Picloram (CASRN 1918-02-1)
view QuickView

0256
Picloram;
CASRN 1918-02-1
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Picloram
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 05/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Picloram
CASRN — 1918-02-1
Last Revised — 05/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Increased liver 6-Month Dog Feeding Dow Chemical, 1982a |
NOEL: 7 mg/kg/day LEL: 35 mg/kg/day |
100
|
1
|
7E-2
mg/kg/day |
*Conversion Factors and Assumptions — none
__I.A.2. Principal and Supporting Studies (Oral RfD)
Dow Chemical Company. 1982a. MRID No. 000110534, 00110535; HED Doc. No. 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Male and female dogs (6/sex/group) were fed diets containing 0, 7, 35, or 175 mg/kg/day of picloram. The observed effects included reduced food consumption and body weight at 175 mg/kg/day for male and female dogs. Also, liver effects were experienced at 35 mg/kg/day for males (increased absolute and relative liver weights) and at 175 mg/kg/day for both males and females (increased absolute and relative liver weights and elevated serum alkaline phosphatase).
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the inter- and intraspecies differences.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD:
1) 6-Month Feeding - dog: Principal study - see previous description; core grade minimum
2) 2-Year Feeding - rat: NOEL=20 mg/kg/day; LEL=60 mg/kg/day (toxic changes in liver (histopathology); core grade guideline (Dow Chemical, 1986)
3) 90-Day Feeding - rat: NOEL=1000 ppm (50 mg/kg/day); LEL=3000 ppm (150 mg/kg/day)(liver histopathology, necrosis, and bile duct proliferation); core grade minimum (Dow Chemical, 1962)
4) 3-Generation Reproduction - rat: NOEL=1000 ppm (50 mg/kg/day); LEL=3000 ppm (150 mg/kg/day) (reduced fertility); core grade supplementary (Dow Chemical, 1967)
5) Teratology - rat: Teratagenic NOEL=1000 mg/kg/day (HDT); LEL=none; Fetotoxic NOEL=none; core grade minimum (Dow Chemical, 1972)
Other Data Reviewed:
1) 13-Week Feeding - rat: NOEL=50 mg/kg/day (liver effects at 150, 300 or 500 mg/kg/day, slight kidney enlargement at 300 or 500 mg/kg/day); core grade minimum (Dow Chemical, 1982b)
Data Gap(s): Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Medium
RfD — Medium
The principal study appears to be of fair quality and, therefore, is given a medium confidence rating. The database is of fair to good quality with one data gap and is given a medium confidence rating. Medium confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Standard, February, 1984
Agency Work Group Review — 05/30/1986, 04/15/1987
Verification Date — 04/15/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Picloram conducted in September 2002 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Picloram
CASRN — 1918-02-1
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Picloram
CASRN — 1918-02-1
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Picloram
CASRN — 1918-02-1
Last Revised — 10/01/1992
_VI.A. Oral RfD References
Dow Chemical Company. 1962. MRID No. 00041093, 00069969, 00072318, 00072320; HED Doc. No. 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Dow Chemical Company. 1967. MRID No. 000410984; HED Doc. No. 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Dow Chemical Company. 1972. MRID No. 00059417; HED Doc. No. 003177, 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Dow Chemical Company. 1982a. MRID No. 000110534, 00110535; HED Doc. No. 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Dow Chemical Company. 1982b. MRID No. 000110537; HED Doc. No. 003954. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Dow Chemical U.S.A. 1986. MRID No. 00155940. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Picloram
CASRN — 1918-02-1
Date |
Section |
Description |
---|---|---|
01/01/1992 | IV. | Regulatory actions updated |
05/01/1992 | I.A.4. | Citations added |
05/01/1992 | I.A.7. | Primary contact changed |
05/01/1992 | VI.A. | Bibliography on-line |
07/01/1992 | III.A. | Health Advisory on-line |
07/01/1992 | VI.D. | Health Advisory references on-line |
10/01/1992 | VI.D. | MRID No. corrected |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Picloram
CASRN — 1918-02-1
Last Revised — 09/30/1987
- 1918-02-1
- AMDON GRAZON
- 4-AMINO-3,5,6-TRICHLOROPICOLINIC ACID
- 4-AMINO-3,5,6-TRICHLORO-2-PICOLINIC ACID
- 4-AMINO-3,5,6-TRICHLORPICOLINSAEURE
- ATCP
- BOROLIN
- CHLORAMP
- K-PIN
- NCI-C00237
- Picloram
- PICOLINIC ACID, 4-AMINO-3,5,6-TRICHLORO-
- TORDON 10K
- TORDON 22K
- 3,5,6-TRICHLORO-4-AMINOPICOLINIC ACID