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Solicitation of Information on the Use of Phenethylamine-Related Compounds
FR Doc E6-17523 [Federal Register: October 20, 2006 (Volume 71, Number 203)]
[Notices] [Page 62017-62018] From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr20oc06-90]
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DEPARTMENT OF JUSTICE
Drug Enforcement Administration
[Docket No. DEA-274N]
Solicitation of Information on the Use of Phenethylamine-Related Compounds
AGENCY: Drug Enforcement Administration (DEA), Department of Justice.
ACTION: Notice, solicitation of information.
SUMMARY: The DEA is soliciting information on substances that are
related in chemical structure to phenethylamine (see supplementary information).
The Controlled Substances Act (CSA), Title 21 of the United States Code (U.S.C.)
Sec. 812(c) schedule I (Title 21 of the Code of Federal Regulations (CFR) Sec.
1308.11(d)), lists certain phenethylamines as schedule I controlled substances.
Some phenethylamines that are not controlled under the CSA produce central
nervous system effects that are similar to phenethylamines that are controlled
under the CSA. DEA is requesting information to help determine the impact on
business if these substances were to be placed under control in the CSA.
DATES: Written comments must be postmarked, and electronic comments
must be sent, on or before December 19, 2006.
ADDRESSES: To ensure proper handling of comments, please reference "Docket
No. DEA-274N" on all written and electronic correspondence. Written comments
being sent via regular mail should be sent to the Deputy Assistant
Administrator, Office of Diversion Control, Drug Enforcement Administration,
Washington, DC 20537, Attention: DEA Federal Register Representative/ODL.
Written comments sent via express mail should be sent to DEA Headquarters,
Attention: DEA Federal Register Representative/ODL, 2401 Jefferson-Davis
Highway, Alexandria, VA 22301. Comments may be directly sent to DEA
electronically by sending an electronic message to dea.diversion.policy@usdoj.gov.
DEA will accept attachments to electronic comments in Microsoft Word,
WordPerfect, Adobe PDF, or Excel file formats only. DEA will not accept any file
format other than those specifically listed here.
FOR FURTHER INFORMATION CONTACT: Christine A. Sannerud, Ph.D., Chief,
Drug and Chemical Evaluation Section, Office of Diversion Control, Drug
Enforcement Administration, Washington, DC 20537; Telephone: (202) 307- 7183.
SUPPLEMENTARY INFORMATION: Phenethylamine is a compound in which the
chemical structure is a benzene ring substituted with a 2-aminoethyl chain.
Although phenethylamine itself is not a controlled substance, its chemical
structure constitutes the skeletal makeup of phenethylamines listed in schedule
I of the CSA, which are classified as hallucinogenic substances. Phenethylamines
are also found in schedule II and IV of the CSA.
Phenethylamine is sometimes substituted on the benzene ring or the
2-aminoethyl chain or both with various substituents. Title 21 CFR 1308.11(d)
lists specific substituted phenethylamines in schedule I. Also included in
schedule I are the salts, isomers, and salts of isomers of the listed
phenethylamines. The term isomer, as used in this section, means the optical,
geometric, and positional isomers.
Individuals have published detailed methods of synthesis for substituted
phenethylamines and have reported pharmacological effects based on user
experiences. Law enforcement personnel encounter such phenethylamines, but
because they are substituted differently than those listed or described in the
CSA, they are not subject to direct control in schedule I. However, some of
these substances can be treated as schedule I controlled substance analogues if
intended for human consumption (21 U.S.C. 802(32); 813).
DEA is soliciting information on (1) the commercial uses for phenethylamines,
(2) activities involving research and development, (3) phenethylamines as
intermediates or analytical standards, (4) import and domestic sources for
phenethylamines, and (5) any planned or anticipated uses for phenethylamines.
DEA invites interested persons to provide any information on the uses of
phenethylamines in industry, academia, research and development, or other
applications. Both quantitative and qualitative information are sought.
