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Cartoon grantee reading PHS 398If you are a principal investigator planning to use live, vertebrate animals for research, research training, or biological testing, you must adhere to requirements in the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals and the Animal Welfare Act and Regulations.

The PHS policy is summarized in the brochure What Investigators Need to Know About the Use of Animals.

Peer reviewers will evaluate your application based on your compliance, so it's important to know what's expected of you and your institution.

When you apply for NIAID funding, you need answer all five points in the Vertebrate Animals Section of your Grant Application Package (for electronic applications) or your PHS 398 (for paper applications). Most grant types, including research grants such as the R01 and Exploratory/Developmental Grant -- R21, use electronic application, but training (T), career (K), and fellowship (F) grants still use paper forms.

Go to our NIH Grant Cycle: Application to Renewal for beginning-to-end, step-by-step information about applying for the most common grant types.

If your application receives a fundable priority score, have your animal use protocol reviewed and approved by an institutional animal care and use committee (IACUC), which evaluates your institution's animal research program.

To receive an award, you must have IACUC approval, and your institution must have an animal welfare assurance approved by the NIH Office of Laboratory Animal Welfare. If you have subaward agreements, those organizations also need IACUC approval and an animal assurance.

To find out if your institution is assured, see Domestic Institutions with a PHS Approved Animal Welfare Assurance or Foreign Institutions with a PHS Approved Animal Welfare Assurance on the OLAW Web site. Assurances must be renewed every four years.

It's also a good idea to find out if your institution has animal facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care. AAALAC is a non-regulatory organization; participation in its accreditation program sends the message that your institution is committed to high-quality animal care and use.

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