3D Structures & Tool DevelopmentThomas A. Darden, Ph.D.
Principal Investigator Tel (919) 541-4933 Fax (919) 541-0779 darden@niehs.nih.gov P.O. Box 12233 Mail Drop F0-08 Research Triangle Park, North Carolina 27709 Delivery Instructions Research SummaryThe Computational Chemistry & Molecular Modeling Group serves two major roles:
Three-dimensional structures are currently being generated at an exponential rate from experimental laboratories that focus on structure determination—X-ray, electron crystallography and NMR spectroscopy. Likewise, one-dimensional sequences of proteins and nucleic acids are appearing, also at an exponential rate. The appearance of sequences, however, is at a faster rate. The task, then, is to use the smaller data base (3D) to estimate 3D structures for molecules in the larger data base (1D). Major areas of research:
Current projects:
Thomas A. Darden, Ph.D., heads the Computational Chemistry & Molecular Modeling Group within the Laboratory of Structural Biology. He received his Ph.D. in mathematical statistics from the University of California, Berkeley in 1979. He has published over 120 peer-reviewed articles in leading biomedical journals, as well as several book chapters. He served as an instructor at University of Wisconsin, Madison before joining NIEHS in 1981. |
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