1. Summary of Proposal Contents

- Field Work Proposal (FWP) Format (Reference DOE Order 5700.7C)
- FWP Proposal Cover Page (lead National Laboratory)
- Table of Contents
- List of all Participating Institutions and the total annual budget for each institutions
- Collaborating Institution Cover Pages (University and/or other National Laboratories)
- Budget and Budget Explanation for the lead institution and each collaborating institution
- Other support of investigators
- Abstract (one page)
- Narrative (includes proposal summary)
- Literature Cited
- Biographical Sketches
- Description of facilities and resources
- Appendix

An original FWP with signatures plus seven copies of signed original FWP must be submitted.

The Narrative section of the proposal must be 40 pages or less exclusive of attachments.

Proposals must be readily legible, when photocopied, and must conform to the following three requirements: the height of the letters must be no smaller than 10 point with at least 2 points of spacing between lines (leading); the type density must average no more than 17 characters per inch; the margins must be at least one-half inch on all sides. Figures, charts, tables, figure legends, etc., may include type smaller than these requirements as long as they are fully legible.

The Field Work Proposal (FWP) from DOE National Laboratories should be prepared and submitted consistent with policies of the investigator's laboratory and the local DOE Operations Office. Additional information is also requested to allow for scientific/technical merit review. Laboratories may submit proposals directly to the SC Program office listed above. A copy should also be provided to the appropriate DOE operations office.

The following proposal cover page information may be placed on plain paper. No form is required.

- Title of proposed project
- SC Program Announcement title
- Name of laboratory
- Name of principal investigator (PI)
- Position title of PI
- Mailing address of PI
- Telephone number of PI
- Fax number of PI
- Electronic mail address of PI
- Name of official signing for laboratory*
- Title of official
- Fax number of official
- Telephone number of official
- Electronic mail address of official
- Requested funding for each year; total request
- Use of human subjects in proposed project:


If activities involving human subjects are not planned at any time during the proposed project period, state "No" otherwise state "Yes", and provide the IRB Approval date, Assurance of Compliance Number, and all other necessary information with the proposal.
- Use of vertebrate animals in proposed project:

If activities involving vertebrate animals are not planned at any time during this project, state "No"; otherwise state "Yes", and provide the IACUC Approval date, Animal Welfare Assurance number from NIH, and all necessary information with the proposal.
- Signature of PI, date of signature
- Signature of official, date of signature*
- List of all participating institutions, the Principal Investigator for each institution, and the total annual budget for each institution.

(*This signature certifies that personnel and facilities are available as stated in the proposal, if the project is funded.)

Provide the initial page number for each of the sections of the proposal. Number pages consecutively at the bottom of each page throughout the proposal. Start each major section at the top of a new page. Do not use unnumbered pages and do not use suffices, such as 5a, 5b.

8. List of Participating Institutions

A list of all participating institutions should include: (1) the name, address, phone number, and e-mail address of the principal investigator, (2) academic affiliation, and (3) the total annual budget for each institution.

9. Collaborating Institution Cover Page(s)

Each non-DOE National Laboratory collaborating institution should submit a separate Face Page (Form DOE F 4650.2). Instructions can be found in the Application Guide for the Office of Science Financial Assistance Program, 10 CFR Part 605. Access to SC's Financial Assistance Application Guide is possible via the World Wide Web at: http://www.sc.doe.gov/production/grants/grants.html. Block 15 of the SC grant face page (form DOE F4650.2) should list the PI’s phone number, fax number, and e-mail address.

10. Budget and Budget Explanation

A detailed budget is required for the overall project and for each collaborative project for the entire project period (up to three years), and for each fiscal year. It is preferred that DOE's budget page, Form 4620.1 be used for providing budget information. Collaborating Universities should use DOE Form 4620.1. Modifications of categories are permissible to comply with institutional practices, for example with regard to overhead costs. A written justification of each budget item is to follow the budget pages. For personnel this should take the form of a one-sentence statement of the role of the person in the project. Provide a detailed justification of the need for each item of permanent equipment. Explain each of the other direct costs in sufficient detail for reviewers to be able to judge the appropriateness of the amount requested. Further instructions regarding the budget submission can be found at Office of Sciences Financial Assistance web site: http://www.sc.doe.gov/production/grants/forms.html.

Salaries and Wages: List the name of the principal investigator and other key personnel and the estimated number of person-months for which DOE funding is requested. Proposers should list the number of postdoctoral associates and other professional positions included in the proposal and indicate the number of full-time- equivalent (FTE) person-months and rate of pay (hourly, monthly or annually). For graduate and undergraduate students and all other personnel categories such as secretarial, clerical, technical, etc., show the total number of people needed in each job title and total salaries needed. Salaries requested must be consistent with the institution's regular practices. The budget explanation should define concisely the role of each position in the overall project.

Equipment: DOE defines equipment as "an item of tangible personal property that has a useful life of more than two years and an acquisition cost of $25,000 or more." Special purpose equipment means equipment which is used only for research, scientific, or other technical activities. Items of needed equipment should be individually listed by description and estimated cost, including tax, and adequately justified. Allowable items ordinarily will be limited to scientific equipment that is not already available for the conduct of the work. General-purpose office equipment normally will not be considered eligible for support.

Domestic Travel The type and extent of travel and its relation to the research should be specified. Funds may be requested for attendance at meetings and conferences, travel associated with the proposed work, and subsistence. In order to qualify for support, attendance at meetings or conferences must enhance the investigator's capability to perform the research, plan extensions of it, or disseminate its results. Consultant's travel costs also may be requested. (Funds should be included for participation in an annual BME workshop for the lead investigator from each institution involved in the project.)

