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Brief Summary

GUIDELINE TITLE

Acute seizures and seizure disorder.

BIBLIOGRAPHIC SOURCE(S)

  • Texas Tech University Managed Health Care Network Pharmacy & Therapeutics Committee. Acute seizures and seizure disorder. Conroe (TX): University of Texas Medical Branch Correctional Managed Care; 2003 Apr. 4 p. [6 references]

GUIDELINE STATUS

This is the current release of the guideline.

This guideline updates a previous version: Texas Tech University Managed Health Care Network Pharmacy & Therapeutics Committee. Acute seizures and seizure disorders. Conroe (TX): Texas Department of Criminal Justice, University of Texas Medical Branch; 1998 Mar. 4 p.

** REGULATORY ALERT **

FDA WARNING/REGULATORY ALERT

Note from the National Guideline Clearinghouse: This guideline references a drug(s) for which important revised regulatory and/or warning information has been released.

  • December 12, 2007, Carbamazepine: The U.S. Food and Drug Administration (FDA) has provided recommendations for screening that should be performed on specific patient populations before starting treatment with carbamazepine.

BRIEF SUMMARY CONTENT

 ** REGULATORY ALERT **
 RECOMMENDATIONS
 EVIDENCE SUPPORTING THE RECOMMENDATIONS
 IDENTIFYING INFORMATION AND AVAILABILITY
 DISCLAIMER

 Go to the Complete Summary

RECOMMENDATIONS

MAJOR RECOMMENDATIONS

The major recommendations are provided in the form of algorithms for: Acute Seizures and Seizure Disorder.

Seizure Disorder

Most Commonly Used Drugs for Specific Seizure Disorders

Begin treatment with single drug using recommended initial daily dosing. Up to 80% of patients can be managed with monotherapy. Ensure proper medication adherence prior to modifying regimen. Refer to the original guideline document for formulary and non-formulary agents used in the treatment of seizure disorders.

Monitoring Parameters for Formulary Anticonvulsant Medications

Carbamazepine

  • Complete blood count (CBC) with platelets at baseline, then twice monthly first two months, and annually or as clinically indicated
  • Blood chemistries with emphasis on hepatic and renal function and electrolytes at baseline, then at one month, and annually or as clinically indicated
  • Electrocardiogram (EKG) at baseline for patients >40 years old and as clinically indicated
  • Carbamazepine level weekly for two weeks, then at one month and annually or as clinically indicated

Phenytoin

  • CBC at baseline and as clinically indicated
  • Blood chemistries with emphasis on hepatic and renal functions at baseline, annually and as clinically indicated
  • EKG at baseline for patients >40 years old and as clinically indicated
  • Phenytoin level in one week, then in one month, and annually or as clinically indicated

Valproic Acid

  • CBC with platelets at baseline, then twice monthly first two months, and annually or as clinically indicated
  • Blood chemistries with emphasis on hepatic function at baseline, then at one month, and annually or as clinically indicated
  • Protime, international normalized ratio (INR), partial prothrombin time (PPT) at baseline and annually
  • Valproic acid level weekly for two weeks, then annually or as clinically indicated

CLINICAL ALGORITHM(S)

Algorithms are provided for:

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EVIDENCE SUPPORTING THE RECOMMENDATIONS

TYPE OF EVIDENCE SUPPORTING THE RECOMMENDATIONS

The guideline was adapted from the following sources:

McAuley JW, Biederman TS, Smith JC, Moore JL. Newer therapies in the treatment of epilepsy. Ann Pharmacother 2002; 36:119-29.

Anderson GD, Miller JW. The newer antiepileptic drugs: Their collective role and defining characteristics. Formulary. 2001; 36:114-31.

Baker GA, Camfield P, et al. Commission on the outcome measurement in epilepsy, 1994-1997: final report. Epilepsia. 1998: 39:213-31.

Quality Standards Subcommittee of AAN. Practice parameter: a guideline for discontinuing antiepileptic drugs in seizure-free patients – summary statement. Neurology. 1996: 47:600-2.

