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Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis



The illustration below is from Vol 7 pp. 827-32, 2001 of Nature Medicine

Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis

Endogenous anandamide in monocytes from cirrhotic and control rats. A representative LC/MS analysis of samples extracted from the monocyte fraction of 20 ml pooled blood of sham-operated (a) and cirrhotic (b) rats. Two selected ions were monitored simultaneously: m/z 356.2 for d8-anandamide ions as internal standard (upper panels) and m/z 348.2 for anandamide ions (bottom panels). Numbers at the peaks indicate the Liquid chromatography (LC) retention time of the compounds in minutes.



Updated: August 2002

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