Foreign Travel Foreign travel is any travel outside Canada and the United States and its territories and possessions. Foreign travel may be approved only if it is directly related to project objectives.

Other Direct Costs The budget should itemize other anticipated direct costs not included under the headings above, including materials and supplies, publication costs, computer services, and consultant services (which are discussed below). Other examples are: aircraft rental, space rental at research establishments away from the institution, minor building alterations, service charges, and fabrication of equipment or systems not available off-the-shelf. Reference books and periodicals may be charged to the project only if they are specifically related to the research.

• Materials and Supplies: The budget should indicate in general terms the type of required expendable materials and supplies with their estimated costs. The breakdown should be more detailed when the cost is substantial.

• Publication Costs/Page Charges: The budget may request funds for the costs of preparing and publishing the results of research, including costs of reports, reprints page charges, or other journal costs (except costs for prior or early publication), and necessary illustrations.

• Consultant Services: Anticipated consultant services should be justified and information furnished on each individual's expertise, primary institutional affiliation, daily compensation rate, and number of days expected service. Consultant's travel costs should be listed separately under travel in the budget.

• Computer Services: The cost of computer services, including computer-based retrieval of scientific and technical information, may be requested. A justification based on the established computer service rates should be included.

• Subcontracts: Subcontracts should be listed so that they can be properly evaluated. There should be an anticipated cost and an explanation of that cost for each subcontract. The total amount of each subcontract should also appear as a budget item. (The budget for collaborating institutions should be submitted separately and not included in this item.)
• Indirect Costs: Explain the basis for each overhead and indirect cost. Include the current rates.

Other support is defined as all financial resources, whether Federal, non-Federal, commercial, or institutional, available in direct support of an individual's research endeavors. Information on active and pending other support is required for all senior personnel, including investigators at collaborating institutions to be funded by a subcontract. For each item of other support, give the institution or agency, inclusive dates of the project or proposed project, annual funding, and level of effort devoted to the project.

12. Abstract

Provide an abstract of no more than 400 words. Give the broad, long-term objectives and what the specific research proposed is intended to accomplish. The abstract must clearly discuss; (1) how the proposed research addresses the scientific/technical area specifically described in this announcement, (2) the collaborative nature of the project, and (3) the medical impact of the proposed research.

The narrative comprises the research plan for the project and is limited to 40 pages. It must contain the following subsections:

Proposal Summary: The Lead National Laboratory must include a section which clearly describes: (1) the overall goals and scope of the project, (2) the role to be played by each institution, (3) the managerial arrangements for the project, (4) the overall coordination of the project, (5) a discussion of use of National Laboratory resources and expertise, and (6) a discussion of the impact the research will have on health care.

Background and Significance: Briefly sketch the background leading to the present proposal, critically evaluate existing knowledge, and specifically identify the gaps which the project is intended to fill. State concisely the importance of the research described in the proposal. Explain the relevance of the project to the research needs identified by the Office of Science. Include references to relevant published literature, both to work of the investigators and to work done by other researchers.

Preliminary Studies: Use this section to provide an account of any preliminary studies that may be pertinent to the proposal. Include any other information that will help to establish the experience and competence of the investigators to pursue the proposed project. References to appropriate publications and manuscripts submitted or accepted for publication may be included.

Research Design and Methods: Describe the research design and the procedures to be used to accomplish the specific aims of the project. Describe new techniques and methodologies and explain the advantages over existing techniques and methodologies. As part of this section, provide a tentative sequence or timetable for the project.

Consortium Arrangements: If any portion of the project described under "Research Design and Methods" is to be done as a consortium with another institution, provide information on the institution and why it is to do the specific component of the project. Further information on any such arrangements is to be given in the sections "Budget and Budget Explanation," "Biographical Sketches," and "Description of Facilities and Resources".

List all references cited in the narrative. Limit citations to current literature relevant to the proposed research. Information about each reference should be sufficient for it to be located by a reviewer of the proposal.

15. Biographical Sketches

This information is required for senior personnel at the laboratory submitting the proposal and at all collaborating institutions. The biographical sketch is limited to a maximum of two pages for each investigator.

Describe briefly the facilities to be used for the conduct of the proposed research. Indicate the performance sites and describe pertinent capabilities, including support facilities (such as machine shops) that will be used during the project. List the most important equipment items already available for the project and their pertinent capabilities. Include this information for each collaborating institution, if any.

Include collated sets of all appendix materials with each copy of the proposal. Do not use the appendix to circumvent the page limitations of the proposal. Information should be included that may not be easily accessible to a reviewer. Reviewers are not required to consider information in the Appendix, only information in the body of the proposal. (Please Note: Reviewers may not have time to read the appendix materials with the same care as they would read the main proposal). The appendix may contain the following items: up to five publications, manuscripts (accepted for publication), abstracts, patents, or other printed materials directly relevant to this project, but not generally available to the scientific community; and letters from investigators at other institutions stating their agreement to participate in the project (do not include letters of endorsement of the project).

DOE policy requires that potential proposers adhere to 10 CFR Part 745 "Protection of Human Subjects,” or such later revision of those guidelines as may be published in the Federal Register

Any recipient of an award from SC performing research involving recombinant DNA molecules and/or organisms and viruses containing recombinant DNA molecules shall comply with the National Institutes of Health (NIH) "Guidelines for Research Involving Recombinant DNA Molecules," which is available via the world wide web at: http://www.niehs.nih.gov/odhsb/biosafe/nih/rdna-apr98.pdf, (59 FR 34496, July 5, 1994,) or such later revision of those guidelines as may be published in the Federal Register.