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Dr. Smith is Chief of the Unit on Neuroadaptation and Protein Metabolism in the Laboratory of Cerebral Metabolism of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. Dr. Smith received a Ph.D. from the University of London where she studied the chemical pathology of Alzheimer's Disease with David Bowen, for which she was awarded the Queen Square Prize. She did postdoctoral training with Louis Sokoloff at NIMH and in 1986 became a Senior Investigator within the Laboratory of Cerebral Metabolism, NIMH. In 2000 Dr. Smith was awarded an honorary degree from the University of Linkõping for her work developing an in vivo quantitative autoradiographic method for regional rates of |
| cerebral protein synthesis in experimental animals. Dr. Smith's group recently adapted this method for use in man with Positron Emission Tomography. Her group is currently studying mechanisms underlying brain dysfunction in genetic mouse models of inherited forms of mental retardation. |
Smith CB, Deibler GE, Eng N, Schmidt K, Sokoloff L. Measurement of local cerebral protein synthesis in vivo: Influence of recycling of amino acids derived from protein degradation. Proc Natl Acad Sci USA 1988, 85:9341-9345 [pdf].
Smith CB, Crane AM, Kadekaro M, Agranoff BW, Sokoloff L. Stimulation of protein synthesis and glucose utilization in the hypoglossal nucleus induced by axotomy. J Neurosci 1984:4:2489-2496 [pdf].
Kennedy C, Suda S, Smith CB, Miyaoka M, Ito M, Sokoloff L. Changes in protein synthesis underlying functional plasticity in immature monkey visual system. Proc Natl Acad Sci USA 1981, 78:3950-3953 [pdf].
Sun Y, Deibler GE, Jehle J, Macedonia J, Dumont I, Dang T, Smith, CB. Rates of local cerebral protein synthesis in the rat during normal postnatal development. Am J Physiol 1995, 268:R549-R561 [pdf].
Smith CB, Sun Y, Sokoloff L. Effects of aging on regional rates of cerebral protein synthesis in the Sprague-Dawley rat - examination of the influence of recycling of amino-acids derived from protein degradation into the precursor pool. Neurochem Internl 1995, 27:407-416 [pdf].
Frerichs KU, Smith CB, Brenner M, DeGracia DJ, Krause GS, Marrone L, Dever TE, Hallenbeck JM. Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation. Proc Natl Acad Sci USA 1998, 95:14511-14516 [pdf].
Qin M, Kang J, Burlin TV, Jiang C, Smith CB. Postadolescent changes in regional cerebral protein synthesis: an in vivo study in the Fmr1 null mouse. J Neuroscience 2005, 25(20):5087-5095 [pdf].
Smith CB, Kang J. Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc Natl Acad Sci USA 2000, 97:11014-11019 [pdf].
Schmidt KC, Cook MP, Qin M, Kang J, Burlin TV, Smith CB. Measurement of regional rates of cerebral protein synthesis with L-[1-C11]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach. .J Cereb Blood Flow Metab 2005, 25:617-628 [pdf].
Smith CB, Schmidt KC, Qin M, Burlin TV, Cook MP, Kang J, Saunders RC, Bacher JD, Carson RE, Channing MA, Eckelman WC, Herscovitch P, Laverman P, Vuong B-K. Measurement of regional rates of cerebral protein synthesis with L-[1-C11]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys. J Cereb Blood Flow Metab 2005, 25:629-640 [pdf].
Address: Building 10, Room 2D56, 10 Center Drive, Bethesda, MD 20892-1298
Phone: 301-402-3120
Email: Email Dr. Smith
Fax: 301-480-1668
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