Moye J, Frederick M, Chantry C, Handelsman E, Trupin D, Paul M, Adeniyi-Jones S; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 8th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 8th 2001 Chic Ill. 2001 Feb 4-8; 8: 197 (abstract no. 514).
NICHD.
Background: HIV infection adversely affects growth in infants with perinatally acquired and older children with transfusion acquired disease. Little data exist on its later effects on growth in perinatally acquired disease or with chronic antiretroviral treatment. Objectives: To compare attained growth and body composition in infected and uninfected subjects in a large prospective cohort study of children born to HIV infected women. Methods: 187 infected and 1607 uninfected children were studied. The overall proportions of infected children by treatment were as follows: receiving zidovudine, 86%; receiving dual combination antiretrovirals, 69%; and receiving antiproteases, 42%. Routine anthropometric measurements were made by trained examiners, beginning in 1989, at least every 6 months through age 10 years. Bioimpedance, skinfold, and limb circumference measures were added in 1998. Mean values were compared by F-test. Results: [table: see text] Conclusions: HIV infected children show persistent and in some cases increasing deficits in measures of attained growth despite antiretroviral treatment. Measures of body composition show similar trends and warrant ongoing study.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Child
- Cohort Studies
- Disease Progression
- Female
- Growth
- HIV Infections
- HIV Seropositivity
- Humans
- Infant
- Longitudinal Studies
- Prospective Studies
- Zidovudine
Other ID:
UI: 102244297
From Meeting Abstracts