This program area, directed by Dr. Charisee Lamar, supports research dealing with the central mechanisms governing ovulation and gametogenesis. Emphasis is placed on the cellular, molecular and genetic mechanisms underpinning the neuroendocrine control of reproduction including sexual behavior and function. Recent interest has centered on the cellular and molecular events controlling pulsatile secretion of gonadotropin-releasing hormone (GnRH), novel forms and functions of GnRH and its receptor, neuron-glial interactions important in regulating GnRH, the cellular and molecular mechanisms underlying differential secretion of gonadotropin by single gonadotropes, and the interactions between the neuroendocrine and immune axes. Also of interest is the emerging role of membrane receptors in mediating the effects of steroids on the neuroendocrine reproductive axis.
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