human carcinogen, and quantitative estimates of risk from oral exposure and from inhalation exposure. The quantitative risk estimates are presented in three ways. The slope factor is the result of application of a low-dose extrapolation procedure and is presented as the risk per (mg/kg)/day. The unit risk is the quantitative estimate in terms of either risk per ug/L drinking water or risk per ug/cu.m air breathed. The third form in which risk is presented is a drinking water or air concentration providing cancer risks of 1 in 10,000, 1 in 100,000 or 1 in 1,000,000. The rationale and methods used to develop the carcinogenicity information in IRIS are described in The Risk Assessment Guidelines of 1986 (EPA/600/8-87/045) and in the IRIS Background Document. IRIS summaries developed since the publication of EPA's more recent Proposed Guidelines for Carcinogen Risk Assessment also utilize those Guidelines where indicated (Federal Register 61(79):17960-18011, April 23, 1996). Users are referred to Section I of this IRIS file for information on long-term toxic effects other than carcinogenicity.
_II.A. Evidence for Human Carcinogenicity
__II.A.1. Weight-of-Evidence Characterization
Classification — D; not classifiable as to human carcinogenicity
Basis — Based on no human data, no animal data and limited genetic data.
__II.A.2. Human Carcinogenicity Data
None.
__II.A.3. Animal Carcinogenicity Data
None.
__II.A.4. Supporting Data for Carcinogenicity
An increase in the number of revertants of an auxotrophic strain of Aspergillus nidulans occurred when spores were treated with 1,3- dichlorobenzene (concentration and length of treatment not stated). The spontaneous reversion frequency of the strain was 3/100,000 and the reversion frequency of treated spores 11/100,000; this increase was not statistically significant (Prasad and Pramer, 1968).
_II.B. Quantitative Estimate of Carcinogenic Risk from Oral Exposure
None.
_II.C. Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure
None.
_II.D. EPA Documentation, Review, and Contacts (Carcinogenicity Assessment)
__II.D.1. EPA Documentation
Source Document — U.S. EPA, 1985
The 1985 Health Assessment Document for Chlorinated Benzenes has received Agency Review and approval for publication.
__II.D.2. EPA Review (Carcinogenicity Assessment)
Agency Work Group Review — 12/06/1989
Verification Date — 12/06/1989
__II.D.3. EPA Contacts (Carcinogenicity Assessment)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Last Revised — 09/01/1990
_VI.A. Oral RfD References
None
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
Prasad, I. and D. Pramer. 1968. Mutagenic activity of some chloranilines and chlorobenzenes. Genetics. 60: 212-213. (Abstr.)
U.S. EPA. 1985. Health Assessment Document for Chlorinated Benzenes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Solid Waste and Emergency Response, Washington, DC.
_VII. Revision History
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Date |
Section |
Description |
---|---|---|
09/01/1990 | II. | Carcinogen assesment on-line |
09/01/1990 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
08/01/1992 | I.A. | Oral RfD now under review |
08/01/1995 | I.A. | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
01/12/2000 | I., II. | This chemical is being reassessed under the IRIS Program. |
_VIII. Synonyms
Substance Name — 1,3-Dichlorobenzene
CASRN — 541-73-1
Last Revised — 09/01/1990
- 541-73-1
- BENZENE, 1,3-DICHLORO-
- BENZENE, M-DICHLORO-
- 1,3-DICHLOROBENZENE
- M-DICHLOROBENZENE
- M-DICHLOROBENZOL
- HSDB 522
- M-PHENYLENE DICHLORIDE
- NSC 8754