CIT ID: 5169
Program date: Wednesday, September 13, 2006, 3:00:00 PM
Presented by: Olufunmilayo Olopade, M.D., University of Chicago

Abstract:

Epidemiological studies have provided much information on important risk factors for breast cancer. These include age, family or personal history of breast cancer, reproductive history and exposures to specific carcinogens. The importance of epigenetic regulation in breast cancer progression is increasingly recognized. While germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, play a significant role in a small fraction of breast cancer cases, we have found that an epigenetically-induced modulation of BRCA1 gene expression occurs in a significant proportion of sporadic breast cancers.

For more information, visit
http://www.uchospitals.edu/physicians/olufunmilayo-olopade.html

WALS

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	Description	Runtime			Description	Runtime
	Enhanced Audio Podcast	1:03:45			Enhanced Video Podcast	1:03:45

CIT ID: 5207
Program date: Monday, September 11, 2006, 12:00:00 PM
Presented by: Randy Blakely, Ph.D., Vanderbilt University

Abstract:

Dr. Blakely’s research explores the molecular basis for neurotransmitter transporter structure, function and regulation. He uses chimera, site-directed mutagenesis and site-specific chemical modification strategies to explore the topology and quaternary structure of biogenic amine transporters. He is currently evaluating what molecules control the proper localization and activity of transporter proteins using genetic (C.elegans), and molecular biologic methods. He is also evaluating whether human transporter polymorphisms impact the biosynthesis, trafficking and function of transporters and confer increased risk for autonomic, neurologic and mental disorders.

More information regarding this important research can be obtained from his website at
https://medschool.mc.vanderbilt.edu/blakely

NIH Neuroscience Seminar Series

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	Description	Runtime			Description	Runtime
	Enhanced Audio Podcast	1:13:58			Enhanced Video Podcast	1:13:58

CIT ID: 5104
Program date: Thursday, July 13, 2006, 12:00:00 PM
Presented by: Sir Richard Peto, FRSD, University of Oxford, United Kingdom

Abstract:

Sir Richard Peto observes that worldwide, most premature deaths are from just a few major external causes or diseases, and practicable ways exist of controlling several of these big risks. He notes that improving treatment of disease and reducing tobacco deaths have halved the number of premature deaths in Britain over the past few decades. Sir Richard Peto developed a statistical technique, “meta-analysis,” that helped improve the treatment of heart disease and breast cancer. He predicts smoking will cause one billion avoidable deaths this century if current smoking patterns persist.

For more information, visit
http://www.fic.nih.gov/news/events/peto_lecture.pdf

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	Description	Runtime			Description	Runtime
	Audio	01:23:13			Video	01:23:13

CIT ID: 4959
Program date: Wednesday, May 31, 2006, 12:00:00 PM
Presented by: Robin Bush, University of California, Irvine

Abstract:

Evolution and Medicine

Robin Bush will speak on about the use of phylogenetics to determine how pathogens evolve in response to host immune systems.

Lecture series presented by National Institute of General Medical Sciences, the Office of Science Education, and the National Human Genome Research Institute. For more information, visit
http://www.nigms.nih.gov/News/Meetings/EvolutionSeries

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	Description	Runtime			Description	Runtime
	Enhanced Audio Podcast	52:16			Enhanced Video Podcast	52:16

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