Phenylmercuric acetate (CASRN 62-38-4)
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0089
Phenylmercuric acetate;
CASRN 62-38-4
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Phenylmercuric acetate
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 11/01/1996 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
Last Revised — 11/01/1996
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Renal damage Fitzhugh et al., 1950 |
NOAEL: 0.1 ppm mercury LOAEL: 0.5 ppm mercury |
100 |
1 |
8E-5 mg/kg/day |
*Conversion Factors: Food consumption 5% bw/day, molecular weight phenyl mercuric acetate/mercury is 337/201; thus, 0.1 mg/kg of diet (ppm) x 0.05 kg of diet/kg bw/day x 337/201 = 0.0084 mg/kg bw/day
__I.A.2. Principal and Supporting Studies (Oral RfD)
Fitzhugh, O.G, A.A. Nelson, E.P. Laug and I.M. Kunze. 1950. Chronic oral
toxicities of mercuric phenyl and mercuric salts. Arch. Ind. Hyg. Occup. Med.
2: 433-442.
Phenyl mercuric acetate was administered to rats (10-24/group/sex) at levels
of 0, 0.1, 0.5, 2.5, 10, 40, and 160 mercury in their diet for 2 years.
Detailed microscopic examinations of the liver and kidney were performed at 1
and 2 years of age. Microscopic examination of the viscera was also performed
at the 2-year mark. As little as 0.5 ppm mercury as phenyl mercuric acetate
resulted in detectable kidney damage in females after 2 years. No differences
were seen between controls and females receiving 0.1 ppm mercury. At higher
doses (>2.5 ppm), renal lesions were observed in both males and females. A
NOEL of 0.1 ppm was determined from these results.
Fitzhugh et al. (1950) is the only chronic study regarding the oral toxicity
of phenyl mercuric acetate. Therefore, assuming that the rat consumed the
equivalent of 5% of its body weight in food/day, the 0.1 ppm Hg NOEL is
equivalent to 0.005 mg/kg/day Hg or 0.0084 mg/kg bw phenyl mercuric acetate.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An ADI of 0.08 ug/kg/day or 6 ug/kg/day for a 70-kg person was derived
by dividing the NOEL by an uncertainty factor of 100 to account for species
extrapolation and differences in human sensitivity.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
The database contains very little information on the oral toxicity of phenyl mercuric acetate. Some subchronic testing has been conducted. Limited data are available on the and teratogenic effects of this compound.
__I.A.5. Confidence in the Oral RfD
Study — Medium
Database — Low
RfD — Low
The chosen study is given a medium confidence rating because a moderate number of animals/sex were tested at each of six doses; several parameters were measured. The database is given a low confidence rating because little or no supporting data exist. Low confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Source Document — This assessment is not presented in any existing U.S. EPA
document.
Other EPA Documentation — None
Agency Work Group Review — 08/19/1985
Verification Date — 08/19/1985
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Phenylmercuric acetate conducted in September 2002 did not identify any critical new studies. IRIS users who know of important new studies may provide that information to the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
This substance/agent has not undergone a complete evaluation and determination under US EPA's IRIS program for evidence of human carcinogenic potential.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
Last Revised — 09/01/1989
_VI.A. Oral RfD References
Fitzhugh, O.G, A.A. Nelson, E.P. Laug and I.M. Kunze. 1950. Chronic oral toxicities of mercuric phenyl and mercuric salts. Arch. Ind. Hyg. Occup. Med. 2: 433-442.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
Date |
Section |
Description |
---|---|---|
04/10/1987 | I.A.1. | RfD exponent corrected |
03/01/1988 | I.A.5. | Confidence levels revised |
09/01/1989 | VI. | Bibliography on-line |
05/01/1991 | I.A.4. | Text edited |
01/01/1992 | I.A.7. | Primary contact changed |
01/01/1992 | IV. | Regulatory actions updated |
11/01/1996 | I.A.7. | Secondary contact's office changed |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Phenylmercuric acetate
CASRN — 62-38-4
Last Revised — 01/31/1987
- 62-38-4
- (Acetoxymercuri)Benzene
- Acetoxyphenylmercury
- Agrosan GN 5
- Algimycin
- Antimucin WDR
- Bufen
- Ceresan Universal
- Contra Creme
- Dyanacide
- Femma
- FMA
- Fungitox OR
- Gallotox
- HL-331
- Hostaquick
- Kwiksan
- Leytosan
- Liquiphene
- Mercury,(Acetato-O)Phenyl-
- Mercury, (Acetato)Phenyl-
- Mercury(II) Acetate, Phenyl-
- Mersolite
- Mersolite 8
- Metasol 30
- Norforms
- Phenmad
- Phenomercuric Acetate
- Phenylmercuriacetate
- Phenylmercuric Acetate
- Phix
- PMA
- PMAC
- PMacetate
- PMAL
- PMAS
- Programin
- Purasan-SC-10
- Puraturf 10
- Quicksan 20
- Sanitized SPG
- SC-110
- Shimmerex
- Spor-Kil
- TAG
- Trigosan
- Ziarnik