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St. Louis Encephalitis

St. Louis encephalitis is a serious viral disease that is spread by infected mosquitoes. It is one of several mosquito-borne virus diseases that can affect the central nervous system and cause severe complications and death. St. Louis encephalitis is found throughout the United States. There is no specific treatment for St. Louis encephalitis. Prevention centers on controlling mosquitoes and avoiding mosquito bites.

What is St. Louis encephalitis?

St. Louis encephalitis is a major mosquito-borne disease in the United States. It is one of a group of mosquito-borne virus diseases that can affect the central nervous system and cause severe complications and even death. Other similar diseases are eastern equine encephalitis, western equine encephalitis, and LaCrosse encephalitis.

What is the infectious agent that causes St. Louis encephalitis?

St. Louis encephalitis is caused by the St. Louis encephalitis virus, an arbovirus. Arbovirus is short for arthropod-borne virus. Arboviruses are a large group of viruses that are spread by certain invertebrate animals (arthropods), mainly blood-sucking insects. In the United States, arboviruses are usually spread by infected mosquitoes. Birds are often the source of infection for mosquitoes, which can sometimes transmit the infection to animals and, in rare cases, people.

Where is St. Louis encephalitis found?

St. Louis encephalitis is found throughout North, Central, and South America, and the Caribbean, but is a major public health problem mainly in the United States. The virus is found throughout the country, but periodic outbreaks and epidemics have occurred in the Mississippi Valley and Gulf Coast, the western states, and Florida.

How do people get St. Louis encephalitis?

The St. Louis encephalitis virus has a complex life cycle involving common birds (sparrows, finches, blue jays, robins, doves) and specific types of Culex mosquitoes that feed mainly on birds. Humans and other mammals are not an important part of the life cycle of the virus. Sometimes, however, people who live in or visit an area where the virus lives can be infected by the bite of an infected mosquito. After infection, the virus invades the central nervous system, including the spinal cord and brain.

What are the signs and symptoms of St. Louis encephalitis?

Symptoms are usually mild and include fever, headache, tiredness, and dizziness. In its more severe form, the disease can cause convulsions and death.

How is St. Louis encephalitis diagnosed?

Diagnosis is based on tests of blood or spinal fluid.

Who is at risk for St. Louis encephalitis?

Anyone can get St. Louis encephalitis, but some people are at increased risk of severe disease:

  • Elderly persons
  • Persons living in crowded, low-income areas
  • Persons who work outside or participate in outdoor recreational activities in areas where the disease is common

What is the treatment for St. Louis encephalitis?

There is no specific treatment for St. Louis encephalitis. Antibiotics are not effective against viruses, and no effective anti-viral drugs have been discovered. Care of patients centers on treatment of symptoms and complications.

How common is St. Louis encephalitis?

St. Louis encephalitis is the most common human disease caused by mosquitoes in the United States. Since 1964, there have been about 4,440 confirmed cases of St. Louis encephalitis, with an average of 130 cases per year. Up to 3,000 cases have been reported during epidemics in some years. Many more infections occur without symptoms and go undiagnosed.

Is St. Louis encephalitis an emerging infectious disease?

Yes. The virus was first isolated in 1933 during an epidemic in St. Louis, Missouri, and has re-emerged often in epidemics in the United States. The largest outbreaks in 15 years occurred in 1990 in Florida and Texas. The risk of exposure is increasing in urban areas as deteriorating inner cities create new habitats for mosquitoes.

How can St. Louis encephalitis be prevented?

There is no vaccine to prevent St. Louis encephalitis. Prevention centers on public health action to control mosquitoes and on individual action to avoid mosquito bites. To avoid being bitten by the mosquitoes that cause St. Louis encephalitis:

  • If possible, stay inside between dusk and dark. This is when the mosquitoes are most active in their search for food.
  • When outside, wear long pants and long-sleeved shirts.
  • Spray exposed skin with insect repellent.

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