Drug

Species

Indication

Dosage regimen

Limitations/Comments

Immersion

Formalin (Parasite-S® by Western Chemical and

Formalin-F ™ by Natchez Animal Supply Co.)

All finfish

Control external protozoa (Chilodonella, Costia, Epistylis, Ichthyophthirius, Scyphidia, Trichodina spp.) and monogenetic trematodes (Cleidodiscus, Dactylogyrus, Gyrodactylus spp.)

Tanks and raceways: Salmon & trout
Above 50 °F: up to 170 µl/L for up to 1 hr
Below 50 °F: up to 250 µl/L for up to 1 hr
All other finfish up to 250 µl/L for up to 1 hr

Earthen ponds: 15 to 25 µl/L indefinitely

--Drug must not be subjected to temperature below 40 °F
--Do not apply to ponds when water is warmer than 80 °F, there is a heavy phytoplankton bloom, or dissolved oxygen is less than 5 mg/L
--Ponds may be retreated in 5 to 10 days if needed
--Do not treat ponds containing striped bass                                    --Test on a small number from each lot to check for any unusual sensitivity to formalin before proceeding     

All finfish eggs

Control fungi of the family Saprolegniaceae

All finfish eggs:
1000-2000 ppm for 15 min.; Acipenseriformes up to 1500 ppm for 15 min.

Preliminary bioassay should be conducted to determine species sensitivity

Penaeid shrimp

Control protozoan parasites (Bodo, Epistylis and Zoothamnium spp.)

Tanks and raceways:
50 to 100 µl/L for up to and 4 hours daily;

Earthen ponds:
25 µl/L as single treatment

--Drug must not be subjected to temperature below 40 °F
--Do not apply to ponds when water is warmer than 80 °F,
when there is a heavy phytoplankton bloom, or when dissolved oxygen is less than 5 mg/L

--Ponds may be retreated in 5 to 10 days if needed

Formalin (Paracide-F® by Argent Laboratories)

Salmon, trout, catfish, largemouth bass, and bluegill

Control external protozoa (Chilodonella, Costia, Epistylis, Ichthyophthirius, Scyphidia, Trichodina spp.) and monogenetic trematodes (Cleidodiscus, Dactylogyrus, Gyrodactylus spp.)

Tanks and raceways: Salmon & trout
Above 50 °F: up to 170 µl/L for up to 1 hr
Below 50 °F: up to 250 µl/L for up to 1 hr
Catfish, largemouth bass and bluegill: up to 250 µl/L for up to 1 hr

Earthen ponds: 15 to 25 µl/L indefinitely

--Drug must not be subjected to temperature below 40 ° F
--Do not apply to ponds when water is warmer than 80 ° F, when there is a heavy phytoplankton bloom, or when dissolved oxygen is less than 5 mg/L
--Ponds may be retreated in 5 to 10 days if needed
--Do not treat ponds containing striped bass

Salmon, trout, and esocid eggs

Control fungi of the family Saprolegniaceae

1000-2000 ppm for 15 min.

Preliminary bioassay should be conducted to determine species sensitivity

Hydrogen Peroxide (35% PEROX-AID® by Eka Chemicals Inc.)

Freshwater-reared finfish eggs

Control mortality due to saprolegniasis

Coldwater and coolwater: 500 to 1000 mg/L for 15 minutes in a continuous flow system once per day on consecutive or alternate days until hatch

Warmwater: 750 to 1000 mg/L for 15 minutes in a continuous flow system once per day on consecutive or alternate days until hatch

--Initial bioassay on a small number is recommended before treating the entire group

Freshwater-reared salmonids

Control mortality due to bacterial gill disease (Flavobacterium branchiophilum)

100 mg/L (30 minutes) or 50 to 100 mg/L (60 minutes) once per day on alternate days for three treatments

--Initial bioassay on a small number is recommended before treating the entire group

Freshwater-reared coolwater finfish and channel catfish

Control mortality due to external columnaris disease (Flavobacterium columnare/ Flexibacter columnaris)

