JONES RN, BIEDENBACH DJ; THE QUALITY CONTROL STUDY GROUP; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. D-169.

The JONES Group, North Liberty, IA

Background: BMS284756 (BMSQ) is a novel des-fluoro(6)-quinolone with antimicrobial activity similar to recently developed fluoroquinolones. The purpose of this investigation was to determine the appropriate DD and MIC quality control (QC) ranges for BMSQ against commonly used ATCC QC strains. Methods: BMSQ 5-mg disk content was tested against E. coli (EC) ATCC 25922, P. aeruginosa (PA) ATCC 27853, H. influenzae (HI) ATCC 49247, S. pneumoniae (SP) ATCC 49619 and S. aureus (SA) ATCC 25923. MIC QC was determined for all the above except SA 25923. In addition, E. faecalis (EF) ATCC 29212 and SA ATCC 29213 were evaluated by the broth microdilution method. The study design followed NCCLS M23 guideline and utilized NCCLS methods and appropriate media (HTM, Mueller-Hinton +/- LHB). Seven laboratories tested 2 disk lots on 3 agar media or 3 or 4 broth lots over a 10 day period generating 420 total disk values and 210 or 280 MIC values per organism. Internal QC using levofloxacin (LEVO) as the control agent and daily colony counts were performed. Results: Modal MIC values were within 2 log[2] dilutions among centers for all tested strains and the range spanned

Publication Types:

• Meeting Abstracts

Keywords:

• Fluoroquinolones
• Haemophilus influenzae
• Laboratories
• Microbial Sensitivity Tests
• Ofloxacin
• Quality Control
• Research Design
• garenoxacin
• methods

Other ID:

• GWAIDS0029277

UI: 102268909

From Meeting Abstracts