Volume 3, Number 1 - December 2005

The Neurobiology of Cocaine Addiction
[PDF - 308K]
Eric J. Nestler, M.D., Ph.D.

Hyman, S.E., and Malenka, R.C., 2001. Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews. Neuroscience 2(10):695-703. Abstract Available

Kalivas, P.W., and McFarland, K., 2003. Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berlin) 168(1-2):44-56. Abstract Available

Koob, G.F.; Sanna, P.P.; and Bloom, F.E., 1998. Neuroscience of addiction. Neuron 21(3):467-476. Abstract Available

McClung, C.A., and Nestler, E.J., 2003. Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nature Neuroscience 6(11):1208-1215. Abstract Available

McClung, C.A. et al., 2004. ΔFosB: A molecular switch for long-term adaptation in the brain. Molecular Brain Research 132(2):146-154. Abstract Available

Nestler, E.J., 2001. Molecular basis of neural plasticity underlying addiction. Nature Reviews. Neuroscience 2(2):119-128. Abstract Available

Nestler, E.J.; Barrot, M.; and Self, D.W., 2001. ΔFosB: A sustained molecular switch for addiction. Proceedings of the National Academy of Sciences of the USA 98(20):11042-11046. Abstract Available

O'Brien, C.P., 2003. Research advances in the understanding and treatment of addiction. American Journal on Addictions 12(Suppl 2):S36-S47. Abstract Available

Robinson, T.E., and Berridge, K.C., 2001. Incentive-sensitization and addiction. Addiction 96(1):103-114. Abstract Available

Volkow, N.D.; Fowler, J.S.; and Wang, G.J., 2003. The addicted human brain: Insights from imaging studies. Journal of Clinical Investigation 111(10):1444-1451. Full Text Available

Mood Disorders and Substance Use Disorder: A Complex Comorbidity
[PDF - 452K]
Susan B. Quello, B.A., B.S., Kathleen T. Brady, M.D., Ph.D., and Susan C. Sonne, Pharm.D., B.C.P.P.

Albanese, M.J.; Clodfelter, R.C. Jr.; and Khantzian, E.J., 2000. Divalproex sodium in substance abusers with mood disorder. Journal of Clinical Psychiatry 61(12):916-921. Abstract Available

Brady, K.T., et al., 1995. Valproate in the treatment of acute bipolar affective episodes complicated by substance abuse: A pilot study. Journal of Clinical Psychiatry 56(3):118-121. Abstract Available

Brown, E.S., et al., 2003. Lamotrigine in patients with bipolar disorder and cocaine dependence. Journal of Clinical Psychiatry 64(2):197-201. Abstract Available

Brown, R.A., et al., 1997. Cognitive-behavioral treatment for depression in alcoholism. Journal of Consulting & Clinical Psychology 65(5):715-726. Abstract Available

Carpenter, K.M., et al., 2004. The effect of sertraline and environmental context on treating depression and illicit substance use among methadone maintained opiate dependent patients: A controlled clinical trial. Drug and Alcohol Dependence 74:123-134. Abstract Available

Comfort, M., et al., 1999. Assessing the needs of substance abusing women. Psychometric data on the psychosocial history. Journal of Substance Abuse Treatment 17:79-83. Abstract Available

Cornelius, J.R., et al., 1997. Fluoxetine in depressed alcoholics: A double-blind, placebo-controlled trial. Archives of General Psychiatry 54(8):700-705. Abstract Available

Geller, B., et al., 1998. Double-blind and placebo-controlled study of lithium for adolescent bipolar disorders with secondary substance dependency. Journal of the American Academy of Child and Adolescent Psychiatry 37(2):171-178. Abstract Available

Hasin, D., et al., 2002. Effects of major depression on remission and relapse of substance dependence. Archives of General Psychiatry 59(4):375-380. Abstract Available

Hertzman, M., 2000. Divalproex sodium to treat concomitant substance abuse and mood disorders. Journal of Substance Abuse Treatment 18(4):371-372. Abstract Available

Hirschfeld, R.M., et al., 2003. Validity of the mood disorder questionnaire: A general population study. American Journal of Psychiatry 160(1):178-180. Full Text Available

Keller, M.B., et al., 1986. The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: A prospective follow-up. American Journal of Psychiatry 143(1):24-28. Abstract Available

Kessler, R.C., et al., 1994. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Archives of General Psychiatry 51(1):8-19. Abstract Available

Kessler, R.C., et al., 1997. Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry 54(4):313-321. Abstract Available

Markou, A.; Kosten, T.R.; and Koob, G.F., 1998. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis. Neuropsychopharmacology 19(3):135-174. Full Text Available

