| 8:30 - 9:00 a.m. | Welcome & Introductions
NIH Directors
Duane Alexander, NICHD
Kenneth Olden, NIEHS
Steven Hyman, NIMH
Audrey Penn, NINDS
James Battey, NIDCD
Overview
Conference Co-Chairs
Jean Lauder, University of North Carolina
Marie Bristol Power, NICHD
Cindy Lawler, NIEHS
|
Autism and Related Disorders
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| 8:50 - 9:00 a.m. | Overview |
| 9:00 -10:20 a.m. | Session 1: Neuropathology of Autism: Chair, Anthony Bailey
Neuroanatomical Correlates of Autism
Anthony Bailey |
| | Dysregulation of Reelin Protein in Autism
S. Hossein Fatemi |
| | Cerebellar Neuropathology and Autistic Behaviors: Exploration of a Mouse Model System
Daniel Goldowitz |
| | Reduced Number of Benzodiazepine Binding Sites and Decreased Density of GABAA Receptors in Hippocampal Formation of Autistic Individuals
Gene J. Blatt |
| 10:20 - 10:35 a.m. | Discussion |
| 10:35-10:50 a.m. | Coffee Break
Sponsored by the ASA Foundation |
| 10:50 - 11:30 a.m. | Session 2: Cognitive and Social Phenotypes in Autism: Chair, Joseph Piven
Human Research |
| | Social Intelligence in Normal and Autistic Brain
Helen Tager-Flusberg |
| | fMRI Evidence for Differences in Social Affective Processing in Autism
Robert Schultz |
| 11:30 - 11:45 a.m. | Discussion |
| 11:45 - 1:00 a.m. | Working Lunch |
| 1:00 - 2:00 a.m. | Animal Models
Social Interaction Abnormalities in Mice Lacking Dvl1
Anthony Wynshaw-Boris |
| | Social Deficits in Oxytocin Knockout Mice
Larry Young |
| | The Primate Temporal Lobe Structures: Maturation, Early Dysfunction, and Relationships to Human Developmental Disorders
Jocelyne Bachevalier |
| 2:00 - 2:15 p.m. | Discussion |
| 2:15 - 3:15 p.m. | Session 3: Molecular Genetics of Autism: Chair, Edwin Cook |
| | Functional and Positional Candidate Gene Studies of Autism
Edwin Cook |
| | Evidence Supporting Wnt2 as an Autism Susceptibility Gene
Thomas Wassink |
| | Rett Syndrome, MECP2 Mutations, and Autism
Ignatia Van den Veyver |
| 3:15 - 3:30 p.m. | Break |
| 3:30 - 4:30 p.m. | Cellular Substrates of Fragile X Syndrome
William T. Greenough |
| | Brain Abnormalities in a Mouse Model for Smith-Lemli-Opitz Syndrome: Implications for Autism
Heather Baudet and Kathy Sulik |
| | Ch 15q 22-23 Deletion in Autism and Evidence for Location of Two Series of Chromosome 15 Specific Duplicons that Predispose to Chromosome Rearrangements
Moyra Smith |
| 4:30 - 4:45 p.m. | Discussion |
| 4:45 - 5:00 p.m. | General Discussion |
| 6:30 p.m. | Working Dinner (Session chairs and speakers only - reports) |
| ________________________________________________________________ |
| September 7, 2001 |
| 8:00-9:40 a.m. | Session 4: Neurotransmitters Systems in Autism: Chair, Jean Lauder |
| | Abnormal Serotonin Synthesis and GABAA Receptors Measure with PET in Autistic Children
Diane C. Chugani |
| | Prenatal Serotonin in Rats as an Animal Model of Autism
Patricia Whitaker-Azmitia |
| | Chronic Elevation of Serotonin and Norepinephrine in MAO-A and MAO-A/B Deficient Mice
Daniel Holschneider |
| | Control of Central Serotonergic Neuron Phenotype by the ETS Domain Factor PET-1
Evan Deneris |
| | Characteristics of Mice Lacking the gabrb3 Gene
Timothy DeLorey |
| 9:40 - 9:55 a.m. | Discussion |
| 9:55 -10:10 a.m. | Break
|
Role of the Environment in Autism
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| 10:10 - 12:10 a.m. | Session 5: Environmental Influences as Etiologic Factors in Autism: Chair, Stanley Barone |
| | Developing Neurotransmitter Systems as Targets for Pesticide Exposure
Jean Lauder |
| | Environmental Insults and Early Developmental Genes in Autism Etiology
Patricia Rodier |
| | Regulation of Neurogenesis by Growth Factors and Neurotoxicants
Emanuel DiCicco-Bloom |
| | Disruption of Synaptic Neural Cell Adhesion Molecules by Environmental Insults
Kenneth Reuhl |
| | Multidisciplinary Analysis of the BDV Animal Model of Autism: Neuroanatomical, Neurochemical, Behavioral, and Genetic Features
Mikhail Pletnikov |
| | Possible Environmental Risk Factors in the Etiology of Autism
Isaac Pessah |
| 12:10 - 12:25 a.m. | Discussion |
| 12:25 - 1:20 a.m. | Working Lunch
Sponsored by the Autism Tissue Program
|
Emerging Technologies and Strategies in Autism Research
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| 1:20 - 2:40 p.m. | Session 6: Emerging Technologies: Chair, Clarence Schutt |
| | Gene-based Mutagenesis for Functional Annotation in the Mouse
Terry Magnuson |
| | Metabonomics
Jeremy Nicholson |
| | Microdissection and Laser Capture Micromanipulation
Chi'ming Huang |
| | Structural Biology in Autism Research
Clarence Schutt |
| 2:40 - 2:55 p.m. | Discussion |
| 2:55 - 3:10 p.m. | Coffee Break
Sponsored by the National Association for Autism Research (NAAR) |
| 3:10 - 4:00 p.m. | Session 7: Autism Brain Tissue Panel-Progress and Future Strategies: Chair, Jane Pickett |
| | Brain and Tissue Donation - Issues Related to Children
Ronald Zielke |
| | Neuropathology
Margaret Bauman |
| | Microarrays in Human Tissue/Tuberous Sclerosis/Seizures
Peter Crino |
| | Tissue Based Data Warehousing to Maximize Collaboration by Divergent Laboratories
Harry Haroutunian |
| | Immunohistochemistry
Robert Lopez |
| 4:00 - 4:15 p.m. | Discussion |
| 4:15 - 4:40 p.m. | Reports of Recommendations from Working Groups |
| 4:40 - 5:00 p.m. | Discussion of Reports from Working Groups
|
We would like to thank Jack Bishop, William McMahon, and Ute Schambra for serving as conference discussants
We would like to thank the Autism Tissue Program, The National Association for Autism Research (NAAR), and the ASA Foundation for sponsoring the refreshments for this conference. |
