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Selected Publications

Photochemistry/Photobiology

  1. Chignell, C.F. and Sik, R.H. A photochemical study of cells loaded 2',7'-dichlorofluorescin: Implications for the detection of reactive oxygen species generated during UVA irradiation. Free Rad. Biol. Med., 34:1029-1034 (2003).  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12684087) Exit NIEHS
  2. Inbaraj, J.J., Motten, A.G. and Chignell, C. F. Photochemical and photobiological studies of Tirapazamine (SR 4233) and related quinoxaline 1,4-di-N-oxide analogs. Chem Res. Toxicol., 16:164-170, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12588187) Exit NIEHS
  3. He, Y-Y, Huang, J-L, Ramirez, D.C. and Chignell, C. F. Role of Reduced Glutathione Efflux in Apoptosis of Immortalized Human Keratinocytes Induced by UVA, J. Biol Chem., 278:8058-8064, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12502708) Exit NIEHS
  4. Chignell, C.F., Haseman, J.K., Sik, R.H., Tennant, R.W. and Trempus, C.S. Photocarcinogenesis in the Tg.AC mouse: Lomefloxacin and 8-methoxypsoralen, Photochem. Photobiol., 77:77-80, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12856886) Exit NIEHS
  5. He, Y-Y, Ramirez, D.C., Detweiler, C.D., Mason, R.P. and Chignell, C. F. UVA/Ketoprofen-induced hemoglobin radicals detected by Immuno-Spin Trapping. Photochem. Photobiol., 77: 585-591, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12870842) Exit NIEHS
  6. Bilski, P., Hideg, K., Kalai, T., Bilska, M.A., Chignell, C.F. Interaction of singlet molecular oxygen with double fluorescent and spin sensors. Free Rad. Biol. & Med. 34: 489-495, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12566074) Exit NIEHS
  7. He Y-Y, Huang, J-L., Sik, R.H., Liu, J., Waalkes, M.P. and Chignell, C. F. Expression profiling of human keratinocyte response to ultraviolet A: Implications in apoptosis. J.Invest. Dermatol. 122: 533-543, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15009741) Exit NIEHS
  8. He, Y-Y, Huang, J-L., Gentry, J. B. and Chignell, C.F. EGF receptor kinase activity is not required for UVA-induced the receptor down-regulation. J. Biol Chem. 278: 42457-42465, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12930839) Exit NIEHS
  9. Matuszak, Z., M. Bilska, A., Reszka, K. J., Chignell, C. F. and Bilski, P. Interaction of Singlet Molecular Oxygen with Melatonin and Related Indoles. Photochem. Photobiol., 78: 449–455, 2003.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14653575) Exit NIEHS
  10. Inbaraj, J.J. and Chignell, C.F. Cytotoxic action of juglone and plumbagin: A mechanistic study using HaCaT keratinocytes. Chem. Res. Toxicol., 17:55-62, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14727919) Exit NIEHS
  11. He, Y-Y, Huang, J-Li and Chignell, C.F. Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA - Implications in carcinogenesis, J. Biol. Chem. 279: 53867-53874, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15471881) Exit NIEHS
  12. He,Y-Y., Chignell,C.F., Miller,D.S., Andley, U.P. and Roberts, J.E. Phototoxicity in Human Lens Epithelial Cells Promoted by St. John’s Wort, Photochem. Photobiol. 80: 583–586, 2004.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15623347) Exit NIEHS
  13. Inbaraj, J.J., Kukielczak, B.K. and Chignell, C.F. Phloxine B phototoxicity: A mechanistic study using HaCaT keratinocytes, Photochem. Photobiol. 81: 81-88, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15473832) Exit NIEHS
  14. He Y-Y, Huang J-L, Block M.L., Hong J.S., Chignell C.F. Role of Phagocyte Oxidase in UVA-Induced Oxidative Stress and Apoptosis in Keratinocytes, J. Invest. Dermatol. 125:560-6, 2005.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16117799) Exit NIEHS
  15. He Y-Y, Huang J-L and Chignell C.F. Cleavage of epidermal growth factor receptor by caspase is independent of its internalization, Oncogene 25: 1521-1531, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16247443) Exit NIEHS
  16. He, Y-Y, Pi J, Huang J-J, Diwan B.A.., Waalkes M. P. and Chignell, C.F. Chronic UVA irradiation of human keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene 25:3680-3688, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16682958) Exit NIEHS
  17. Inbaraj, J.J., Kukielczak, B.M., Bilski, P.J., He, Y-Y., and Chignell, C.F. Photochemistry and Photocytotoxicity of Alkaloids from Goldenseal (Hydrastis canadensis L.) 2. Palmatine, Hydrastine, Canadine and Hydrastinine. Chem. Res. Toxicol., 19:739-744, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16780351) Exit NIEHS
  18. Chignell, C.F., Kukielczak, B.M, Sik, R.H., Bilski, P.J., and He, Y-Y. UVA Sensitivity in Smith-Lemli-Opitz Syndrome: Possible Involvement of Cholesta-5,7,9(11)-trien-3 β-ol. Free Rad. Biol. & Med., 41:339-346, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16814115) Exit NIEHS
  19. Nakai K., Motten A.G., Chignell C.F. An in vivo study of free radicals generated in murine skin by protoporphyrin IX and visible light. Photochem. Photobiol. 82:738-40, 2006.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16522136) Exit NIEHS
  20. Chignell CF , Sik RH , Watson M , Wielgus AR . Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3. Effect on human lens and retinal pigment epithelium cells. Photochemistry and photobiology 4 (938-943), 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17645667) Exit NIEHS
  21. He Y-Y, Council SE, Feng L, Bonini MG, Chignell CF. Spatial distribution of protein damage by singlet oxygen in keratinocytes. Photochemistry and photobiology 84(1):69-74, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18173704) Exit NIEHS
  22. Wiechmann AF, Chignell CF, Roberts JE. Influence of dietary melatonin on photoreceptor survival in the rat retina: An ocular toxicity study. Experimental eye research 86(2):241-250, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18078931) Exit NIEHS
  23. Han S-K, Bilski P , Karriker B, Sik RH, Chignell CF. Oxidation of flame retardant tetrabromobisphenol A by singlet oxygen. Environmental Science and Technology 42(1):166-172, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18350892) Exit NIEHS
  24. He Y-Y, Council SE, Feng L, Chignell CF. UVA-Induced Cell Cycle Progression Is Mediated by a Disintegrin and Metalloprotease/Epidermal Growth Factor Receptor/AKT/Cyclin D1 Pathways in Keratinocytes. Cancer research 68(10):3752-3758, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18483258) Exit NIEHS
  25. Zhao B, He YY, Bilski PJ, Chignell CF. Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: Type I vs. Type II mechanisms. Chemical research in toxicology 21(5):1056-1063, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18422350) Exit NIEHS
  26. Roberts JE, Wielgus AR, Boyes WK, Andley U, Chignell CF. Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells. Toxicology and applied pharmacology 228(1):49-58, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18234258) Exit NIEHS
  27. Chignell CF, Han S-K, Mouithys-Mickalad A, Sik RH, Stadler K, Kadiiska MB. EPR studies of in vivo radical production by 3,3',5,5'-tetrabromobisphenol A (TBBPA) in the Sprague-Dawley rat. Toxicology and applied pharmacology 230(1):17-22, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18342900) Exit NIEHS

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Last Reviewed: September 03, 2008