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Ms. Schmidt is an applied mathematician in the Unit on Neuroadaptation and Protein Metabolism in the Laboratory of Cerebral Metabolism of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. She received a M.A. in mathematics from the University of Maryland where she studied numerical linear algebra with G.W. Stewart. She joined the Laboratory of Cerebral Metabolism in 1983 to work with Louis Sokoloff on quantitative in vivo imaging techniques. Ms. Schmidt's current work centers on the development and analysis of kinetic models of tracers used for the measurement of regional cerebral blood flow, glucose metabolism, and protein synthesis by Positron Emission Tomography (PET) and quantitative autoradiographic techniques. |
Schmidt KC, Cook MP, Qin M, Kang J, Burlin TV, Smith CB. Measurement of regional rates of cerebral protein synthesis with L-[1-C11]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach. .J Cereb Blood Flow Metab 2005, 25:617-628 [pdf].
Smith CB, Schmidt KC, Qin M, Burlin TV, Cook MP, Kang J, Saunders RC, Bacher JD, Carson RE, Channing MA, Eckelman WC, Herscovitch P, Laverman P, Vuong B-K. Measurement of regional rates of cerebral protein synthesis with L-[1-C11]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys. J Cereb Blood Flow Metab 2005, 25:629-640 [pdf].
Shimoji K, Ravasi L, Schmidt K, Soto-Montenegro ML, Esaki T, Seidel J, Jagoda E, Sokoloff L, Green MV, Eckelman WC. Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling. J Nucl Med 2004, 45:665-672 [pdf].
Schmidt K. Can normalized tissue activities be used instead of absolute blood flow measurements in the brain? Eur J Nucl Med 2002, 29:953-956 [pdf].
Schmidt KC, Turkheimer FE. Kinetic modeling in positron emission tomography. Q J Nucl Med 2002, 46:70-85.
Schmidt KC, Sokoloff L. A computationally efficient algorithm for determining regional cerebral blood flow in heterogeneous tissues by positron emission tomography. IEEE Transactions on Medical Imaging 2001, 20(7):618-632 [pdf].
Turkheimer FE, Smith CB, Schmidt K. Estimation of the number of "true" null hypotheses in multivariate analysis of neuroimaging data. Neuroimage 2001, 13:920-930 [pdf].
Schmidt K. Which linear compartmental systems can be analyzed by spectral analysis of PET output data summed over all compartments? J Cereb Blood Flow Metab 1999, 19:560-569.
Address: Building 10, Room 2D56, 10 Center Drive, Bethesda, MD 20892-1298
Phone: 301-402-3119
Email: Email Ms. Schmidt
Fax: 301-480-1668
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