Oxyfluorfen (CASRN 42874-03-3)
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0084
Oxyfluorfen;
CASRN 42874-03-3
Health assessment information on a chemical substance is included in IRIS
only after a comprehensive review of chronic toxicity data by U.S. EPA
health scientists from several Program Offices and the Office of Research
and Development. The summaries presented in Sections I and II represent
a consensus reached in the review process. Background information and
explanations of the methods used to derive the values given in IRIS are
provided in the Background Documents.
STATUS OF DATA FOR Oxyfluorfen
File First On-Line 01/31/1987
Category (section) |
Status |
Last Revised |
---|---|---|
Oral RfD Assessment (I.A.) | on-line | 03/01/1991 |
Inhalation RfC Assessment (I.B.) | no data | |
Carcinogenicity Assessment (II.) | no data |
_I. Chronic Health Hazard Assessments for Noncarcinogenic Effects
_I.A. Reference Dose for Chronic Oral Exposure (RfD)
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Last Revised — 03/01/1991
The oral Reference Dose (RfD) is based on the assumption that thresholds
exist for certain toxic effects such as cellular necrosis. It is expressed
in units of mg/kg-day. In general, the RfD is an estimate (with uncertainty
spanning perhaps an order of magnitude) of a daily exposure to the human
population (including sensitive subgroups) that is likely to be without
an appreciable risk of deleterious effects during a lifetime. Please refer
to the Background Document for an elaboration of these concepts. RfDs
can also be derived for the noncarcinogenic health effects of substances
that are also carcinogens. Therefore, it is essential to refer to other
sources of information concerning the carcinogenicity of this substance.
If the U.S. EPA has evaluated this substance for potential human carcinogenicity,
a summary of that evaluation will be contained in Section II of this file.
__I.A.1. Oral RfD Summary
Critical Effect |
Experimental Doses* |
UF |
MF |
RfD |
---|---|---|---|---|
Increased absolute 20-Month Mouse Rohm & Haas, 1977a |
NOEL: 2 ppm LEL: 20 ppm |
l00 |
1 |
3E-3 mg/kg/day |
*Conversion Factors: 1 ppm = 0.15 mg/kg/day (assumed mouse food consumption)
__I.A.2. Principal and Supporting Studies (Oral RfD)
Rohm and Haas Company. 1977a. MRID No. 00037939. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Fifty Charles River CD-l mice/sex/dose were fed diets containing 2, 20, and 200 ppm of oxyfluorfen (87.7% active ingredient) for 20 months. The following results were noted: 1) increased absolute liver weight at 20 ppm; 2) necrosis, regeneration, and hyperplastic nodules in liver at 20 ppm; and 3) increased incidence of effects at 200 ppm.
__I.A.3. Uncertainty and Modifying Factors (Oral RfD)
UF — An uncertainty factor of 100 was used to account for the interspecies differences and the spectrum of sensitivity in the human population.
MF — None
__I.A.4. Additional Studies/Comments (Oral RfD)
Data Considered for Establishing the RfD
1) 20-Month Feeding (oncogenic) - mice: Principal study - see previous discussion; core grade minimum
2) 2-Year Feeding - dog: NOEL=100 ppm (2.5 mg/kg/day); LEL=600 ppm (15 mg/kg/day), (increased liver weight, elevated alkaline phosphatase; increased bile pigmented hepatocytes); core grade minimum (Rohm and Haas, 1981)
3) 2-Year Feeding (oncogenic) - rat: Systemic NOEL=40 ppm (2 mg/kg/day); Systemic LEL=800/600 ppm (40/30 mg/kg/day) (minimal hypertrophy of centrilobular hepatocytes of the liver); core grade minimum (Rohm and Haas, 1977b)
4) 3-Generation Reproduction - rat: NOEL=10 ppm (0.5 mg/kg/day); LEL=100 ppm (5 mg/kg/day); core grade minimum (Rohm and Haas, 1977c)
5) Teratology - rat: Fetotoxic NOEL=l00 mg/kg/day; Fetotoxic LEL=l000 mg/kg/day; Teratogenic NOEL=1000 mg/kg/day (HDT); core grade minimum (Rohm and Haas, 1977d)
6) Teratology - rabbit: Maternal NOEL=l0 mg/kg/day; Maternal LEL=30 mg/kg/day (anorexia, decreased body weight gain); Fetotoxic NOEL=l0 mg/kg/day; Fetotoxic LEL=30 mg/kg/day (fused sternebrae); Teratogenic NOEL=l000 mg/kg/day; core grade supplementary (Rohm and Haas, 1982)
Data Gap(s): Rabbit Teratology Study
__I.A.5. Confidence in the Oral RfD
Study — High
Database — High
RfD — High
The principal study appears to be of good quality and, therefore, is given a high rating. The data and supporting studies are of high quality; thus, the database is given a high confidence rating. High confidence in the RfD follows.