Working Group on Status Epilecticus, Treatment of Convulsive Status Epilecticus. JAMA. 1993; 270:854-859

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IDENTIFYING INFORMATION AND AVAILABILITY

BIBLIOGRAPHIC SOURCE(S)

  • Texas Tech University Managed Health Care Network Pharmacy & Therapeutics Committee. Acute seizures and seizure disorder. Conroe (TX): University of Texas Medical Branch Correctional Managed Care; 2003 Apr. 4 p. [6 references]

ADAPTATION

The guideline was adapted from the following sources:

McAuley JW, Biederman TS, Smith JC, Moore JL. Newer therapies in the treatment of epilepsy. Ann Pharmacother 2002; 36:119-29.

Anderson GD, Miller JW. The newer antiepileptic drugs: Their collective role and defining characteristics. Formulary. 2001; 36:114-31.

Baker GA, Camfield P, et al. Commission on the outcome measurement in epilepsy, 1994-1997: final report. Epilepsia. 1998: 39:213-31.

Quality Standards Subcommittee of AAN. Practice parameter: a guideline for discontinuing antiepileptic drugs in seizure-free patients – summary statement. Neurology. 1996: 47:600-2.

Working Group on Status Epilecticus, Treatment of Convulsive Status Epilecticus. JAMA. 1993; 270:854-859

DATE RELEASED

1998 Mar (revised 2003 Apr)

GUIDELINE DEVELOPER(S)

University of Texas Medical Branch Correctional Managed Care - Academic Institution

SOURCE(S) OF FUNDING

University of Texas Medical Branch Correctional Managed Care

GUIDELINE COMMITTEE

Texas Tech University Managed HealthCare Network Pharmacy & Therapeutics Committee

COMPOSITION OF GROUP THAT AUTHORED THE GUIDELINE

Not stated

FINANCIAL DISCLOSURES/CONFLICTS OF INTEREST

Not stated

GUIDELINE STATUS

This is the current release of the guideline.

This guideline updates a previous version: Texas Tech University Managed Health Care Network Pharmacy & Therapeutics Committee. Acute seizures and seizure disorders. Conroe (TX): Texas Department of Criminal Justice, University of Texas Medical Branch; 1998 Mar. 4 p.

GUIDELINE AVAILABILITY

Print copies: Available from University of Texas Medical Branch (UTMB), 3009A HWY 30 West, Huntsville, TX, 77340.

AVAILABILITY OF COMPANION DOCUMENTS

None available

PATIENT RESOURCES

None available

NGC STATUS

This summary was updated by ECRI on April 21, 2004. This summary was updated by ECRI on November 16, 2006, following the FDA advisory on Lamictal (lamotrigine). This summary was updated by ECRI Institute on January 10, 2008, following the U.S. Food and Drug Administration advisory on Carbamazepine.

COPYRIGHT STATEMENT

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions.

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DISCLAIMER

NGC DISCLAIMER

The National Guideline Clearinghouse™ (NGC) does not develop, produce, approve, or endorse the guidelines represented on this site.

All guidelines summarized by NGC and hosted on our site are produced under the auspices of medical specialty societies, relevant professional associations, public or private organizations, other government agencies, health care organizations or plans, and similar entities.

Guidelines represented on the NGC Web site are submitted by guideline developers, and are screened solely to determine that they meet the NGC Inclusion Criteria which may be found at http://www.guideline.gov/about/inclusion.aspx .

NGC, AHRQ, and its contractor ECRI Institute make no warranties concerning the content or clinical efficacy or effectiveness of the clinical practice guidelines and related materials represented on this site. Moreover, the views and opinions of developers or authors of guidelines represented on this site do not necessarily state or reflect those of NGC, AHRQ, or its contractor ECRI Institute, and inclusion or hosting of guidelines in NGC may not be used for advertising or commercial endorsement purposes.

Readers with questions regarding guideline content are directed to contact the guideline developer.
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