Steps 1–3a show the usual way in which the information on a DNA strand serves as a blueprint for generating proteins. In antisense RNA treatment (3b), a 'dummy' sequence of DNA prevents ribosomes from carrying out the process of making proteins. Using this technique researchers may be able to investigate the link between genes and alcohol-related problems. For example, certain proteins may be needed to manufacture neurotransmitters involved in the desire to consume alcohol; if blocking the creation of one of those proteins would change alcohol consumption, the gene(s) responsible for making that protein might be involved in the urge to drink alcohol.

Source: Hiller-Strumhofel, S., et al. Genetic engineering in animal models. Alcohol Health & Research World 19(3):206–213, 1995.

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Prepared: February 2001