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VISTA is a comprehensive suite of programs and databases for comparative analysis of genomic sequences. There are two ways of using VISTA - you can submit your own sequences and alignments for analysis (VISTA servers) or examine pre-computed whole-genome alignments of different species.

VISTA Servers

mVISTA

Align and compare your sequences from multiple species

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rVISTA

Regulatory VISTA combines transcription factor binding sites database search with a comparative sequence analysis. It can be used directly or through mVISTA, Genome VISTA, or VISTA Browser

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GenomeVISTA

Compare your sequences with whole genome assemblies. It will automatically find the ortholog, obtain the alignment and VISTA plot. View your alignment together with pre-computed alignments of other species in the same interval.

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Phylo-VISTA

Analyze multiple DNA sequence alignments of sequences from different species while considering their phylogenic relationships.

wgVISTA

Align sequences up to 10Mb long (finished or draft) including microbial whole-genome assemblies.

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Precomputed Whole Genome Alignments

VISTA Browser

Allows the user to examine pre-computed alignments of whole genome assemblies. Pairwise and multiple alignments are available.

Whole Genome rVISTA

Whole Genome rVISTA evaluates which conserved between pairs of species transcription factor binding sites (TFBS) are over-represented in upstream regions in a group of genes.

Microbial genomes

Pre-computed full scaffold alignments for microbial genomes are available as the VISTA component of IMG (Integrated Microbial Genomes) developed in DOE Joint Genome Institute.

Other Projects

PGA

Berkeley PGA uses a comparative genomic approach first to identify, and then to determine the function of elements regulating the expression of genes affecting the cardiovascular system.

SNP-VISTA

Visualization of mutations in genes and discovery of recombination points in microbial populations.

TreeQ-Vista

Interactive tree visualization tool with functional annotation query capabilities.

VISTA tutorial and training materials from OpenHelix

June 2008

Added whole-genome multiple alignment of seven vertebrates: Human -- Rhesus -- Horse -- Dog -- Mouse -- Rat -- Chicken

April 2008

Added whole-genome multiple alignments of:

January 2008

43 Alignments of 28 genomes sequenced by JGI are added to VISTA Browser. Among these species are fungi, algae, plants, and others.

December 2007

Added whole-genome multiple alignment of four primates Human -- Orangutan -- Rhesus -- Marmoset

October 2007

The mVISTA and GenomeVISTA servers can now automatically retrieve gene annotations for GenBank sequences.

Added whole genome alignment of:

September 2007

Added whole genome alignments of:

The wgVISTA server can now automatically retrieve gene annotations for GenBank sequences.

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