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- New Details in Schizophrenia Treatment Trial Emerge
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March 1, 2007
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Press Release
Two new studies from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) provide more insights into comparing treatment options, and to what extent antipsychotic medications help people with schizophrenia learn social, interpersonal and community living skills.
- Landmark Council Session Spotlights “Real World” Trials
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December 21, 2006
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Science Update
Principal investigators of NIMH's four large-scale clinical trials presented study results and their implications at the National Advisory Mental Health Council meeting on September 15, 2006.
- Older Medication May Be More Cost-Effective for Some Patients with Schizophrenia
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December 1, 2006
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Press Release
A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting that older antipsychotics still have a role in treating schizophrenia.
- New NIMH Research Strives to Understand How Antidepressants May Be Associated with Suicidal Thoughts and Actions
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November 13, 2006
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Science Update
The National Institute of Mental Health (NIMH), part of the National Institutes of Health, is funding five new research projects that will shed light on antidepressant medications, notably selective serotonin reuptake inhibitors (SSRIs), and their association with suicidal thoughts and actions.
- Odds of Beating Depression Diminish as Additional Treatment Strategies are Needed
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November 1, 2006
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Science Update
An overall assessment of the nation's largest real-world study of treatment-resistant depression suggests that a patient with persistent depression can get well after trying several treatment strategies, but his or her odds of beating the depression diminish as additional treatment strategies are needed.
- Antipsychotic Medications Used to Treat Alzheimer’s Patients Found Lacking
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October 11, 2006
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Press Release
Commonly prescribed antipsychotic medications used to treat Alzheimer’s patients with delusions, aggression, hallucinations, and other similar symptoms can benefit some patients, but they appear to be no more effective than a placebo when adverse side effects are considered, according to the first phase of a large-scale clinical trial funded by NIMH.
- New Schizophrenia Trial: Does Method of Administering Medication Make a Difference?
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September 5, 2006
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Science Update
A new clinical trial is testing whether an injection of a long-lasting antipsychotic medication every two weeks results in better adherence to treatment and better outcomes among people with schizophrenia than do oral medications taken daily.
- Subsequent Treatment Strategies for Persistent Depression Yield Modest Results
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September 1, 2006
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Science Update
Patients with treatment-resistant depression had a modest chance of becoming symptom-free when they tried different treatment strategies after two or three failed treatments, according to results from the nation's largest real-world study of depression.
- Brain Changes Mirror Symptoms in ADHD
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July 19, 2006
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Science Update
The severity of attention deficit hyperactivity disorder (ADHD) symptoms in youth appears to be reflected in their brain structure, recent NIMH-supported brain imaging studies are finding.
- New Factors Identified for Predicting Violence in Schizophrenia
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July 18, 2006
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Science Update
A study of adults with schizophrenia showed that symptoms of losing contact with reality, such as delusions and hallucinations, increased the odds of serious violence nearly threefold.