__I.A.6. EPA Documentation and Review of the Oral RfD
Pesticide Registration Files
Agency Work Group Review — 06/10/1986
Verification Date — 06/10/1986
Screening-Level Literature Review Findings — A screening-level review conducted by an EPA contractor of the more recent toxicology literature pertinent to the RfD for Oxyfluorfen conducted in September 2002 identified one or more significant new studies. IRIS users may request the references for those studies from the IRIS Hotline at hotline.iris@epa.gov or (202)566-1676.
__I.A.7. EPA Contacts (Oral RfD)
Please contact the IRIS Hotline for all questions concerning this assessment or IRIS, in general, at (202)566-1676 (phone), (202)566-1749 (FAX) or hotline.iris@epa.gov (internet address).
_I.B. Reference Concentration for Chronic Inhalation Exposure (RfC)
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Not available at this time.
_II. Carcinogenicity Assessment for Lifetime Exposure
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Not available at this time.
_III.
[reserved]
_IV. [reserved]
_V. [reserved]
_VI. Bibliography
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Last Revised — 03/01/1991
_VI.A. Oral RfD References
Rohm and Haas Company. 1977a. MRID No. 00037939. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Rohm and Haas Company. 1977b. MRID No. 00083445, 00135072. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Rohm and Haas Company. 1977c. MRID No. 00135073. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Rohm and Haas Company. 1977d. MRID No. 00083444. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Rohm and Haas Company. 1981. MRID No. 00071918. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
Rohm and Haas Company. 1982. MRID No. 00094502. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
_VI.B. Inhalation RfC References
None
_VI.C. Carcinogenicity Assessment References
None
_VII. Revision History
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Date |
Section |
Description |
---|---|---|
12/01/1988 | I.A.1. | Species corrected |
03/01/1991 | I.A.4. | Citations added |
03/01/1991 | VI. | Bibliography on-line |
01/01/1992 | IV. | Regulatory Action section on-line |
04/01/1997 | III., IV., V. | Drinking Water Health Advisories, EPA Regulatory Actions, and Supplementary Data were removed from IRIS on or before April 1997. IRIS users were directed to the appropriate EPA Program Offices for this information. |
12/03/2002 | I.A.6. | Screening-Level Literature Review Findings message has been added. |
_VIII. Synonyms
Substance Name — Oxyfluorfen
CASRN — 42874-03-3
Primary Synonym — Goal
Last Revised — 01/31/1987
- 42874-03-3
- 2-CHLORO-1-(3-ETHOXY-4-NITROPHENOXY)-4-TRIFLUOROMETHYLBENZENE
- 2-CHLORO-alpha,alpha,alpha-TRIFLUORO-p-TOLYL-3-ETHOXY-4-NITROPHENYL ETHER
- ETHER, 2-CHLORO-alpha,alpha,alpha-TRIFLUORO-p-TOLYL 3-ETHOXY-4-NITROPHENYL
- GOAL
- Oxyfluorfen
- RH-2915