Glufosinate-ammonium (CASRN 77182-82-2)
view QuickView

0247
Glufosinate-ammonium;
CASRN 77182-82-2
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Glufosinate-ammonium
File First On-Line 09/30/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 05/01/1992 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
Last Revised — 05/01/1992
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
NOTE: The Oral RfD for glufosinate-ammonium may change in the near future pending the outcome of a further review now being conducted by the RfD/RfC Work Group.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Increased absolute 13-Week Rat Feeding Hoescht AG, 1982a |
NOEL: 8 ppm diet LEL: 64 ppm diet |
1000
|
1
|
4E-4
mg/kg/day |
*Conversion Factors -- 1 ppm = 0.05 mg/kg/day (assumed rat food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Hoescht AG. 1982a. MRID No. 00142443. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Twenty rats/sex/dose were fed diets containing 0, 8, 64, 500 or 4000 ppm of HOE 39866 (monoammonium 2-amino-4-[hydroxymethylphosphinyl]butanoate) for 13 weeks. An additional 10 rats/sex/dose were similarly treated, but were allowed a 4-week recovery period. An increase in absolute and relative kidney weights was noted in males treated with 64 ppm and above.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for intra- and interspecies differences in sensitivity. An additional factor of 10 was used because the study was only of 90 days duration.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
The 90-day feeding study using dogs (NOEL = 16 ppm, equivalent to 0.4 mg/kg/day) is considered as co-principal.
Data Considered for Establishing the RfD:
1) 13-Week Feeding - rat: Principal study - see previous description; core grade minimum
2) 90-Day Feeding - dog: NOEL=16 ppm (0.4 mg/kg/day); LEL=64 ppm (1.6 mg/kg/day) (decreased weight gain, decreased absolute and relative thyroid weights in females); core grade minimum (Hoechst AG, 1982b)
3) Teratology - rat: Developmental NOEL=2.24 mg/kg/day; LEL=10 mg/kg/day (dilated renal pelvis and hydroureter); Maternal NOEL=2.24 mg/kg/day; LEL=10 mg/kg/day (hyperactivity); core grade minimum (Hoechst AG, 1985a)
4) Teratology - rat: Developmental NOEL = none; LEL=10 mg/kg/day (dilated renal pelvis and hydroureter); Maternal NOEL=none; LEL=10 mg/kg/day (hyperactivity); core grade supplementary (Hoechst AG, 1985b)
Data Gap(s): Chronic Dog Feeding Study; Chronic Rat Feeding Study; Rat Reproduction Study; Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — High
Database — Medium
RfD — Medium
The principal study is of good quality and is given a high confidence rating. Since the database on chronic toxicity and reproduction is incomplete, confidence in the database can be considered medium to low. Confidence in the RfD can also be considered medium to low.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA document.
Other EPA Documentation — Pesticide Registration files
Agency Work Group Review — 02/18/1987
Verification Date — 02/18/1987
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Glufosinate-ammonium conducted in November 2001 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
Last Revised — 09/01/1990
_VI.A. Oral RfD References
Hoescht AG. 1982a. MRID No. 00142443. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Hoescht AG. 1982b. MRID No. 00149239. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Hoescht AG. 1985a. MRID No. 00151499. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Hoescht AG. 1985b. MRID No. 00151500. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfD References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
Date |
Section |
Description |
---|---|---|
09/01/1990 | I.A. | Principal study citation year corrected |
09/01/1990 | I.A.4. | Citations added |
09/01/1990 | VI. | Bibliography on-line |
05/01/1992 | I.A. | Oral RfD summary noted as pending change |
08/01/1995 | I.A. | EPA's RfD/RfC and CRAVE workgroups were discontinued in May, 1995. Chemical substance reviews that were not completed by September 1995 were taken out of IRIS review. The IRIS Pilot Program replaced the workgroup functions beginning in September, 1995. |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Glufosinate-ammonium
CASRN — 77182-82-2
Primary Synonym — Hoe 39866
Last Revised — 09/30/1987
- 77182-82-2
- Basta
- Caswell No. 580I
- EPA Pesticide Chemical Code 128850
- Glufosinate-ammonium
- HOE 00661
- Hoe 39866
- Monoammonium-2-amino-4-(hydroxymethylphosphinyl)butanoate