Although information is requested for all phenethylamine substances
regardless of substitutions, DEA is particularly interested in phenethylamines
that meet one or more of the following conditions: any compound structurally
derived from phenethylamine, or from any N- alkylphenethylamine, any alpha-alkylphenethylamine,
or any N-alkyl- alpha-alkylphenethylamine, by substitution on the ring to any
extent with alkyl, cycloalkyl, cycloalkenyl, alkoxy, alkylthio, alkylhalide,
alkylene-dioxy, acyloxy, or halide substituents, whether or not further
substituted on the ring by one or more other univalent substituents. DEA is
especially interested in learning of the uses of the following phenethylamines:
1,4-Dimethoxynaphthyl-2-ethylamine 1,4-Dimethoxynaphthyl-2-isopropylamine
2-(2,5-Dimethoxy-4-methylphenyl)-cyclopropylamine
2,3,4,5-Tetramethoxyamphetamine 2,3,4-Trimethoxyamphetamine
2,3,4-Trimethoxyphenethylamine 2,3,5-Trimethoxyamphetamine
2,3,6-Trimethoxyamphetamine 2,3-Dimethoxy-4,5-methylenedioxyamphetamine
2,4,5-Triethoxyamphetamine 2,4,5-Trimethoxyamphetamine
2,4,5-Trimethoxyphenethylamine 2,4,6-Trimethoxyamphetamine
2,4-Diethoxy-5-methoxyamphetamine 2,4-Dimethoxy-5-ethoxyamphetamine
2,4-Dimethoxyamphetamine 2,5,beta-Trimethoxy-4-methylphenethylamine
2,5-Bismethylthio-4-methylamphetamine 2,5-Diethoxy-4-methoxyamphetamine
2,5-Dimethoxy-3,4-methylenedioxyamphetamine
2,5-Dimethoxy-4,N-dimethylamphetamine 2,5-Dimethoxy-4-ethoxyamphetamine
2,5-Dimethoxy-4-propoxyamphetamine
2,5-Dimethoxy-alpha-ethyl-4-methylphenethylamine
2,5-Dimethoxy-beta-hydroxy-4-methylphenethylamine
2,5-Dimethoxy-N,N-dimethyl-4-iodoamphetamine 2,5-Dimethoxy-N-hydroxy-4-(n)-propylthiophenethylamine
2,5-Dimethoxy-N-hydroxy-4-(sec)-butylthiophenethylamine
2,5-Dimethoxy-N-hydroxy-4-ethylthiophenethylamine 2,5-Dimethoxyphenethylamine
2,N-Dimethyl-4,5-methylenedioxyamphetamine 2-Bromo-4,5-methylenedioxyamphetamine
2-Ethoxy-4,5-dimethoxyamphetamine 2-Methoxy-3,4-methylenedioxyamphetamine
2-Methoxy-4,5-diethoxyamphetamine 2-Methoxy-4,5-methylenedioxyamphetamine
2-Methoxy-4-methyl-5-methylsulfinylamphetamine
2-Methoxy-4-methyl-5-methylthioamphetamine
2-Methylthio-3,4-dimethoxyphenethylamine
2-Methylthio-3,4-methylenedioxyamphetamine 2-Methylthio-4,5-dimethoxyamphetamine
3,4,5,beta-Tetramethoxyphenethylamine 3,4,5-Triethoxyphenethylamine
3,4,5-Trimethoxyphenethylamine 3,4-Diethoxy-5-methoxyphenethylamine
3,4-Diethoxy-5-methylthiophenethylamine 3,4-Dimethoxy-5-ethoxyphenethylamine
3,4-Dimethoxy-5-propoxyphenethylamine 3,4-Dimethoxyamphetamine
3,4-Dimethoxy-beta-hydroxyphenethylamine 3,4-Dimethoxyphenethylamine
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3,4-Dimethyl-2,5-dimethoxyamphetamine
3,4-Dimethyl-2,5-dimethoxyphenethylamine 3,4-Ethylenedioxy-5-methoxyamphetamine