Nuñes, E.V., and Levin, F.R., 2004. Treatment of depression in patients with alcohol or other drug dependence. A meta-analysis. Journal of the American Medical Association 291(15):1887-1896. Abstract Available

Project MATCH Research Group, 1997. Matching alcohol treatments to client heterogeneity: Project MATCH posttreatment drinking outcomes. Journal of Studies on Alcohol 58(1):7-29. Abstract Available

Regier, D.A., et al., 1990. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. Journal of the American Medical Association 264(19):2511-2518. Abstract Available

Rounsaville, B.J., et al., 1991. Psychiatric diagnoses of treatment seeking cocaine abusers. Archives of General Psychiatry 48(1):43-51. Abstract Available

Sonne, S.C., and Brady, K.T., 1999. Substance abuse and bipolar comorbidity. Psychiatric Clinics of North America 22(3):609-627. Abstract Available

Sonne, S.C.; Brady, K.T.; and Morton W.A., 1994. Substance abuse and bipolar affective disorder. Journal of Nervous and Mental Disease 182(6):349-352. Abstract Available

Swann, A.C., et al., 1999. Differential effect of number of previous episodes of affective disorder on response to lithium or divalproex in acute mania. American Journal of Psychiatry 156(8):1264-1266. Full Text Available

Swann, A.C., et al., 2002. Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania. Neuropsychopharmacology 26(4):530-536. Abstract Available

Weiss, R.D., et al., 1998. Medication compliance among patients with bipolar disorder and substance use disorder. Journal of Clinical Psychiatry 59(4):172-174. Abstract Available

Weiss, R.D., et al., 2000. Group therapy for patients with bipolar disorder and substance dependence: Results of a pilot study. Journal of Clinical Psychiatry 61(5):361-367. Abstract Available

Young, M.A., et al., 1994. Interactions of risk factors in predicting suicide. American Journal of Psychiatry 151(3):434-435. Abstract Available

RESPONSE: THE PATH TO DOUBLE RECOVERY
[PDF - 92K]

Chang, L., et al., 2002. Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. Psychiatry Research Neuroimaging 114(2):65-79. Abstract Available

Volkow, N.D., et al., 2001. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. Journal of Neuroscience 21(23):9414-9418. Full Text Available

Methadone Treatment at Forty
[PDF - 600K]
Ira J. Marion, M.A.

Barnett, P.G., and Hui, S.S., 2000. The cost-effectiveness of methadone maintenance. Mount Sinai Journal of Medicine 67(5-6):365-374. Full Text Available

Bickel, W.K., et al., 1988. Combined behavioral and pharmacological treatment of alcoholic methadone patients. Journal of Substance Abuse 1(2):161-171. Abstract Available

D'Aunno, T.; Folz-Murphy, N.; and Lin, X., 1999. Changes in methadone treatment practices: Results from a panel study, 1988-1995. American Journal of Drug and Alcohol Abuse 25(4):681-699. Abstract Available

Hoffman, J.A., and Moolchan, E.T., 1994. The phases-of-treatment model for methadone maintenance: Implementation and evaluation. Journal of Psychoactive Drugs. 26(2):181-197. Abstract Available

Joseph, H.; Stancliff, S.; Langrod, J., 2000. Methadone maintenance treatment (MMT): A review of historical and clinical issues. Mount Sinai Journal of Medicine 67(5-6):347-364. Full Text Available

Metzger, D.S., et al., 1993. Human immunodeficiency virus seroconversion among intravenous drug users in and out of treatment: An 18 month prospective follow-up. Journal of Acquired Immune Deficiency Syndromes 6(9):1049-1056. Abstract Available

RESPONSE: STILL ROOM TO IMPROVE AN EFFECTIVE TREATMENT
[PDF - 80K]

Lofwall, M.R., et al., 2005. Characteristics of older opioid maintenance patients. Journal of Substance Abuse Treatment 28(3):265-272. Abstract Available

McLellan, A.T., et al., 1993. The effects of psychosocial services in substance abuse treatment. Journal of the American Medical Association 269(15):1953-1959. Abstract Available

Research-Practice Partners Assess Their First Joint Project
[PDF - 112K]
Suzanne L. Wenzel, Patricia Ebener, Sarah B. Hunter, Katherine E. Watkins, and James M. Gilmore; with contributions from Yolanda M. Farley, Sara E. Huish, Consuela Jackson, James P. Morrow, Roselva Romero, and Shirley A. Summers

Hunter, S., et al., 2005. Training substance abuse treatment staff to care for co-occurring disorders. Journal of Substance Abuse Treatment 28(3):239-245. Abstract Available

Watkins, K.E., et al., 2004. Prevalence and characteristics of clients with co-occurring disorders in outpatient substance abuse treatment. American Journal of Drug and Alcohol Abuse 30(4):749-764. Abstract Available