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The Center for Hepatotoxicology develops and applies a systems toxicology
approach to the analysis of questions in liver toxicity based on an integrated
cell, molecular, transcriptomic, proteomic, and metabolomic platform. Biomarker
profiles are generated for more effective assessment of risk for acute toxicity
and liver cancer development. Biomarkers of liver injury and disease in mouse,
rat, and human samples are developed through an integrated omics analysis of
biofluids and tissues from liver injury and disease. The integration of
signaling pathway for cell proliferation, apoptosis, and differentiation
provides the framework to assess these biomarkers. Development of new methods
for identification and limiting the effect of agents to cause liver toxicity is
of great importance in support of the FDA's Critical Path Initiative and the
long-term impact on public health.
Contact Information
For more information please contact Dr. James Fuscoe, at 870-543-7126 or
james.fuscoe@fda.hhs.gov
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2008-MAY-23.