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Role of NFkB and p44/42 pathways in lipopolysaccharide-induced increase of anandamide synthesis in RAW264.7 macrophages



The illustration below was presented XIV World Congress of Pharmacology July 7-12, 2002

Role of NFkB and p44/42 pathways in lipopolysaccharide-induced increase of anandamide synthesis in RAW264.7 macrophages

In RAW264.7 macrophages LPS induces the synthesis of anandamide, but not 2-AG, via a transcriptional mechanism independent of PAF that involves NFkB and the p44/42 signaling pathways and most likely targets a NAPE-specific phospholipid D (PLD).



Updated: August 2002

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