Fingerling and adults (except northern pike and paddlefish):  50 to 75 mg/L (60 minutes) once per day on alternate days for three treatments

Fry (except northern pike, pallid sturgeon, and paddlefish): 50 mg/L (60 minutes) once per day on alternate days  for three treatments

--Use with caution on walleye

--Initial bioassay on a small number is recommended before treating the entire group

Oxytetracycline hydrochloride (OxyMarine by Alpharma Inc.;

Oxytetracycline HCl Soluble Powder-343 by Phoenix Scientific, Inc.; and

TERRAMYCIN-343 (oxytetracycline HCl) Soluble Powder by Pfizer, Inc.)

Finfish fry and fingerlings

Mark skeletal tissues

200 to 700 mg oxytetracycline hydrochloride (buffered) per liter of water for 2 to 6 hours

Tricaine methanesulfonate (Finquel® by Argent Laboratories and

Tricaine-S by Western Chemical, Inc.)

Fish (Ictaluridae, Salmonidae, Esocidae, Percidae), aquatic amphibians, and other aquatic poikilotherms

Temporary immobilization

15 to 330 mg/L (fish)

1:1,000 to 1:20,000
(other poikilotherms)

--Powder is added to water
--Concentration depends upon desired degree of anesthesia, species, size, water temperature and softness, stage of development; preliminary tests of solution should be made with a few fish
--21 day withdrawal time (fish); laboratory or hatchery use only in other poikilotherms --Water temperature over 50° F (10° C)

Drug

Species

Indication

Dosage regimen

Limitations/Comments

Injectable

Chorionic Gonadotropin, (Chorulon® by Intervet Inc.)

Male and female brood finfish

Aid in improving spawning function

50 to 510 IU/lb males
67 to 1816 IU/lb females

--Intramuscular injection          --Up to three doses. Total dose not to exceed 25,000 IU in fish intended for human consumption                             --Prescription product restricted to use by or on the order of a licensed veterinarian

Medicated Article/Feed

Florfenicol (Aquaflor® by Schering-Plough Animal Health Corporation)

Catfish

Control of mortality due to enteric septicemia of catfish associated with Edwardsiella ictaluri

10 mg/kg/day for 10 consecutive days

--Veterinary Feed Directive (VFD) drug
--12 day withdrawal time

Oxytetracycline dihydrate (Terramycin® 200 for Fish by Phibro Animal Health)

Pacific salmon

Mark skeletal tissue

250 mg/kg/day for 4 days

--Salmon < 30 g
--In feed as sole ration
--7 day withdrawal time

Salmonids

Control ulcer disease,
furunculosis, bacterial hemorrhagic septicemia, and pseudomonas disease (Hemophilus piscium, Aeromonas salmonicida,

A. liquefaciens, Pseudomonas)

2.5 to 3.75 g/100 lb/day for 10 days

--In mixed ration
--Water temperature not below 48.2° F
--21 day withdrawal time

Catfish

Control bacterial hemorrhagic septicemia and pseudomonas disease

(A. liquefaciens, Pseudomonas)

2.5 to 3.75 g/100 lb/day for 10 days

--In mixed ration
--Water temperature not below 62° F
--21 day withdrawal time

Lobster

Control gaffkemia
(Aerococcus viridans)

1 g/lb medicated feed for 5 days

--In feed as sole ration
--30 day withdrawal time

Sulfadimethoxine, ormetoprim (Romet®-30 by Pharmaq AS)

Salmonids

Control furunculosis
(Aeromonas salmonicida)

50 mg/kg/days for 5 days

--In feed
--42 day withdrawal time

Catfish

Control enteric septicemia (Edwardsiella ictaluri)

50 mg/kg/days for 5 days

--In feed
--3 day withdrawal time

Sulfamerazine (by Alpharma, Inc.)

Rainbow, brook, and brown trout

Control furunculosis

--10 g/100 lb/day for up to 14 days

--In feed
--21 day withdrawal time
--Not currently available