3,4-Methylenedioxyphenethylamine 3,4-Norbornyl-2,5-dimethoxyamphetamine
3,4-Norbornyl-2,5-dimethoxyphenethylamine
3,4-Tetramethylene-2,5-dimethoxyamphetamine
3,4-Tetramethylene-2,5-dimethoxyphenethylamine
3,4-Trimethylene-2,5-dimethoxyamphetamine
3,4-Trimethylene-2,5-dimethoxyphenethylamine
3,5-Diethoxy-4-ethylthiophenethylamine 3,5-Diethoxy-4-methoxyphenethylamine
3,5-Diethoxy-4-methylthiophenethylamine 3,5-Dimethoxy-4-ethylthiophenethylamine
3,5-Dimethoxy-4-isopropoxyphenethylamine
3,5-Dimethoxy-4-methallyloxyphenethylamine
3,5-Dimethoxy-4-phenethyloxyphenethylamine 3,5-Dimethoxy-4-propoxyphenethylamine
3-Ethoxy-4-ethylthio-5-methoxyphenethylamine
3-Ethoxy-4-methoxy-5-methylthiophenethylamine
3-Ethoxy-5-ethylthio-4-methoxyphenethylamine
3-Ethoxy-5-methoxy-4-methylthiophenethylamine
3-Methoxy-4,5-methylenedioxyphenethylamine 3-Methoxy-4-ethoxyphenethylamine
3-Methylthio-2,4-dimethoxyphenethylamine
3-Methylthio-4,5-dimethoxyphenethylamine
4-(2-Fluoroethyl)-2,5-dimethoxyamphetamine
4-(2-Fluoroethylthio)-2,5-dimethoxyphenethylamine
4-(2-Methoxyethylthio)-2,5-dimethoxyphenethylamine
4-(sec)-Butylthio-2,5-dimethoxyphenethylamine
4-(tert)-Butylthio-2,5-dimethoxyphenethylamine
4,5-Diethoxy-3-ethylthiophenethylamine 4,5-Dimethoxy-3-ethylthiophenethylamine
4,5-Thiomethyleneoxy-2-methoxyamphetamine 4-Allyloxy-3,5-dimethoxyphenethylamine
4-Amyl-2,5-dimethoxyamphetamine 4-Benzyloxy-3,5-dimethoxyamphetamine
4-Bromo-2,5,beta-trimethoxyphenethylamine
4-Bromo-2,5-dimethoxy-N-methylamphetamine 4-Bromo-3,5-dimethoxyamphetamine
4-Butoxy-3,5-dimethoxyphenethylamine 4-Butyl-2,5-dimethoxyamphetamine
4-Chloro-2,5-dimethoxyamphetamine 4-Chloro-2,5-dimethoxyphenethylamine
4-Cyclopropylmethoxy-3,5-dimethoxyphenethylamine
4-Cyclopropylmethylthio-2,5-dimethoxyphenethylamine
4-Cyclopropylthio-2,5-dimethoxyphenethylamine 4-Ethoxy-3,5-dimethoxyamphetamine
4-Ethoxy-3,5-dimethoxyphenethylamine
4-Ethoxy-3-ethylthio-5-methoxyphenethylamine
4-Ethoxy-5-methoxy-3-methylthiophenethylamine
4-Ethyl-2,5-dimethoxyphenethylamine 4-Ethyl-2-methoxy-5-methylthioamphetamine
4-Ethyl-5-methoxy-2-methylthioamphetamine 4-Ethylthio-2,5-dimethoxyamphetamine
4-Ethylthio-2,5-dimethoxyphenethylamine 4-Fluoro-2,5-dimethoxyphenethylamine
4-Iodo-2,5-dimethoxyamphetamine 4-Iodo-2,5-dimethoxyphenethylamine
4-Isopropoxy-2,5-dimethoxyphenethylamine
4-Isopropylthio-2,5-dimethoxyamphetamine
4-Isopropylthio-2,5-dimethoxyphenethylamine
4-Isopropylthio-2,6-dimethoxyphenethylamine
4-Methoxy-2,3-methylenedioxyamphetamine 4-Methyl-2,5-dimethoxyphenethylamine
4-Methyl-2,6-dimethoxyamphetamine 4-Methyl-3,5-Dimethoxyphenethylamine
4-Methylseleno-2,5-dimethoxyphenethylamine
4-Methylthio-2,3-dimethoxyphenethylamine 4-Methylthio-2,5-dimethoxyamphetamine
