SUNDAY, Aug. 3 (HealthDay News) -- New guidelines for treating HIV and AIDS patients with treatments known as antiretrovirals suggest earlier therapy might be effective.
The findings were slated to be presented at the International AIDS Conference in Mexico City Sunday. They will also appear in the Aug. 6 issue of the Journal of the American Medical Association (JAMA).
The new guidelines were written by the International AIDS Society-USA Panel, and recommend starting therapy before immune-system CD4 cell counts decline to less than 350 cells per microliter. Additional factors should be considered when starting therapy at higher CD4 levels.
"As we now have developed treatments that are easier to take in terms of number of pills, number of doses in the day and potential adverse effects, and we now know there seem to be additional benefits with starting earlier, the pendulum is swinging back to starting [treatment] earlier," noted Dr. Michael Horberg, director of HIV/AIDS policy at Kaiser Permanente Health Plan in Santa Clara, Calif. "Also, importantly, is the recognition of comorbidities that should prompt you to start treatment earlier, including hepatitis B or C, cardiovascular risk, and HIV-associated necropathy."
The authors of the guidelines also recommended that frontline regimens be individualized, and that certain drugs such as Sustiva (efavirenz) be given high consideration.
Patient plasma HIV-1 RNA levels should be monitored regularly, and genotypic testing for drug resistance also should be performed for certain patients.
The guidelines also addressed changing therapies and when to introduce new drugs.
In other news from the AIDS conference:
"The take-home message is 'prevention is always better than treatment,' which seems to be possible through the utilization of the latest diagnostic techniques," said Srikanth Kolluru, an assistant professor of pharmaceutical sciences at Texas A&M Health Science Center Irma Lerma Rangel College of Pharmacy in Kingsville.
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Date last updated: 04 August 2008 |