Principal investigator: Richard J. Levine, M.D., M.P.H., M.S.
Dr. Levine is using the database and specimen repository from the trial of Calcium for Preeclampsia Prevention to evaluate the relationship of angiogenic factors to the pathogenesis of preeclampsia and their potential utility for identification of women at high risk of developing preeclampsia. Several important studies are underway.
 
DESPR Collaborators

· Kai F. Yu, Ph.D.
· James L. Mills, M.D., M.S.

Selected Publications

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R,  & Karumanchi SA. (2006). Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992-1005. [Abstract]

Signore C, Mills JL, Qian C, Yu K, Lam C, Epstein FH, Karumanchi SA, & Levine RJ. (2006). Circulating angiogenic factors and placental abruption. Obstetrics & Gynecology, 108:338-344. [Abstract]

Levine RJ, Qian C, Maynard SE, Yu KF, Epstein FH, & Karumanchi SA. (2006). Serum sFlt1 concentration during preeclampsia and midtrimester blood pressure in healthy nulliparous women. Am J Obstet Gynecol , 4:1034-1041. [Abstract]

Levine RJ, Thadhani R, Qian C, Lam C, Lim KH, Yu KF, Blink AL, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, & Karumanchi SA. (2005). Urinary placental growth factor and the risk of preeclampsia. JAMA, 293:77-85. [Abstract]

Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani RI, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, & Karumanchi SA. (2004). Circulating angiogenic factors and the risk of preeclampsia. New Engl J Med, 350:672-683. [Abstract]

Levine RJ, Qian C, LeShane ES, Yu KF, England LJ, Schisterman EF, Wataganara T, Romero R, & Bianchi DW. (2004). Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am J Obstet Gynecol, 190:707-713. [Abstract]

England LJ, Levine RJ, Qian C, Soule LM, Schisterman EF, Yu KF, & Catalano PM. (2004). Glucose tolerance and risk of gestational diabetes in nulliparous women who smoke during pregnancy. Am J Epidem, 160(12):1205-1213. [Abstract]

England LJ, Levine RJ, Mills JL, Klebanoff MA, Yu KF, & Cnattingius S. (2003). Adverse pregnancy outcomes in snuff users. Am J Obstet Gynecol, 189:939-943. [Abstract]

Saftlas AE, Levine RJ, Martz KL, Ewell MG, Sibai BM, Morris CD, & Klebanoff MA. (2003). Abortion, changed paternity, and risk of preeclampsia in nulliparous women. Am J Epidem, 157:1108-1114. [Abstract]

Regan CL, Levine RJ, Baird DD, Ewell MG, Martz KL, Sibai BM, Lawson JA, & FitzGerald GA. (2001). No evidence for lipid peroxidation in severe preeclampsia. Am J Obstet Gynecol, 185:572-578. [Abstract]

Morris CD, Jacobson SL, Anand R, Ewell MG, Curet LB, Catalano PM, Sibai BM, Hauth JC, & Levine RJ. (2001). Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort. Am J Obstet Gynecol, 184:643-651. [Abstract]

Cohen GR, Curet LB, Levine RJ, Ewell MG, Morris CD, Catalano PM, Clokey D, & Klebanoff MA. (2001). Ethnicity, nutrition and birth outcomes in nulliparous women. Am J Obstet Gynecol, 185:660-667. [Abstract]

Hauth JC, Ewell MG, Levine RJ, Esterlitz JR, Sibai B, Curet LB, Catalano PM, & Morris CD. (2000). Pregnancy outcomes in healthy nulliparas who developed hypertension: Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol, 95:24-28 [Abstract]

DerSimonian R & Levine RJ. (1999). Resolving discrepancies between a meta-analysis and a subsequent large controlled trial. JAMA, 282:664-670. [Abstract]

Mills JL, DerSimonian R, Raymond E, Morrow JD, Roberts LJ, Clemens JD, Hauth JC, Catalano P, Sibai B, Curet LB, & Levine RJ. (1999). Prostacyclin and thromboxane changes antedating clinical onset of preeclampsia: A multicenter prospective study. JAMA, 282:356-362. [Abstract]