4-Methylthio-2,5-dimethoxyphenethylamine
4-Methylthio-3,5-dimethoxyphenethylamine 4-Nitro-2,5-dimethoxyamphetamine
4-Nitro-2,5-dimethoxyphenethylamine 4-Phenylthio-2,5-dimethoxyamphetamine
4-Propyl-2,5-dimethoxyamphetamine 4-Propyl-2,5-dimethoxyphenethylamine
4-Propylthio-2,5-dimethoxyamphetamine 4-Propylthio-3,5-dimethoxyphenethylamine
4-Propynyloxy-3,5-dimethoxyphenethylamine
4-Thiobutoxy-3,5-dimethoxyphenethylamine
4-Trideuteromethyl-3,5-dimethoxyphenethylamine 5-Bromo-2,4-dimethoxyamphetamine
5-Ethoxy-2-methoxy-4-methylamphetamine
5-Methoxy-4-methyl-2-methylthioamphetamine 5-Methylthio-2,4-dimethoxyamphetamine
alpha,alpha,N-Trimethyl-3,4-methylenedioxyphenethylamine
alpha,alpha-Dimethyl-3,4-methylenedioxyphenethylamine
alpha-Ethyl-3,4,5-trimethoxyphenethylamine
alpha-Ethyl-3,4-methylenedioxyphenethylamine
Benzofuran-2,2-dimethyl-5-methoxy-6-(2-aminopropane)
Benzofuran-2-methyl-5-methoxy-6-(2-aminopropane)
beta,beta-Dideutero-3,4,5-trimethoxyphenethylamine
beta-Methoxy-3,4-methylenedioxyphenethylamine
N-(2-Hydroxyethyl)-3,4-methylenedioxyamphetamine
N-(2-Methoxyethyl)-3,4-methylenedioxyamphetamine
N,alpha-diethyl-3,4-methylenedioxyphenethylamine
N,N-Dimethyl-3,4-methylenedioxyamphetamine N-Allyl-3,4-methylenedioxyamphetamine
N-Benzyl-3,4-methylenedioxyamphetamine N-Butyl-3,4-methylenedioxyamphetamine
N-Cyclopropylmethyl-3,4-methylenedioxyamphetamine
N-Ethyl-alpha-propyl-3,4-methylenedioxyphenethylamine
N-Hydroxy-N-methyl-3,4-methylenedioxyamphetamine
N-Isopropyl-3,4-methylenedioxyamphetamine
N-Methoxy-3,4-methylenedioxyamphetamine N-Methyl-2,5-dimethoxyamphetamine
N-Methyl-2-methoxy-4,5-methylenedioxyamphetamine
N-Methyl-3,4-ethylenedioxyamphetamine N-Methyl-4-methoxyamphetamine
N-Methyl-alpha-ethyl-3,4-methylenedioxyphenethylamine
N-Methyl-alpha-propyl-3,4-methylenedioxyphenethylamine
N-Propargyl-3,4-methylenedioxyamphetamine N-Propyl-3,4-methylenedioxyamphetamine
Such information may be submitted to the Drug Enforcement Administration
using the information in the ADDRESSES section above. Such information is
requested on or before December 19, 2006. Information designated as confidential
or proprietary will be treated accordingly. Confidential business information is
protected from disclosure under Exemption 4 of the Freedom of Information Act, 5
U.S.C. 552(b)(4)(FOIA) and the Department of Justice procedures set forth in 28
CFR 16.8.
Dated: October 11, 2006.
Joseph T. Rannazzisi, Deputy Assistant Administrator, Office of Diversion
Control.
[FR Doc. E6-17523 Filed 10-19-06; 8:45 am]
BILLING CODE 4410-09-P
NOTICE: This is an
unofficial version. An official version of these publications may be obtained
directly from the Government Printing Office (GPO).
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